Gene Information gene info

GENE:KLHL3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KLHL3
FullNmae kelch like family member 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6354
EnsembleID ENSG00000146021
Uniprot Q9UH77

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KLHL3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KLHL3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
KLHL3 GO:0003779,GO:0005198,GO:0005515,GO:0005829,GO:0005829,GO:0005829,GO:0005856,GO:0006511,GO:0006511,GO:0010467,GO:0016567,GO:0016567,GO:0031463,GO:0031463,GO:0043161,GO:0050801,GO:0050801,GO:0055075,GO:0061912,GO:0070294,GO:0070294,GO:0070294,GO:0070936,GO:0070936,GO:0072156,GO:0097602,GO:1990756

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KLHL3 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 KLHL3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 KLHL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000013E79D KLHL3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F KLHL3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 KLHL3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 KLHL3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA KLHL3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 KLHL3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 KLHL3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 KLHL3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000035CC3E KLHL3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000A057E KLHL3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000005E58C KLHL3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001CE046 KLHL3 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000334286 KLHL3 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA KLHL3 22135298 phosphorylation N/A PhosphoSite
PRKCA KLHL3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
MORF4L2 KLHL3 25348397 N/A physical interaction ComPPI
CFAP206 KLHL3 25348397 N/A physical interaction ComPPI
KEAP1 KLHL3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLDN8 KLHL3 25348397 N/A physical interaction ComPPI
OPRD1 KLHL3 11259487 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KLHL3 SYT2 10734137 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KLHL3 SYNCRIP 10734137 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KLHL3 GNAI1 11259487 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KLHL3 GNAO1 11259487 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KLHL3 ELAVL1 25348397 N/A physical interaction ComPPI
KLHL3 SLC12A3 25348397 N/A physical interaction ComPPI
KLHL3 WNK1 25348397 N/A physical interaction ComPPI
KLHL3 WNK2 25348397 N/A physical interaction ComPPI
KLHL3 WNK3 25348397 N/A physical interaction ComPPI
KLHL3 CUL3 23665031 24234451 25348397 physical association pull down,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KLHL3 RBX1 25348397 N/A physical interaction ComPPI
KLHL3 WNK4 23453970 23576762 23665031 23838290 23962426 24234451 24641320 25313067 25348397 26286618 26349538 26435498 27898060 physical association pull down,physical interaction ComPPI,IntAct,OmniPath
KLHL3 KLHL12 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KLHL3 PRKACA 25348397 N/A physical interaction ComPPI
KLHL3 AKT1 25348397 N/A physical interaction ComPPI
KLHL3 SQSTM1 25348397 N/A physical interaction ComPPI
KLHL3 KLHL2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

Visualization