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GENE：PTPN13

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PTPN13
FullNmae protein tyrosine phosphatase non-receptor type 13
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9646
EnsembleID ENSG00000163629
Uniprot Q12923

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PTPN13 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PTPN13 GO:0001650,GO:0001933,GO:0004725,GO:0004725,GO:0004725,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0006470,GO:0030027,GO:0035335,GO:0035335,GO:0036312,GO:0036312,GO:0044297,GO:0051896,GO:0070062,GO:0097237,GO:1904890

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PTPN13 hsa:5783 path:hsa04210 Apoptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PTPN13 FAS 12702723 12724420 16498403 18195016 23069999 23180781 26192618 9184224 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
PTPN13 FASLG 12702723 12724420 16498403 23069999 26192618 9184224 interaction type N/A ACSN
PTPN13 FAF1 12702723 12724420 16498403 23069999 26192618 9184224 interaction type N/A ACSN
PTPN13 FADD 12702723 12724420 16498403 23069999 26192618 9184224 interaction type N/A ACSN
PTPN13 DAXX 12702723 12724420 16498403 23069999 26192618 9184224 interaction type N/A ACSN
PTPN13 RIPK1 12702723 12724420 16498403 23069999 26192618 9184224 interaction type N/A ACSN
NFKBIA PTPN13 11106428 23180781 dephosphorylation reaction,physical association affinity chromatography technology,gst pull down,dephosphorylation reaction InnateDB
PTPN13 TRIP6 10400701 17591779 23180781 dephosphorylation reaction,physical association anti tag coimmunoprecipitation,two hybrid,pull down,in gel phosphatase assay InnateDB
PTPN13 IRF8 18195016 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTPN13 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PTPN13 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 PTPN13 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PTPN13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PTPN13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PTPN13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB PTPN13 11696979 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 PTPN13 11696979 16306044 trascriptional regulation,stimulation inferred by curator TFlink
RELA PTPN13 11696979 16306044 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 PTPN13 24191246 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PTPN13 11696979 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000171525 PTPN13 20620960 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000171525 PTPN13 20620960 22743998 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00001597DC PTPN13 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 PTPN13 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PDCD10 PTPN13 17657516 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,pull down ComPPI,IntAct
EGLN3 PTPN13 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CBY1 PTPN13 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RTKN PTPN13 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GIGYF1 PTPN13 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PRKACA PTPN13 14525934 15371306 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PKN2 PTPN13 11356191 14525934 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
YWHAB PTPN13 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ PTPN13 14525934 25348397 7536343 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
GHR PTPN13 25348397 N/A physical interaction ComPPI
APC PTPN13 10951583 14525934 17240990 24234451 25348397 N/A two hybrid,experimental interaction detection,isothermal titration calorimetry,in vitro,two hybrid ComPPI,HPRD,IntAct
HEY1 PTPN13 25348397 N/A physical interaction ComPPI
NFKBIA PTPN13 11106428 14525934 14743216 24234451 25348397 9882613 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
TRIP6 PTPN13 10400701 10826496 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
HNRNPL PTPN13 25348397 N/A physical interaction ComPPI
RGS2 PTPN13 25348397 N/A physical interaction ComPPI
SQSTM1 PTPN13 24234451 24316673 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FADD PTPN13 14525934 16498403 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAPGEF6 PTPN13 12095257 14525934 14698303 17240990 20430886 24234451 25348397 27898060 association biophysical,two hybrid,experimental interaction detection,isothermal titration calorimetry,nuclear magnetic resonance,x-ray crystallography,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
EFNB2 PTPN13 14525934 25348397 9920925 N/A experimental interaction detection,in vitro ComPPI,HPRD
EPS15 PTPN13 25348397 N/A dephosphorylation reaction,phosphatase assay ComPPI
TUBA1A PTPN13 24234451 25348397 27291054 association pull down ComPPI,IntAct
FASLG PTPN13 14525934 16498403 25348397 9261095 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
STXBP4 PTPN13 25348397 N/A physical interaction ComPPI
NGFR PTPN13 10544233 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EFNB1 PTPN13 14525934 25348397 9920925 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SH3PXD2A PTPN13 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CTNNB1 PTPN13 10951583 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTEN PTPN13 25348397 N/A physical interaction ComPPI
BEX3 PTPN13 10544233 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN13 CRIP2 12839623 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PTPN13 ARHGAP29 14525934 25348397 9305890 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTPN13 BRD7 10526152 25348397 27898060 N/A two hybrid,in vivo ComPPI,OmniPath
PTPN13 PLEKHA1 14516276 14525934 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro ComPPI,HPRD,IntAct
PTPN13 PDLIM4 10826496 11884147 14525934 15663004 24234451 25348397 colocalization two hybrid,experimental interaction detection,fluorescence technology,in vitro,two hybrid ComPPI,HPRD,IntAct
PTPN13 FAS 10918185 12724420 14525934 24234451 25348397 7536343 9079683 9835052 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PTPN13 FBXL2 25348397 N/A physical interaction ComPPI
PTPN13 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN13 LATS2 25348397 N/A physical interaction ComPPI
PTPN13 RAPGEF2 25348397 N/A physical interaction ComPPI
PTPN13 RASSF10 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN13 NSD2 25348397 N/A physical interaction ComPPI
PTPN13 FBXW11 25348397 N/A physical interaction ComPPI
PTPN13 DNM2 25348397 N/A physical interaction ComPPI
PTPN13 NINL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN13 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PTPN13 DFFB 25348397 N/A physical interaction ComPPI
PTPN13 KCTD3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 KIF13B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 CGN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 ZBTB21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 KSR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 LPIN3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 LRFN1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 DENND4C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 MAST3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 SH3RF3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 DENND1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 SRGAP2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 PPM1H 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 TANC2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 RALGPS2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 EIF4E2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 SIPA1L1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 GIGYF2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 INPP5E 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 MTNR1A 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
PTPN13 PLEKHA2 14516276 24234451 25348397 physical association pull down ComPPI,IntAct
PTPN13 STK25 25348397 N/A phosphatase assay ComPPI
PTPN13 TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
PTPN13 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LRFN4 PTPN13 22677168 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PTPN13 TRPM2 17251321 27898060 inhibition N/A OmniPath
PTPN13 IRS1 17638892 27898060 inhibition N/A OmniPath
PTPN13 NFKBIA 11106428 14743216 27898060 9882613 inhibition,stimulant N/A OmniPath
FAS PTPN13 10918185 12724420 18195016 27898060 7536343 9079683 9835052 N/A N/A OmniPath
PTPN13 FAS 10918185 12724420 18195016 27898060 7536343 9079683 9835052 inhibition N/A OmniPath
PTPN13 INSR 15611135 27898060 inhibition N/A OmniPath
PTPN13 PKN2 11356191 27898060 N/A N/A OmniPath
PTPN13 NGFR 10544233 27898060 N/A N/A OmniPath
PTPN13 TRIP6 10400701 10826496 17591779 27898060 N/A N/A OmniPath
PTPN13 STK25 17657516 27898060 inhibition N/A OmniPath
PTPN13 MBP 27898060 7929060 N/A N/A OmniPath
PTPN13 EFNB1 27898060 9920925 stimulant N/A OmniPath
PTPN13 ARHGAP29 27898060 9305890 N/A N/A OmniPath
PTPN13 PDCD10 17657516 27898060 inhibition N/A OmniPath

Visualization










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