GENE：NUPR1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NUPR1 |
| FullNmae | nuclear protein 1, transcriptional regulator |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29990 |
| EnsembleID | ENSG00000176046 |
| Uniprot | O60356 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NUPR1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NUPR1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NUPR1 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| NUPR1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NUPR1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NUPR1 | GO:0002526,GO:0003677,GO:0003677,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0008285,GO:0008584,GO:0009636,GO:0010506,GO:0010507,GO:0010507,GO:0010667,GO:0010667,GO:0010698,GO:0031401,GO:0032993,GO:0035914,GO:0042771,GO:0043066,GO:0043433,GO:0043433,GO:0043525,GO:0044346,GO:0045171,GO:0045786,GO:0045786,GO:0045787,GO:0045820,GO:0045893,GO:0048144,GO:0048147,GO:0048471,GO:0050680,GO:0062099,GO:0065003,GO:0150078,GO:1901800,GO:1902902,GO:1903862,GO:1904036,GO:1904691,GO:1905897,GO:1905897,GO:2000194,GO:2000271,GO:2001244,GO:2001244 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NUPR1 | hsa:26471 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | NUPR1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | NUPR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NUPR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NUPR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NUPR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | NUPR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | NUPR1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF4 | NUPR1 | 19946894 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NUPR1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPRE1 | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SET | NUPR1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| RAN | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| MYOD1 | NUPR1 | 25348397 | N/A | physical interaction | ComPPI |
| EP300 | NUPR1 | 11940591 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| COPS5 | NUPR1 | 16300740 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| NONO | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PAXIP1 | NUPR1 | 11940591 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| SEMG1 | NUPR1 | 25348397 | N/A | physical interaction | ComPPI |
| SEMG2 | NUPR1 | 25348397 | N/A | physical interaction | ComPPI |
| RANBP1 | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| MORF4L1 | NUPR1 | 25348397 | N/A | physical interaction | ComPPI |
| SYNCRIP | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PSMD4 | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| RPL41 | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| FUS | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| STX18 | NUPR1 | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| NUPR1 | PTMA | 16478804 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,circular dichroism,classical fluorescence spectroscopy,two hybrid,nuclear magnetic resonance,physical interaction | ComPPI,IntAct,OmniPath |
| NUPR1 | NACA | 25348397 | N/A | physical interaction | ComPPI |
| NUPR1 | SEC11A | 16478804 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |