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GENE：PRKD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKD1
FullNmae protein kinase D1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9407
EnsembleID ENSG00000184304
Uniprot Q15139

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKD1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKD1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PRKD1 GO:0000421,GO:0001525,GO:0001938,GO:0004674,GO:0004674,GO:0004674,GO:0004697,GO:0004697,GO:0004698,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005794,GO:0005802,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0005911,GO:0005938,GO:0006915,GO:0006954,GO:0007030,GO:0007165,GO:0007229,GO:0007399,GO:0010508,GO:0010595,GO:0010628,GO:0010837,GO:0010976,GO:0014723,GO:0016301,GO:0018105,GO:0018105,GO:0018107,GO:0018107,GO:0018107,GO:0030018,GO:0030148,GO:0030154,GO:0031072,GO:0033138,GO:0034198,GO:0034599,GO:0035556,GO:0035924,GO:0035924,GO:0038033,GO:0042307,GO:0042802,GO:0043123,GO:0043536,GO:0043536,GO:0043552,GO:0045087,GO:0045669,GO:0045766,GO:0045766,GO:0045793,GO:0045806,GO:0045944,GO:0045944,GO:0046777,GO:0046777,GO:0046827,GO:0046872,GO:0048010,GO:0048010,GO:0048193,GO:0048471,GO:0050829,GO:0051092,GO:0051279,GO:0060298,GO:0071447,GO:0071874,GO:0089700,GO:0090277,GO:0106310,GO:1900227,GO:1904385,GO:1904628,GO:1990859,GO:2001028,GO:2001028,GO:2001044

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKD1 hsa:5587 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PRKD1 hsa:5587 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
PRKD1 hsa:5587 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DAPK1 PRKD1 17703233 21172648 26192618 interaction type N/A ACSN
PRKD1 MAP3K1 17496911 17703233 26192618 interaction type N/A ACSN
PRKD1 ADAP1 12893243 23180781 phosphorylation reaction,physical association pull down,protein kinase assay InnateDB
PRKD1 YWHAZ 12893243 23180781 physical association pull down InnateDB
PRKD1 PPP1R14A 15003508 23180781 phosphorylation reaction,physical association pull down,protein kinase assay InnateDB
PRKD1 C1QBP 10831594 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
PRKD1 TLR5 17442957 23180781 physical association anti tag coimmunoprecipitation InnateDB
PRKD1 HSPB1 18440775 23180781 phosphorylation reaction in-gel kinase assay InnateDB
YWHAQ PRKD1 10092600 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
KIDINS220 PRKD1 20005715 interaction type N/A PSP
YWHAQ PRKD1 20005715 interaction type N/A PSP
YWHAZ PRKD1 20005715 interaction type N/A PSP,SignaLink
YWHAQ PRKD1 20005715 20005715 N/A N/A SignaLink
KIDINS220 PRKD1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PRKD1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 PRKD1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PRKD1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PRKD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 PRKD1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005194EC PRKD1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC PRKD1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D PRKD1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 PRKD1 25416803 26895471 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD PRKD1 22135298 phosphorylation N/A PhosphoSite
PRKD3 PRKD1 22135298 phosphorylation N/A PhosphoSite
SRC PRKD1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKD1 HDAC7 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKD1 TCAP 22135298 phosphorylation N/A PhosphoSite
PRKD1 CERT1 22135298 phosphorylation N/A PhosphoSite
PRKD1 CTNNB1 22135298 phosphorylation N/A PhosphoSite
PRKD1 SSH1 22135298 phosphorylation N/A PhosphoSite
PRKD1 BAD 22135298 phosphorylation N/A PhosphoSite
PRKD1 HDAC5 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKD1 DLC1 22135298 phosphorylation N/A PhosphoSite
PRKD1 CREB1 22135298 phosphorylation N/A PhosphoSite
PRKD1 TLR5 22135298 phosphorylation N/A PhosphoSite
PRKD1 MARK2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKD1 RABEP1 22135298 phosphorylation N/A PhosphoSite
PRKD1 SPHK2 22135298 phosphorylation N/A PhosphoSite
PRKD1 MAP3K5 22135298 phosphorylation N/A PhosphoSite
PRKD1 PAK4 22135298 phosphorylation N/A PhosphoSite
PRKD1 AKT1 22135298 phosphorylation N/A PhosphoSite
PRKD1 PPP1R14A 22135298 phosphorylation N/A PhosphoSite
PRKD1 MYBPC3 22135298 phosphorylation N/A PhosphoSite
PRKD1 CACNA1C 22135298 phosphorylation N/A PhosphoSite
PRKD1 CTTN 22135298 phosphorylation N/A PhosphoSite
PRKD1 JUN 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKD1 PIP4K2A 22135298 phosphorylation N/A PhosphoSite
PRKD1 PTRH2 22135298 phosphorylation N/A PhosphoSite
PRKD1 ARFIP1 22135298 phosphorylation N/A PhosphoSite
PRKD1 TFAP2A 22135298 phosphorylation N/A PhosphoSite
PRKD1 PRKD1 22135298 phosphorylation N/A PhosphoSite
PRKD1 RIN1 22135298 phosphorylation N/A PhosphoSite
PRKD1 CFL1 22135298 phosphorylation N/A PhosphoSite
PRKD1 SNAI1 22135298 phosphorylation N/A PhosphoSite
PRKD1 OSBP 22135298 phosphorylation N/A PhosphoSite
PRKD1 VASP 22135298 phosphorylation N/A PhosphoSite
PRKD1 HSPB6 22135298 phosphorylation N/A PhosphoSite
PRKD1 MAP4K1 22135298 phosphorylation N/A PhosphoSite
PRKD1 TLR4 22135298 phosphorylation N/A PhosphoSite
PRKD1 HSPB1 22135298 phosphorylation N/A PhosphoSite
ABL1 PRKD1 22135298 phosphorylation N/A PhosphoSite
PRKCH PRKD1 22135298 phosphorylation N/A PhosphoSite
PRKCE PRKD1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCA PRKD1 22135298 phosphorylation N/A PhosphoSite
IGF1R PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 IGF1R 25361965 interaction type N/A PTMCode2
HDAC7 PRKD1 25361965 interaction type N/A PTMCode2
EPAS1 PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 EPAS1 25361965 interaction type N/A PTMCode2
EGFR PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 EGFR 25361965 interaction type N/A PTMCode2
CDH1 PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 CDH1 25361965 interaction type N/A PTMCode2
HDAC5 PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 PRKCE 25361965 interaction type N/A PTMCode2
PRKD1 SRC 25361965 interaction type N/A PTMCode2
PRKD1 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 PRKD1 25361965 interaction type N/A PTMCode2
JUN PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 SYK 25361965 interaction type N/A PTMCode2
SYK PRKD1 25361965 interaction type N/A PTMCode2
MARK2 PRKD1 25361965 interaction type N/A PTMCode2
YWHAQ PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 YWHAQ 25361965 interaction type N/A PTMCode2
INSR PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 INSR 25361965 interaction type N/A PTMCode2
BTK PRKD1 25361965 interaction type N/A PTMCode2
PRKD1 BTK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPK9 PRKD1 11948398 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SPRY2 PRKD1 25348397 N/A physical interaction ComPPI
SNAI1 PRKD1 25348397 N/A physical interaction ComPPI
HSP90AB1 PRKD1 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
RACK1 PRKD1 11884618 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BAD PRKD1 25348397 N/A physical interaction ComPPI
BTK PRKD1 10561498 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SYK PRKD1 14525934 25348397 8885868 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK8 PRKD1 11948398 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SRC PRKD1 12637538 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PLCG2 PRKD1 25348397 N/A physical interaction,in vivo ComPPI
JUN PRKD1 11948398 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKD1 PRKCE 10092595 14525934 19011111 24234451 25348397 phosphorylation reaction experimental interaction detection,phosphorylation reaction,protein kinase assay,in vivo ComPPI,HPRD,IntAct
PRKD1 C1QBP 10831594 14525934 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,protein kinase assay,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
PRKD1 PRKCH 10867018 11741879 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKD1 MT2A 14525934 14550308 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,beta galactosidase complementation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
PRKD1 HDAC5 11081517 11114197 14525934 15367659 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKD1 ADAP1 12893243 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKD1 PPP1R14A 14525934 15003508 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKD1 KIDINS220 10998417 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKD1 HDAC7 14525934 15623513 15738054 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKD1 EGFR 10523301 14525934 25348397 2984676 2987962 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKD1 EPAS1 14525934 17024177 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKD1 YWHAZ 25348397 N/A physical interaction ComPPI
PRKD1 PLCG1 14525934 25348397 8885868 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKD1 HSPB1 25348397 N/A physical interaction ComPPI
PRKD1 COPS7A 25348397 N/A physical interaction ComPPI
PRKD1 COPS2 25348397 N/A physical interaction ComPPI
PRKD1 COPS5 25348397 N/A physical interaction ComPPI
PRKD1 TP53 25348397 N/A physical interaction ComPPI
PRKD1 IBTK 25348397 N/A physical interaction ComPPI
PRKD1 AKAP13 25348397 N/A physical interaction ComPPI
PRKD1 HSP90AA1 25348397 N/A physical interaction ComPPI
PRKD1 HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKD1 GAN 25348397 N/A physical interaction ComPPI
PRKD1 TFAP2A 25348397 N/A physical interaction ComPPI
PRKD1 NOS1 25348397 N/A physical interaction ComPPI
PRKD1 USP28 25348397 N/A physical interaction ComPPI
PRKD1 FUCA1 25348397 N/A physical interaction ComPPI
PRKD1 SIX2 25348397 N/A physical interaction ComPPI
PRKD1 SLC9A3R2 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PRKD1 YAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PRKD1 HNRNPL 25348397 N/A physical interaction ComPPI
PRKD1 MARK2 19011111 24234451 25348397 phosphorylation reaction phosphorylation reaction,protein kinase assay ComPPI,IntAct
PRKD1 CDH1 15695390 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,protein kinase assay,confocal microscopy ComPPI,IntAct
PRKD1 MAPK13 19135240 24234451 25348397 phosphorylation reaction,association,physical association anti tag coimmunoprecipitation,protein kinase assay ComPPI,IntAct
PKM PRKD1 25348397 N/A protein kinase assay ComPPI
YWHAQ PRKD1 10092600 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IGF1R PRKD1 11884618 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HSCB PRKD1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
PRKD1 PRKD1 10831594 10867018 11741879 14525934 24234451 phosphorylation reaction experimental interaction detection,protein kinase assay HPRD,IntAct
ABL1 PRKD1 12637538 14525934 N/A experimental interaction detection HPRD
SRC PRKD1 12505989 12637538 15024053 15226414 16891660 17804414 27898060 stimulant N/A OmniPath
PRKD1 PLCG1 1370476 19651622 20068231 27898060 8885868 inhibition,stimulant N/A OmniPath
PRKCA PRKD1 10197446 10867018 11741879 11948398 15383279 15755722 27898060 stimulant N/A OmniPath
PRKD1 CTNNB1 19141652 27898060 stimulant N/A OmniPath
PRKD1 TNNI3 15514163 2226863 27898060 9346285 N/A N/A OmniPath
PRKD1 CDH1 15695390 27898060 stimulant N/A OmniPath
PRKD1 CTTN 19038333 20363754 27898060 inhibition N/A OmniPath
PRKD1 EGFR 10523301 15302935 16083266 17081983 17192257 18220336 18669648 18691976 19369195 19413330 27898060 2984676 2987962 3138233 stimulant N/A OmniPath
PRKD1 CACNA1C 22100296 22310722 27898060 stimulant N/A OmniPath
PRKD1 TRPV1 15471852 18063480 27898060 stimulant N/A OmniPath
PRKCD PRKD1 10867018 11741879 11912133 11948398 14607845 15024053 15383279 15755722 17389598 18703509 19029298 21726532 22276203 24840177 27898060 stimulant N/A OmniPath
PRKD1 ITGB4 22357621 26580203 27898060 stimulant N/A OmniPath
PRKD1 BAD 20179209 27898060 inhibition N/A OmniPath
MAPK13 PRKD1 19135240 19369195 19413330 27898060 inhibition N/A OmniPath
PRKD1 AKT1 10625301 10864894 10973320 11002428 11278872 11313365 11409731 11731414 11809760 11821945 12000752 12062056 12169689 12393602 12438236 12499277 14500543 14679308 14990993 15047168 15084259 15169778 15289327 15319269 15475446 15537647 15608670 15642728 15695828 15821749 15855334 16280327 16357520 16407838 16753042 16807298 16917505 16963136 17077177 17210635 17270736 17545609 17548608 17586693 17709744 17827393 18039660 18381446 18480058 18701889 18728186 18765673 19448664 19638206 19800394 19805619 19920202 20028775 20233713 20471940 20597130 20708153 21042280 21208159 21300025 21356307 21743495 21795477 21996732 22084251 22580611 23434580 23462102 23474758 23913047 23940660 24735537 24819169 25071014 25100728 25257795 25320242 25361894 25447541 25719244 25868858 25943101 26065416 27898060 N/A N/A OmniPath
TLR5 PRKD1 17442957 27898060 N/A N/A OmniPath
PRKD1 TLR5 17442957 20557879 27898060 stimulant N/A OmniPath
ABL1 PRKD1 10867018 11741879 12505989 12637538 20841568 27898060 stimulant N/A OmniPath
PRKD1 RIN1 11784866 18669648 21209314 27898060 inhibition N/A OmniPath
PRKD1 DLC1 21087603 27898060 inhibition N/A OmniPath
PPP1CB PRKD1 27898060 9507012 N/A N/A OmniPath
PRKD1 LATS1 15688006 27898060 N/A N/A OmniPath
PPP1CA PRKD1 27898060 9507012 N/A N/A OmniPath
PPP2CA PRKD1 27898060 9507012 inhibition N/A OmniPath
DAPK1 PRKD1 17703233 27898060 stimulant N/A OmniPath
PRKD1 SPHK2 17635916 27898060 N/A N/A OmniPath
HSPB1 PRKD1 15728188 18440775 27898060 N/A N/A OmniPath
PRKD1 HSPB1 15728188 18440775 19767773 27898060 stimulant N/A OmniPath
YWHAQ PRKD1 10092600 10831594 27898060 stimulant N/A OmniPath
PRKD1 PPP1R14A 15003508 27898060 stimulant N/A OmniPath
PRKD1 SNAI1 20940406 22276203 22791710 27898060 inhibition N/A OmniPath
PRKD1 RTKN 22228765 27898060 N/A N/A OmniPath
PRKD1 HDAC5 11081517 11114197 15367659 15728188 21081666 22865920 26137861 27898060 inhibition N/A OmniPath
PPP1CC PRKD1 27898060 9507012 N/A N/A OmniPath
PRKD1 YWHAH 11784866 27898060 stimulant N/A OmniPath
PRKD1 MAP4K1 15743830 24362026 27898060 N/A N/A OmniPath
PRKD1 HDAC7 15623513 15738054 16956611 16980613 17962809 18509061 18617643 18669648 18767875 20068231 22251793 27898060 inhibition,stimulant N/A OmniPath
PRKD1 MBP 17939756 27898060 stimulant N/A OmniPath
PRKD1 PIP4K2A 16563698 27898060 inhibition N/A OmniPath
PRKD1 MYBPC3 20151718 20850451 23277198 23619294 27898060 N/A N/A OmniPath
PRKD1 ARFIP1 22981988 23695357 25789876 27898060 stimulant N/A OmniPath
PRKD1 PTRH2 18703509 27898060 stimulant N/A OmniPath
PRKD1 TFAP2A 18845787 27898060 N/A N/A OmniPath
PRKD1 OSBP 21285358 27898060 inhibition N/A OmniPath
PPP2CB PRKD1 27898060 9507012 N/A N/A OmniPath
PRKD1 SSH1 19567672 21525957 27898060 inhibition N/A OmniPath
PRKCH PRKD1 10197446 10867018 11741879 15024053 27898060 stimulant N/A OmniPath
PRKD1 CERT1 17442665 17591919 19005213 21285358 23676904 27898060 inhibition N/A OmniPath
PRKD1 RABEP1 22975325 27898060 N/A N/A OmniPath
PRKD1 PI4KB 16100512 16606619 16912074 27898060 stimulant N/A OmniPath
PRKD1 TCAP 24280220 27898060 N/A N/A OmniPath
PRKD1 KIDINS220 10998417 18578522 18669648 20068231 27898060 stimulant N/A OmniPath

Visualization










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