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GENE：PIK3C2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIK3C2A
FullNmae phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8971
EnsembleID ENSG00000011405
Uniprot O00443

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIK3C2A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3C2A autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PIK3C2A GO:0005524,GO:0005654,GO:0005737,GO:0005737,GO:0005802,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005942,GO:0006661,GO:0006887,GO:0006897,GO:0007173,GO:0008286,GO:0010508,GO:0014829,GO:0016020,GO:0016303,GO:0016303,GO:0016303,GO:0016310,GO:0016477,GO:0030136,GO:0030276,GO:0031982,GO:0035005,GO:0035005,GO:0035005,GO:0035091,GO:0036092,GO:0043231,GO:0043491,GO:0046934,GO:0048008,GO:0048015,GO:0048268,GO:0061024,GO:0070062,GO:0090050

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIK3C2A hsa:5286 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
PIK3C2A hsa:5286 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PIK3C2A hsa:5286 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PIK3C2A hsa:5286 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PIK3C2A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PIK3C2A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PIK3C2A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PIK3C2A 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PIK3C2A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PIK3C2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 PIK3C2A 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000096022 PIK3C2A 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000009262D PIK3C2A 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS0000237CBD PIK3C2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC379 PIK3C2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000451A1 PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D12AC PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 PIK3C2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C4762 PIK3C2A 25416803 25760926 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 PIK3C2A 22135298 phosphorylation N/A PhosphoSite
PIK3C2A ERBB2 25361965 interaction type N/A PTMCode2
ERBB2 PIK3C2A 25361965 interaction type N/A PTMCode2
PIK3C2A EGFR 25361965 interaction type N/A PTMCode2
EGFR PIK3C2A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
AMOT PIK3C2A 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
QPRT PIK3C2A 25348397 N/A physical interaction ComPPI
PPP1CB PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERBB2 PIK3C2A 10805725 14525934 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CDC16 PIK3C2A 25348397 N/A physical interaction ComPPI
FLNA PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAB PIK3C2A 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 PIK3C2A 25348397 N/A physical interaction ComPPI
PICALM PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IQGAP1 PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PA2G4 PIK3C2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYO18A PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARRB1 PIK3C2A 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTC PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPLP0 PIK3C2A 25348397 N/A physical interaction ComPPI
ARRB2 PIK3C2A 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR PIK3C2A 10805725 14525934 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
FKBP4 PIK3C2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THBS3 PIK3C2A 25348397 N/A physical interaction ComPPI
OCRL PIK3C2A 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP1LC3A PIK3C2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYO6 PIK3C2A 25348397 N/A physical interaction ComPPI
PGK1 PIK3C2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM25 PIK3C2A 25348397 N/A physical interaction ComPPI
GAK PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLINT1 PIK3C2A 25348397 N/A physical interaction ComPPI
TRIM27 PIK3C2A 25348397 N/A physical interaction ComPPI
STAMBP PIK3C2A 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLH1 PIK3C2A 25348397 N/A physical interaction ComPPI
TOMM20 PIK3C2A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EIF3A PIK3C2A 25348397 N/A physical interaction ComPPI
SYNPO PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAMBPL1 PIK3C2A 25348397 N/A physical interaction ComPPI
FBXW11 PIK3C2A 25348397 N/A physical interaction ComPPI
ANLN PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG7 PIK3C2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYH9 PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PMS2 PIK3C2A 25348397 N/A physical interaction ComPPI
CLTA PIK3C2A 25348397 N/A physical interaction ComPPI
NINL PIK3C2A 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PMS1 PIK3C2A 25348397 N/A physical interaction ComPPI
LIMA1 PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TKT PIK3C2A 25348397 N/A physical interaction ComPPI
DBN1 PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAGED2 PIK3C2A 25348397 N/A physical interaction ComPPI
SEC16A PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C2A PMS2CL 25348397 N/A physical interaction ComPPI
PIK3C2A ANKFY1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C2A TARS1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C2A LGR4 25348397 N/A physical interaction ComPPI
PIK3C2A SLC25A41 25348397 N/A physical interaction ComPPI
PIK3C2A THBS4 25348397 N/A physical interaction ComPPI
PIK3C2A CCNJL 25348397 N/A physical interaction ComPPI
PIK3C2A RPLP0P6 25348397 N/A physical interaction ComPPI
PIK3C2A CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C2A GTSE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C2A MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C2A ARX 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3C2A FAM136A 25348397 N/A physical interaction ComPPI
PIK3C2A C6ORF141 25348397 N/A physical interaction ComPPI
PIK3C2A CRYL1 25348397 N/A physical interaction ComPPI
PIK3C2A NCAPH2 25348397 N/A physical interaction ComPPI
PIK3C2A PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
HAVCR2 PIK3C2A 25348397 N/A physical interaction ComPPI
PIK3C2A PIK3C2A 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
IGF1R PIK3C2A 27898060 7692086 stimulant N/A OmniPath
CDK1 PIK3C2A 12719431 27898060 inhibition N/A OmniPath

Visualization










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