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GENE：TXN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TXN
FullNmae thioredoxin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12435
EnsembleID ENSG00000136810
Uniprot P10599

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TXN necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TXN GO:0000122,GO:0003723,GO:0004791,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0009314,GO:0015035,GO:0032148,GO:0033138,GO:0042803,GO:0043388,GO:0045454,GO:0045454,GO:0046826,GO:0047134,GO:0051897,GO:0061692,GO:0070062,GO:0071731,GO:2000170

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TXN hsa:7295 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
TXN hsa:7295 path:hsa05012 Parkinson disease - Homo sapiens (human)
TXN hsa:7295 path:hsa05132 Salmonella infection - Homo sapiens (human)
TXN hsa:7295 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K5 TXN 11274345 12556535 12655147 18792398 20414655 26192618 association N/A ACSN
TXNRD1 TXN 26192618 interaction type N/A ACSN
NFE2L2 TXN 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19747488 23850759 26192618 interaction type N/A ACSN
RRM1 TXN 26192618 interaction type N/A ACSN
RRM2 TXN 26192618 interaction type N/A ACSN
TXN MAP3K5 12077134 19880523 23180781 physical association anti tag coimmunoprecipitation InnateDB
HNRNPD TXN 15257295 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL7R TXN 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
TXNIP TXN 20023662 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYD88 TXN 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB

Source Target Pmid Interactiontype Methods Database
TXN NR3C1 18988627 20005715 21071413 9915858 interaction type N/A PSP,SignaLink
TXN MAP3K5 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
MYC TXN 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 TXN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
NFE2L2 TXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 TXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HSF2 TXN 9374530 trascriptional regulation,stimulation inferred by curator TFlink
JUN TXN 12414792 trascriptional regulation,stimulation inferred by curator TFlink
PPARD TXN 18048767 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 TXN N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000FC8EB TXN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D TXN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 TXN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000215483 TXN 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000045B99E TXN 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 TXN 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCA TXN 22135298 phosphorylation N/A PhosphoSite
TXNIP TXN 25361965 interaction type N/A PTMCode2
TXN TXNIP 25361965 interaction type N/A PTMCode2
RRM1 TXN 25361965 interaction type N/A PTMCode2
TXN RRM1 25361965 interaction type N/A PTMCode2
TP53 TXN 25361965 interaction type N/A PTMCode2
TXN TP53 25361965 interaction type N/A PTMCode2
NR3C1 TXN 25361965 interaction type N/A PTMCode2
TXN NR3C1 25361965 interaction type N/A PTMCode2
GLRX TXN 25361965 interaction type N/A PTMCode2
TXN GLRX 25361965 interaction type N/A PTMCode2
APEX1 TXN 25361965 interaction type N/A PTMCode2
TXN APEX1 25361965 interaction type N/A PTMCode2
COL1A1 TXN 25361965 interaction type N/A PTMCode2
TXN COL1A1 25361965 interaction type N/A PTMCode2
NFKB1 TXN 25361965 interaction type N/A PTMCode2
TXN NFKB1 25361965 interaction type N/A PTMCode2
MSRA TXN 25361965 interaction type N/A PTMCode2
TXN MSRA 25361965 interaction type N/A PTMCode2
PRDX6 TXN 25361965 interaction type N/A PTMCode2
TXN PRDX6 25361965 interaction type N/A PTMCode2
MAP3K5 TXN 25361965 interaction type N/A PTMCode2
TXN MAP3K5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 TXN 25348397 N/A physical interaction ComPPI
TXN2 TXN 25348397 N/A physical interaction ComPPI
EIF1B TXN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IFIT3 TXN 21642987 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAX1BP3 TXN 25348397 N/A physical interaction ComPPI
ZNRD2 TXN 25348397 N/A physical interaction ComPPI
NPM1 TXN 25348397 N/A physical interaction ComPPI
VIM TXN 25348397 N/A physical interaction ComPPI
CDKN1A TXN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUP62 TXN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMD14 TXN 25348397 N/A physical interaction ComPPI
UBL4A TXN 25348397 N/A physical interaction ComPPI
TRAF6 TXN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GABARAPL2 TXN 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FKBP1A TXN 25348397 N/A physical interaction ComPPI
DCUN1D1 TXN 25348397 N/A physical interaction ComPPI
PTPN6 TXN 25348397 N/A physical interaction ComPPI
KEAP1 TXN 25348397 N/A physical interaction ComPPI
MCM2 TXN 25348397 N/A physical interaction ComPPI
MRFAP1 TXN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP1LC3B TXN 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DPPA4 TXN 25348397 N/A physical interaction ComPPI
DDIT4L TXN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GPRASP2 TXN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SERTAD3 TXN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TXNIP TXN 10419473 10814541 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
CASP3 TXN 17606900 24234451 25348397 protein cleavage,physical association anti bait coimmunoprecipitation,fluorescence polarization spectroscopy,isothermal titration calorimetry,pull down,physical interaction,protease assay,protein cleavage ComPPI,IntAct
COPS5 TXN 14525934 15480426 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SFPQ TXN 25348397 N/A physical interaction ComPPI
UBE2D2 TXN 25348397 N/A physical interaction ComPPI
ARHGDIA TXN 25348397 N/A physical interaction ComPPI
SIAH1 TXN 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
ACTN4 TXN 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
GAPDH TXN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ TXN 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
DLD TXN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACTN1 TXN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NTRK1 TXN 25348397 N/A physical interaction ComPPI
ENO1 TXN 25348397 N/A physical interaction ComPPI
PTPN1 TXN 24234451 24976139 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
STIP1 TXN 25348397 N/A physical interaction ComPPI
HSPA5 TXN 25348397 N/A physical interaction ComPPI
PRDX1 TXN 17557078 24234451 25348397 physical association cross-linking study,physical interaction ComPPI,IntAct
MAP3K5 TXN 12089063 14525934 19805025 21771788 24234451 25348397 9564042 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MYC TXN 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
AKR7A2 TXN 25348397 N/A physical interaction ComPPI
TXN NCF4 10397171 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
TXN GFER 14525934 15894171 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
TXN COL1A1 12099690 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
TXN DNAJA1 14525934 16458196 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TXN NR3C1 14525934 25348397 9915858 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TXN NFKB1 14525934 24234451 25348397 25609649 7788295 association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
TXN PINX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TXN VHL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TXN CD40 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TXN FST 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TXN TP53 25348397 N/A physical interaction ComPPI
TXN UCHL5 25348397 N/A physical interaction ComPPI
TXN CUL4B 25348397 N/A physical interaction ComPPI
TXN CUL2 25348397 N/A physical interaction ComPPI
TXN CDK2 25348397 N/A physical interaction ComPPI
TXN CUL1 25348397 N/A physical interaction ComPPI
TXN COPS6 25348397 N/A physical interaction ComPPI
TXN WDR1 25348397 N/A physical interaction ComPPI
TXN UBQLN4 25348397 N/A physical interaction ComPPI
TXN AHCYL1 25348397 N/A physical interaction ComPPI
TXN UBE2V1 25348397 N/A physical interaction ComPPI
TXN ATP6V1F 25348397 N/A physical interaction ComPPI
TXN SFXN1 25348397 N/A physical interaction ComPPI
TXN UBL5 25348397 N/A physical interaction ComPPI
TXN SYNCRIP 25348397 N/A physical interaction ComPPI
TXN ATIC 25348397 N/A physical interaction ComPPI
TXN UBE2K 25348397 N/A physical interaction ComPPI
TXN PAN2 25348397 N/A physical interaction ComPPI
TXN MYD88 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct
TXN DYNLT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TXN MLH1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TXN PRKN 25348397 N/A physical interaction ComPPI
TXN APEX1 10585464 11118054 14525934 24234451 25348397 8736558 9108029 N/A experimental interaction detection,physical interaction,solution state nmr ComPPI,HPRD,IntAct
TXN SRP9 25348397 N/A physical interaction ComPPI
TXN GPX1 25348397 N/A physical interaction ComPPI
TXN UNK 25348397 N/A physical interaction ComPPI
TXN CCS 25348397 N/A physical interaction ComPPI
TXN EEF2 25348397 N/A physical interaction ComPPI
TXN GLOD4 25348397 N/A physical interaction ComPPI
TXN GSTO1 25348397 N/A physical interaction ComPPI
TXN HINT1 25348397 N/A physical interaction ComPPI
TXN HSPE1 25348397 N/A physical interaction ComPPI
TXN IMPA2 25348397 N/A physical interaction ComPPI
TXN PDCD6 25348397 N/A physical interaction ComPPI
TXN PRDX2 17557078 24234451 25348397 25402766 association,physical association cross-linking study,pull down,physical interaction ComPPI,IntAct
TXN RAB1A 25348397 N/A physical interaction ComPPI
TXN SOD1 25348397 N/A physical interaction ComPPI
TXN TAGLN2 25348397 N/A physical interaction ComPPI
TXN TAGLN3 25348397 N/A physical interaction ComPPI
TXN HPF1 25348397 N/A physical interaction ComPPI
TXN ENO2 25348397 N/A physical interaction ComPPI
TXN ENO3 25348397 N/A physical interaction ComPPI
TXN GLRX5 25348397 N/A physical interaction ComPPI
TXN GSTO2 25348397 N/A physical interaction ComPPI
TXN IMPA1 25348397 N/A physical interaction ComPPI
TXN PGAM1 25348397 N/A physical interaction ComPPI
TXN PGAM2 25348397 N/A physical interaction ComPPI
TXN RAE1 25348397 N/A physical interaction ComPPI
TXN TMX1 25348397 N/A physical interaction ComPPI
TXN TYMS 25348397 N/A physical interaction ComPPI
TXN PTEN 25348397 N/A physical interaction ComPPI
TXN EWSR1 25348397 N/A physical interaction ComPPI
TXN SRPK2 25348397 N/A physical interaction ComPPI
TXN GEMIN5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TXN TOR1AIP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TXN EGFR 15657067 20029029 24234451 24658140 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction ComPPI,IntAct
TXN CRY1 25348397 N/A physical interaction ComPPI
TXN OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TXN PCGF1 25348397 N/A physical interaction ComPPI
TXN NANOGP8 25348397 N/A physical interaction ComPPI
TXN NANOG 25348397 N/A physical interaction ComPPI
TXN POU5F1 25348397 N/A physical interaction ComPPI
TXN CRBN 25348397 N/A physical interaction ComPPI
TXN DUSP13 25348397 N/A physical interaction ComPPI
TXN DUSP13 25348397 N/A physical interaction ComPPI
TXN CDK1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TXN COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TXN DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TXN PARK7 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TXN SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TXN VDAC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TXN G3BP1 25348397 N/A physical interaction ComPPI
TXN STAT3 24234451 25348397 25402766 physical association pull down,physical interaction ComPPI,IntAct
TXN TMBIM4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TXN FBXO11 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TXN EIPR1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TXN FAM107A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TXN HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TXN EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TXN MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TXN GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TXN GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TXN PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TXN VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
TXN NIF3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TXN TRAF2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TXN SPG21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TXN AIFM1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
TXN COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
TXN SHLD3 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP2K2 TXN 25348397 N/A physical interaction ComPPI
HMGB1 TXN 18996119 24234451 25348397 27898060 disulfide bond nuclear magnetic resonance ComPPI,IntAct,OmniPath
FKBP2 TXN 25348397 N/A physical interaction ComPPI
ASS1 TXN 25348397 N/A physical interaction ComPPI
NFE2 TXN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF4EBP2 TXN 25348397 N/A physical interaction ComPPI
PSPH TXN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TEX13A TXN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
METTL3 TXN 24234451 29507755 association anti tag coimmunoprecipitation IntAct
WTAP TXN 24234451 29507755 association anti tag coimmunoprecipitation IntAct
METTL14 TXN 24234451 29507755 association anti tag coimmunoprecipitation IntAct
TXN LY6E 16272220 19801666 27898060 N/A N/A OmniPath
PRKCA TXN 20619274 27898060 N/A N/A OmniPath
IL7R TXN 20167604 27898060 N/A N/A OmniPath
TXN NFKB1 18786561 27898060 7788295 inhibition,stimulant N/A OmniPath
TXN ESR1 19737086 27898060 stimulant N/A OmniPath
TXN MAP3K5 10843682 11689443 12077134 12089063 15696199 17331951 17724081 19018770 19880523 20385180 21771788 23291592 27898060 9564042 inhibition N/A OmniPath
MYD88 TXN 21988832 27898060 N/A N/A OmniPath
APEX1 TXN 10585464 11118054 18586825 27898060 8736558 9108029 stimulant N/A OmniPath
TXN SP1 19737086 27898060 stimulant N/A OmniPath
GABPA TXN 19114066 27898060 stimulant N/A OmniPath
TXN ARNT 19737086 27898060 stimulant N/A OmniPath
TXN SETD2 20347035 27898060 stimulant N/A OmniPath
TXN NR3C1 19570036 19737086 27898060 9915858 stimulant N/A OmniPath
NOX1 TXN 20347035 27898060 N/A N/A OmniPath

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