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GENE：NOD2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NOD2
FullNmae nucleotide binding oligomerization domain containing 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5331
EnsembleID ENSG00000167207
Uniprot Q9HC29

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NOD2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NOD2 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
NOD2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NOD2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NOD2 GO:0001659,GO:0002221,GO:0002227,GO:0002250,GO:0002606,GO:0002710,GO:0002720,GO:0002732,GO:0002815,GO:0002830,GO:0002862,GO:0002925,GO:0003779,GO:0005515,GO:0005524,GO:0005737,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0006909,GO:0006952,GO:0006965,GO:0007249,GO:0007254,GO:0007584,GO:0009595,GO:0009986,GO:0010936,GO:0016045,GO:0016323,GO:0019897,GO:0019899,GO:0019901,GO:0030277,GO:0030544,GO:0031982,GO:0032098,GO:0032495,GO:0032495,GO:0032495,GO:0032498,GO:0032500,GO:0032689,GO:0032695,GO:0032701,GO:0032703,GO:0032720,GO:0032731,GO:0032731,GO:0032733,GO:0032735,GO:0032740,GO:0032755,GO:0032757,GO:0032760,GO:0032760,GO:0032874,GO:0032991,GO:0034134,GO:0034136,GO:0034976,GO:0035556,GO:0035556,GO:0036335,GO:0038061,GO:0038187,GO:0042742,GO:0042742,GO:0042834,GO:0043123,GO:0043123,GO:0043123,GO:0043130,GO:0043330,GO:0043406,GO:0043531,GO:0043552,GO:0044877,GO:0045087,GO:0045087,GO:0045335,GO:0045747,GO:0045944,GO:0046330,GO:0046645,GO:0048874,GO:0050679,GO:0050700,GO:0050727,GO:0050731,GO:0050766,GO:0050871,GO:0051092,GO:0051092,GO:0051353,GO:0051649,GO:0051770,GO:0051879,GO:0060585,GO:0060907,GO:0070371,GO:0070374,GO:0070431,GO:0071222,GO:0071224,GO:0071225,GO:0071225,GO:0071407,GO:0071639,GO:0090022,GO:0098792,GO:1900017,GO:1901224,GO:1901526,GO:1902523,GO:1904417,GO:2000110,GO:2000363

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NOD2 hsa:64127 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
NOD2 hsa:64127 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
NOD2 hsa:64127 path:hsa05152 Tuberculosis - Homo sapiens (human)
NOD2 hsa:64127 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOD2 MAP3K7 15075345 17348859 17965022 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
ACAP1 NOD2 17005562 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
COPS6 NOD2 17337451 23180781 physical association anti tag coimmunoprecipitation InnateDB
ERBIN NOD2 16203728 16714539 18684957 19266573 19853919 23180781 physical association anti tag coimmunoprecipitation,two hybrid,mass spectrometry studies of complexes,tandem affinity purification InnateDB
RIPK2 NOD2 16492792 16552041 16714539 17054981 19266573 19337385 19464198 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD2 CARD9 17187069 23180781 24960071 physical association anti tag coimmunoprecipitation InnateDB
RAC1 NOD2 17356065 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 MAP3K14 16552041 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 NOD2 16492792 19337385 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD2 CASP1 15107016 18511561 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP1 NOD2 18511561 19337385 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD2 CASP4 18511561 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 SUGT1 17420470 17435760 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 NLRC4 15107016 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 RIPK2 19667203 23180781 24790089 physical association anti tag coimmunoprecipitation InnateDB
NOD2 XIAP 19667203 23180781 physical association anti tag coimmunoprecipitation InnateDB
DUOX2 NOD2 19759286 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 AAMP 19535145 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 NLRP3 19337385 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD2 ATG16L1 19898471 23180781 physical association anti tag coimmunoprecipitation InnateDB
VDR NOD2 19948723 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 NDUFA13 15753091 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD2 OAS2 19853919 23180781 physical association anti tag coimmunoprecipitation,tandem affinity purification InnateDB
NOD2 HNRNPA1 19349988 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 MAPK14 19349988 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 CARD8 20385562 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 RELA 20436512 23180781 physical association anti tag coimmunoprecipitation InnateDB
BID NOD2 21552281 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 DDX58 21690088 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
NOD2 RAC1 18684957 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 ARHGEF7 18684957 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 ERBIN 18684957 23180781 physical association anti tag coimmunoprecipitation InnateDB
SQSTM1 NOD2 23180781 23437331 physical association anti tag coimmunoprecipitation InnateDB
NOD2 TRIM27 22829933 23180781 physical association anti tag coimmunoprecipitation InnateDB
CAD NOD2 22387394 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOD2 HSPA1A 23180781 24790089 physical association anti tag coimmunoprecipitation,fluorescence microscopy InnateDB

Source Target Pmid Interactiontype Methods Database
NOD2 RIPK2 20005715 interaction type N/A PSP
NOD2 CASP1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR NOD2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 NOD2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NOD2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NOD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 NOD2 12671897 trascriptional regulation,stimulation inferred by curator TFlink
NR1I2 NOD2 14688115 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 NOD2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 NOD2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00003380CC NOD2 23872065 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016D2D4 NOD2 25281418 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003CF1AD NOD2 25416803 26752466 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
VIM NOD2 21699783 22684479 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
TNFAIP3 NOD2 25348397 N/A physical interaction ComPPI
TRAF6 NOD2 25348397 N/A physical interaction ComPPI
XIAP NOD2 19667203 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
OLFM4 NOD2 20534456 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FIS1 NOD2 21699783 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
ERBIN NOD2 16203728 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,in vivo,confocal microscopy ComPPI,IntAct
TLE1 NOD2 21699783 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
UBC NOD2 25348397 N/A physical interaction ComPPI
CASP1 NOD2 18511561 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
SQSTM1 NOD2 25348397 N/A physical interaction ComPPI
PPP2R5E NOD2 21699783 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
COPS6 NOD2 25348397 N/A physical interaction ComPPI
RIPK1 NOD2 25348397 N/A physical interaction ComPPI
RIPK2 NOD2 11087742 14525934 21931826 22829933 24234451 25348397 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TRAF4 NOD2 25348397 N/A physical interaction ComPPI
MAP3K7 NOD2 25348397 N/A physical interaction ComPPI
BIRC2 NOD2 25348397 N/A physical interaction ComPPI
BIRC3 NOD2 25348397 N/A physical interaction ComPPI
CASP4 NOD2 18511561 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOD1 NOD2 25348397 N/A physical interaction ComPPI
NLRP1 NOD2 18511561 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM27 NOD2 22829933 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
NOD2 NLRC4 11472070 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NOD2 NAT16 25348397 N/A physical interaction ComPPI
NOD2 IKBKG 25348397 N/A physical interaction ComPPI
NOD2 RNF31 25348397 N/A physical interaction ComPPI
NOD2 RBCK1 25348397 N/A physical interaction ComPPI
NOD2 SHARPIN 25348397 N/A physical interaction ComPPI
NOD2 GALNT2 21699783 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
NOD2 KAT5 21699783 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
NOD2 CASP12 25348397 N/A physical interaction ComPPI
NOD2 SUGT1 17420470 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOD2 ATG16L1 23376921 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
NOD2 IRGM 25348397 N/A physical interaction ComPPI
NOD2 CYLD 25348397 N/A physical interaction ComPPI
NOD2 SLC15A3 24234451 24695226 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOD2 SLC15A4 24234451 24695226 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOD2 ANKRD17 23711367 24234451 25348397 27898060 colocalization fluorescence microscopy ComPPI,IntAct,OmniPath
NOD2 TRIM8 22829933 24234451 25348397 physical association two hybrid ComPPI,IntAct
NOD2 TRIM50 22829933 24234451 25348397 physical association two hybrid ComPPI,IntAct
NOD2 NDUFA13 15753091 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,confocal microscopy ComPPI,IntAct
NOD2 TRIM27 22829933 27898060 N/A N/A OmniPath
CASP1 NOD2 15107016 18511561 27898060 N/A N/A OmniPath
NOD2 CASP1 15107016 18511561 27898060 N/A N/A OmniPath
MAP3K7 NOD2 15075345 17348859 17965022 27898060 N/A N/A OmniPath
NOD2 MAP3K7 10702308 15075345 17079228 17348859 17947236 17965022 27898060 N/A N/A OmniPath
CASP4 NOD2 18511561 27898060 N/A N/A OmniPath
ABL2 NOD2 21552281 27898060 N/A N/A OmniPath
NLRP1 NOD2 18511561 19337385 27898060 N/A N/A OmniPath
NOD2 NLRP1 18511561 19337385 27898060 stimulant N/A OmniPath
NOD2 RIPK2 11087742 11894098 15107016 15620648 16203728 16492792 16552041 16714539 17054981 17355968 18775659 19266573 19337385 19464198 19592251 19667203 21097508 21123652 22470564 22607974 22665475 22829933 24790089 26670046 27898060 inhibition,stimulant N/A OmniPath
HSPA1A NOD2 24790089 27898060 stimulant N/A OmniPath
NOD2 NLRP3 19337385 27898060 N/A N/A OmniPath
NOD2 MAP3K14 16552041 27898060 stimulant N/A OmniPath
XIAP NOD2 19667203 22607974 27898060 N/A N/A OmniPath
NOD2 RAC1 17356065 18684957 27898060 N/A N/A OmniPath
NOD2 CARD8 20385562 27898060 N/A N/A OmniPath
NOD2 COPS6 17337451 27898060 N/A N/A OmniPath
NOD2 ATG16L1 19898471 23376921 27898060 stimulant N/A OmniPath
NOD2 MAPK14 14560001 15692051 17187069 17947236 17965022 19349988 27898060 stimulant N/A OmniPath
HSP90AA1 NOD2 23019338 27898060 stimulant N/A OmniPath
NOD2 NFKBIA 10195894 11087742 12514169 16493424 17965022 27898060 7739562 7796813 7862124 7878466 8657102 N/A N/A OmniPath
NOD2 MAPK1 14560001 15692050 15692051 27898060 stimulant N/A OmniPath
HSPA1B NOD2 24790089 27898060 stimulant N/A OmniPath
DDX58 NOD2 21690088 27898060 N/A N/A OmniPath
NLRC4 NOD2 11472070 15107016 27898060 inhibition N/A OmniPath
SQSTM1 NOD2 23437331 27898060 N/A N/A OmniPath
HSP90AB1 NOD2 23019338 27898060 stimulant N/A OmniPath
NOD2 MAPK8 15692051 17187069 17947236 17965022 27898060 stimulant N/A OmniPath
CAD NOD2 22387394 27898060 N/A N/A OmniPath
NOD2 IKBKB 10094049 10195894 10837071 15327770 15620648 15691841 16186825 16260493 16493424 17965022 27898060 N/A N/A OmniPath
NOD2 OAS2 19853919 27898060 N/A N/A OmniPath
NOD2 ARHGEF7 18684957 27898060 N/A N/A OmniPath
DUOX2 NOD2 19759286 27898060 N/A N/A OmniPath
NOD2 NOD1 15107016 27898060 inhibition N/A OmniPath
NOD2 HNRNPA1 19349988 27898060 N/A N/A OmniPath
NOD2 CARD9 17187069 24960071 27898060 N/A N/A OmniPath
NOD2 NDUFA13 15753091 27898060 N/A N/A OmniPath
NOD2 SUGT1 17420470 17435760 27898060 N/A N/A OmniPath
SUGT1 NOD2 17420470 17435760 27898060 N/A N/A OmniPath
ERBIN NOD2 16203728 16714530 16714539 18684957 19266573 19853919 27898060 inhibition N/A OmniPath
NOD2 ERBIN 16203728 16714530 16714539 18684957 19266573 19853919 27898060 N/A N/A OmniPath
NOD2 ACAP1 17005562 27898060 N/A N/A OmniPath
NOD2 AAMP 19535145 27898060 N/A N/A OmniPath
NOD2 DEFA5 15479689 27898060 stimulant N/A OmniPath
NOD2 DEFB104A 16319062 27898060 stimulant N/A OmniPath

Visualization










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