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GENE：ORMDL3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ORMDL3
FullNmae ORMDL sphingolipid biosynthesis regulator 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16038
EnsembleID ENSG00000172057
Uniprot Q8N138

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ORMDL3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ORMDL3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ORMDL3 GO:0002903,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0006672,GO:0006672,GO:0006686,GO:0006940,GO:0010508,GO:0010508,GO:0030148,GO:0030667,GO:0035339,GO:0035339,GO:0035579,GO:0042552,GO:0061744,GO:0090156,GO:1900060,GO:1900182

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SULT1E1 ORMDL3 22546552 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 ORMDL3 22546552 23180781 physical association anti tag coimmunoprecipitation InnateDB
ORMDL3 CREB1 22546552 23180781 physical association anti tag coimmunoprecipitation InnateDB
ORMDL3 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ORMDL3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ORMDL3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ORMDL3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ORMDL3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ORMDL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 ORMDL3 23461825 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000042E1F ORMDL3 22473208 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00000600E6 ORMDL3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 ORMDL3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 ORMDL3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 ORMDL3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 ORMDL3 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000BD6DC ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009EA8F ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000393C7 ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000021202F ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002D2333 ORMDL3 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CE046 ORMDL3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ORMDL3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ORMDL3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ORMDL3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 ORMDL3 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SPTLC1 ORMDL3 25361965 interaction type N/A PTMCode2
ORMDL3 SPTLC1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LMNA ORMDL3 25348397 N/A physical interaction ComPPI
SLC7A1 ORMDL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF5 ORMDL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SLC1A1 ORMDL3 25348397 N/A physical interaction ComPPI
PTPN11 ORMDL3 25348397 N/A physical interaction ComPPI
EEF1A1 ORMDL3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ROM1 ORMDL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EBP ORMDL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SYT2 ORMDL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ELAVL1 ORMDL3 25348397 N/A physical interaction ComPPI
SPRY4 ORMDL3 25348397 N/A physical interaction ComPPI
LNX1 ORMDL3 25348397 N/A physical interaction ComPPI
SPTLC1 ORMDL3 20182505 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COQ8A ORMDL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 EEF1A1P5 25348397 N/A physical interaction ComPPI
ORMDL3 APP 25348397 N/A physical interaction ComPPI
ORMDL3 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ORMDL3 SLC22A9 25348397 N/A physical interaction ComPPI
ORMDL3 SLC2A12 25348397 N/A physical interaction ComPPI
ORMDL3 REEP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 GET1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 LEPROTL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 RETREG3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 KCNK5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 GPR101 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 ARL13B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 CERS3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 GPR152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORMDL3 ELOVL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MTIF3 ORMDL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

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