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GENE：MAPK15

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAPK15
FullNmae mitogen-activated protein kinase 15
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24667
EnsembleID ENSG00000181085
Uniprot Q8TD08

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAPK15 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAPK15 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MAPK15 GO:0000165,GO:0003400,GO:0003682,GO:0004672,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005776,GO:0005794,GO:0005814,GO:0005911,GO:0005923,GO:0006974,GO:0007029,GO:0008284,GO:0008284,GO:0010506,GO:0016301,GO:0017124,GO:0030336,GO:0031410,GO:0032212,GO:0032212,GO:0035556,GO:0036064,GO:0046777,GO:0051973,GO:0051973,GO:0072687,GO:0090494,GO:0106310,GO:1902017,GO:1902017,GO:1904355,GO:1904355,GO:1904491,GO:1905188,GO:1905832

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAPK15 hsa:225689 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTCF MAPK15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAPK15 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAPK15 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
MAPK15 JUN 22135298 phosphorylation N/A PhosphoSite
MAPK15 TGFB1I1 25361965 interaction type N/A PTMCode2
TGFB1I1 MAPK15 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PCNA MAPK15 25348397 N/A physical interaction ComPPI
MAP1LC3B MAPK15 25348397 N/A physical interaction ComPPI
HSP90AB1 MAPK15 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SRC MAPK15 11875070 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HSP90AA1 MAPK15 25348397 N/A physical interaction ComPPI
ESYT2 MAPK15 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RBM14 MAPK15 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIGR MAPK15 25348397 N/A physical interaction ComPPI
LTF MAPK15 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CSK MAPK15 11875070 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CDK2 MAPK15 23455922 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
EGFR MAPK15 25348397 N/A physical interaction ComPPI
TGFB1I1 MAPK15 14525934 16624805 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MBP MAPK15 11875070 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK12 MAPK15 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GABARAP MAPK15 25348397 N/A physical interaction ComPPI
MAPK15 NR3C1 14525934 16624805 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MAPK15 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAPK15 GABARAPL1 25348397 N/A physical interaction ComPPI
MAPK15 WDR81 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK15 CACNA1H 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK15 B2M 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK15 NAMPT 25348397 N/A physical interaction ComPPI
MAPK15 CCT2 25348397 N/A physical interaction ComPPI
MAPK15 CCT3 25348397 N/A physical interaction ComPPI
MAPK15 CCT6B 25348397 N/A physical interaction ComPPI
CLIC3 MAPK15 14525934 25348397 9880541 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK15 MAPK15 11875070 14525934 N/A experimental interaction detection HPRD
PTPN1 MAPK15 16336213 27898060 inhibition N/A OmniPath
PPP2CA MAPK15 16336213 27898060 inhibition N/A OmniPath
MAPK15 JUN 11278277 11401472 11432833 11739718 12040039 12169099 12221076 12818176 12853483 14617628 1496019 15378002 16023596 16819515 17215518 17920329 18443042 18572021 18650425 1922387 20028971 21177766 21212517 21697492 23720779 25561726 27898060 7744008 8072547 8137421 8224842 9662434 stimulant N/A OmniPath
CSK MAPK15 11875070 27898060 N/A N/A OmniPath

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