GENE：LACRT
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LACRT |
| FullNmae | lacritin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16430 |
| EnsembleID | ENSG00000135413 |
| Uniprot | Q9GZZ8 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LACRT | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LACRT | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LACRT | GO:0005515,GO:0005518,GO:0005576,GO:0005576,GO:0005615,GO:0006473,GO:0008083,GO:0008284,GO:0008284,GO:0010669,GO:0016239,GO:0019722,GO:0019722,GO:0030141,GO:0030141,GO:0031665,GO:0033173,GO:0034067,GO:0042742,GO:0043066,GO:0043237,GO:0050679,GO:0050731,GO:0050850,GO:0051047,GO:0051047,GO:0051281,GO:0060054,GO:0070075,GO:0070075,GO:0070886 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | LACRT | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | LACRT | 20953172 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | LACRT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | LACRT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LACRT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EHMT2 | LACRT | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| DUSP12 | LACRT | 25348397 | N/A | physical interaction | ComPPI |
| PPP1R3C | LACRT | 25348397 | N/A | physical interaction | ComPPI |
| SMAD3 | LACRT | 25348397 | N/A | physical interaction | ComPPI |
| TGM2 | LACRT | 25348397 | N/A | physical interaction | ComPPI |
| ACOX1 | LACRT | 25348397 | N/A | physical interaction | ComPPI |
| VTN | LACRT | 11419941 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| POLL | LACRT | 25348397 | N/A | physical interaction | ComPPI |
| SDC1 | LACRT | 14525934 16982797 23504321 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| WWOX | LACRT | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | NID1 | 11419941 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| LACRT | FN1 | 11419941 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| LACRT | APP | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | HECW2 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | KCNIP4 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | CCDC148 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | RSPO1 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | C22ORF31 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | MRPL12 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | SLC25A10 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | PRAP1 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | NEUROD1 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | FN3KRP | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | ALDH3B1 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | DUSP13 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | DUSP13 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | DDX31 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | PLXNA2 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | PCYOX1L | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | SNX27 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | HBM | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | KATNA1 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | ARSK | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | SLC2A6 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | KIAA0319L | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | THUMPD2 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | TTLL9 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | NDST2 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | EMC4 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | SELENON | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | CASP5 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | PCK2 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | RNF114 | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | RNGTT | 25348397 | N/A | physical interaction | ComPPI |
| LACRT | MAP1LC3C | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| LACRT | AEBP2 | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| LACRT | KSR1 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |