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GENE：MTMR4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MTMR4
FullNmae myotubularin related protein 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7452
EnsembleID ENSG00000108389
Uniprot Q9NYA4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MTMR4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MTMR4 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MTMR4 GO:0004438,GO:0004438,GO:0004722,GO:0004725,GO:0005515,GO:0005615,GO:0005737,GO:0005768,GO:0005829,GO:0006470,GO:0006661,GO:0010506,GO:0016020,GO:0019903,GO:0019903,GO:0030512,GO:0031901,GO:0046856,GO:0046872,GO:0052629,GO:0052629,GO:0060304

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MTMR4 hsa:9110 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
MTMR4 hsa:9110 path:hsa01100 Metabolic pathways - Homo sapiens (human)
MTMR4 hsa:9110 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
MTMR4 hsa:9110 path:hsa04140 Autophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MTMR4 SMAD2 20704570 23331499 stimulation N/A SignaLink,SignaLink
MTMR4 SMAD3 20704570 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MTMR4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MTMR4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MTMR4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MTMR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MTMR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MTMR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MTMR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MTMR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MTMR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MTMR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MTMR4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB MTMR4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000AA464 MTMR4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000204177 MTMR4 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000079D48 MTMR4 21572407 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C1E1 MTMR4 21572407 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004A9320 MTMR4 21572407 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000040EE1D MTMR4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C MTMR4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 MTMR4 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ZNF408 MTMR4 25348397 N/A physical interaction ComPPI
RAB8A MTMR4 25348397 N/A physical interaction ComPPI
ATR MTMR4 25348397 N/A physical interaction ComPPI
SMAD2 MTMR4 20061380 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SMAD3 MTMR4 20061380 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
RHPN1 MTMR4 25348397 N/A physical interaction ComPPI
YWHAB MTMR4 25348397 N/A physical interaction ComPPI
YWHAZ MTMR4 25348397 N/A physical interaction ComPPI
CSNK1E MTMR4 25348397 N/A physical interaction ComPPI
POLDIP2 MTMR4 25348397 N/A physical interaction ComPPI
DUSP7 MTMR4 25348397 N/A physical interaction ComPPI
AP2A2 MTMR4 25348397 N/A physical interaction ComPPI
GOLGA5 MTMR4 25348397 N/A physical interaction ComPPI
EXOC4 MTMR4 25348397 N/A physical interaction ComPPI
CEP55 MTMR4 25348397 N/A physical interaction ComPPI
RAB11A MTMR4 25348397 N/A physical interaction ComPPI
YWHAH MTMR4 25348397 N/A physical interaction ComPPI
ALOX5 MTMR4 25348397 N/A physical interaction ComPPI
PRKCI MTMR4 25348397 N/A physical interaction ComPPI
AURKA MTMR4 25348397 N/A physical interaction ComPPI
NEDD4 MTMR4 19125695 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HIPK3 MTMR4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
AP2M1 MTMR4 25348397 N/A physical interaction ComPPI
TRIM25 MTMR4 25348397 N/A physical interaction ComPPI
ENSA MTMR4 25348397 N/A physical interaction ComPPI
ELAVL1 MTMR4 25348397 N/A physical interaction ComPPI
RB1CC1 MTMR4 25348397 N/A physical interaction ComPPI
MED18 MTMR4 25348397 N/A physical interaction ComPPI
SMG7 MTMR4 25348397 N/A physical interaction ComPPI
NTAQ1 MTMR4 25348397 N/A physical interaction ComPPI
ZNF414 MTMR4 25348397 N/A physical interaction ComPPI
DNAJC10 MTMR4 25348397 N/A physical interaction ComPPI
ZNF263 MTMR4 25348397 N/A physical interaction ComPPI
MRPL38 MTMR4 25348397 N/A physical interaction ComPPI
KSR1 MTMR4 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
HOOK3 MTMR4 25348397 N/A physical interaction ComPPI
MTMR4 MTMR3 25348397 N/A physical interaction ComPPI
MTMR4 TMEM160 25348397 N/A physical interaction ComPPI
MTMR4 SCO2 25348397 N/A physical interaction ComPPI
MTMR4 ACAD11 25348397 N/A physical interaction ComPPI
MTMR4 ZNF669 25348397 N/A physical interaction ComPPI
MTMR4 CDO1 25348397 N/A physical interaction ComPPI
MTMR4 ZNF684 25348397 N/A physical interaction ComPPI
MTMR4 ZSCAN31 25348397 N/A physical interaction ComPPI
MTMR4 ATP6V1G3 25348397 N/A physical interaction ComPPI
MTMR4 TBRG4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MTMR4 SMAD2 20061380 27898060 inhibition N/A OmniPath
MTMR4 SMAD3 20061380 27898060 inhibition N/A OmniPath

Visualization










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