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GENE：RAB8A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RAB8A
FullNmae RAB8A, member RAS oncogene family
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7007
EnsembleID ENSG00000167461
Uniprot P61006

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RAB8A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAB8A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAB8A autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
RAB8A GO:0000139,GO:0003924,GO:0003924,GO:0005515,GO:0005525,GO:0005768,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0006904,GO:0006904,GO:0006914,GO:0007030,GO:0007409,GO:0008021,GO:0009306,GO:0010506,GO:0014069,GO:0017157,GO:0019003,GO:0030140,GO:0030496,GO:0030670,GO:0031267,GO:0031489,GO:0032456,GO:0032588,GO:0032869,GO:0036064,GO:0043025,GO:0043197,GO:0045335,GO:0048169,GO:0048210,GO:0048210,GO:0051223,GO:0055038,GO:0055038,GO:0060170,GO:0060271,GO:0060271,GO:0060271,GO:0061512,GO:0070062,GO:0072659,GO:0072659,GO:0097546,GO:0097730,GO:0098887,GO:0098969,GO:0098978,GO:0099003,GO:1990782

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RAB8A hsa:4218 path:hsa04140 Autophagy - animal - Homo sapiens (human)
RAB8A hsa:4218 path:hsa04144 Endocytosis - Homo sapiens (human)
RAB8A hsa:4218 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
RAB8A hsa:4218 path:hsa04530 Tight junction - Homo sapiens (human)
RAB8A hsa:4218 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
RAB8A hsa:4218 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
RAB8A hsa:4218 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 RAB8A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RAB8A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 RAB8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RAB8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RAB8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RAB8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RAB8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RAB8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RAB8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR RAB8A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC RAB8A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 RAB8A 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000036AFF1 RAB8A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000050CCE0 RAB8A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB RAB8A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000048D44E RAB8A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 RAB8A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 RAB8A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000036B845 RAB8A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B RAB8A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC RAB8A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 RAB8A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 RAB8A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE RAB8A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F RAB8A 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EXOC5 RAB8A 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CHCHD3 RAB8A 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CDC73 RAB8A 25348397 N/A physical interaction ComPPI
TFRC RAB8A 22854040 24234451 25348397 colocalization,physical association pull down,physical interaction,confocal microscopy ComPPI,IntAct
PDE6D RAB8A 14525934 16473576 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ERLIN1 RAB8A 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RABGGTB RAB8A 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
OPTN RAB8A 11137014 14525934 20085643 20161783 20388642 20634958 22854040 23357852 24234451 25348397 27898060 colocalization,physical association two hybrid,physical interaction,confocal microscopy,bimolecular fluorescence complementation,two hybrid ComPPI,HPRD,IntAct,OmniPath
COX5A RAB8A 25348397 N/A physical interaction ComPPI
EXOC8 RAB8A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAB10 RAB8A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ANXA4 RAB8A 25348397 N/A physical interaction ComPPI
SAMM50 RAB8A 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
GDI2 RAB8A 10512627 14525934 24234451 25348397 25860027 26824392 association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
RAB8A MAP4K2 14525934 25348397 8643544 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAB8A RPH3AL 12578829 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAB8A SYTL4 11773082 12176990 12590134 14525934 23140275 24234451 24700782 25348397 26553929 26824392 27898060 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
RAB8A RPH3A 12578829 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RAB8A RAB3IP 12221131 123217 14525934 21273506 24234451 25348397 26824392 27173435 association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,tandem affinity purification,gdp/gtp exchange assay,inference by socio-affinity scoring,two hybrid ComPPI,HPRD,IntAct
RAB8A BAG6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RAB8A PQBP1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RAB8A OCRL 14525934 16902405 21378754 24234451 25348397 26824392 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,molecular sieving,pull down,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
RAB8A BIRC6 14525934 18329369 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAB8A ELAVL1 25348397 N/A physical interaction ComPPI
RAB8A SNCA 24234451 24983211 25348397 27898060 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
RAB8A RAB1B 25348397 N/A physical interaction ComPPI
RAB8A RAB7A 25348397 N/A physical interaction ComPPI
RAB8A NDUFA7 25348397 N/A physical interaction ComPPI
RAB8A SCP2 25348397 N/A physical interaction ComPPI
RAB8A IDH3G 25348397 N/A physical interaction ComPPI
RAB8A MYO5B 25348397 N/A physical interaction ComPPI
RAB8A EHD1 19864458 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RAB8A STK4 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RAB8A RPA2 25348397 N/A physical interaction ComPPI
RAB8A RPA3 25348397 N/A physical interaction ComPPI
RAB8A STAU1 25348397 N/A physical interaction ComPPI
RAB8A SYTL1 25348397 N/A physical interaction ComPPI
RAB8A TBC1D17 22854040 24234451 25348397 colocalization,association anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
RAB8A SHMT2 25348397 N/A physical interaction ComPPI
RAB8A ODF2 17646400 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RAB8A SRPRB 25348397 N/A physical interaction ComPPI
RAB8A RAB5A 25348397 N/A physical interaction ComPPI
RAB8A RAB5B 25348397 N/A physical interaction ComPPI
RAB8A RAB5C 25348397 N/A physical interaction ComPPI
RAB8A RAP1A 25348397 N/A physical interaction ComPPI
RAB8A RAP1B 25348397 N/A physical interaction ComPPI
RAB8A SDHB 25348397 N/A physical interaction ComPPI
RAB8A MDM2 25348397 N/A physical interaction ComPPI
RAB8A DCTN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RAB8A GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB8A RAB3B 25348397 N/A physical interaction ComPPI
RAB8A MTMR4 25348397 N/A physical interaction ComPPI
RAB8A RAB8B 24234451 25348397 26824392 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB8A RAB1A 24234451 25348397 26824392 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB8A NDUFA10 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
RAB8A NDUFA5 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
RAB8A RANBP10 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAB8A RANBP9 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAB8A BIN1 25348397 N/A physical interaction ComPPI
RAB8A EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RAB8A ARF6 21951725 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
RAB8A TRIM25 24234451 24515439 25348397 colocalization fluorescence microscopy ComPPI,IntAct
RAB8A CTLA4 24234451 24515439 25348397 colocalization fluorescence microscopy ComPPI,IntAct
RAB8A LAX1 24234451 24515439 25348397 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
RAB8A LRRK2 24234451 25348397 26824392 phosphorylation reaction,association,physical association anti tag coimmunoprecipitation,protein kinase assay ComPPI,IntAct
RAB8A MICAL1 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A DVL2 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A GBF1 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A RAB6A 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A MICALL2 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A RAB18 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A CHM 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A MICALL1 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A RABGGTA 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A ARL1 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A ARF1 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RAB8A VAPA 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
RPA1 RAB8A 25348397 N/A physical interaction ComPPI
GDI1 RAB8A 24234451 25348397 26496610 26824392 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VAMP3 RAB8A 25348397 N/A physical interaction ComPPI
ARF4 RAB8A 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
HSP90B1 RAB8A 24234451 30021884 physical association cross-linking study IntAct
RPGR RAB8A 20631154 27898060 stimulant N/A OmniPath

Visualization










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