GENE:KLHL3
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | KLHL3 |
FullNmae | kelch like family member 3 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:6354 |
EnsembleID | ENSG00000146021 |
Uniprot | Q9UH77 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
KLHL3 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
KLHL3 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
KLHL3 | GO:0003779,GO:0005198,GO:0005515,GO:0005829,GO:0005829,GO:0005829,GO:0005856,GO:0006511,GO:0006511,GO:0010467,GO:0016567,GO:0016567,GO:0031463,GO:0031463,GO:0043161,GO:0050801,GO:0050801,GO:0055075,GO:0061912,GO:0070294,GO:0070294,GO:0070294,GO:0070936,GO:0070936,GO:0072156,GO:0097602,GO:1990756 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
YBX1 | KLHL3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
SMARCA4 | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXP1 | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
GATA2 | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | KLHL3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS000013E79D | KLHL3 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000021202F | KLHL3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000085F64 | KLHL3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000076B539 | KLHL3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000C48FA | KLHL3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075AAA0 | KLHL3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000006FDD4 | KLHL3 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000021D7C8 | KLHL3 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS000035CC3E | KLHL3 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS00000A057E | KLHL3 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS000005E58C | KLHL3 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS00001CE046 | KLHL3 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
URS0000334286 | KLHL3 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
MORF4L2 | KLHL3 | 25348397 | N/A | physical interaction | ComPPI |
CFAP206 | KLHL3 | 25348397 | N/A | physical interaction | ComPPI |
KEAP1 | KLHL3 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
CLDN8 | KLHL3 | 25348397 | N/A | physical interaction | ComPPI |
OPRD1 | KLHL3 | 11259487 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
KLHL3 | SYT2 | 10734137 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
KLHL3 | SYNCRIP | 10734137 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
KLHL3 | GNAI1 | 11259487 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
KLHL3 | GNAO1 | 11259487 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
KLHL3 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | SLC12A3 | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | WNK1 | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | WNK2 | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | WNK3 | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | CUL3 | 23665031 24234451 25348397 | physical association | pull down,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
KLHL3 | RBX1 | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | WNK4 | 23453970 23576762 23665031 23838290 23962426 24234451 24641320 25313067 25348397 26286618 26349538 26435498 27898060 | physical association | pull down,physical interaction | ComPPI,IntAct,OmniPath |
KLHL3 | KLHL12 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
KLHL3 | PRKACA | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | AKT1 | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | SQSTM1 | 25348397 | N/A | physical interaction | ComPPI |
KLHL3 | KLHL2 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |