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GENE：ROCK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ROCK1
FullNmae Rho associated coiled-coil containing protein kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10251
EnsembleID ENSG00000067900
Uniprot Q13464

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ROCK1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ROCK1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ROCK1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ROCK1 apoptosis 33297931 Meanwhile, the up-regulation of the ROCK1 gene was associated with H(2)O(2)-induced HLE-B3 cells apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
ROCK1 GO:0000139,GO:0000281,GO:0001726,GO:0001837,GO:0003180,GO:0003383,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005814,GO:0005829,GO:0005856,GO:0005856,GO:0005886,GO:0006468,GO:0006939,GO:0007159,GO:0007165,GO:0007249,GO:0007266,GO:0007266,GO:0010494,GO:0010494,GO:0010506,GO:0010508,GO:0010613,GO:0010628,GO:0010628,GO:0010922,GO:0016525,GO:0018105,GO:0018107,GO:0019828,GO:0022614,GO:0030027,GO:0030036,GO:0030155,GO:0030334,GO:0030866,GO:0030866,GO:0030866,GO:0031032,GO:0031175,GO:0031267,GO:0032059,GO:0032060,GO:0032091,GO:0032956,GO:0032956,GO:0032956,GO:0034774,GO:0035306,GO:0035509,GO:0035509,GO:0042326,GO:0043410,GO:0045616,GO:0045664,GO:0046872,GO:0048156,GO:0048598,GO:0050321,GO:0050900,GO:0050901,GO:0051045,GO:0051451,GO:0051492,GO:0051893,GO:0051894,GO:0061157,GO:0070168,GO:0070507,GO:0071559,GO:0072518,GO:0072518,GO:0072659,GO:0072659,GO:0090128,GO:0090521,GO:0097049,GO:0097746,GO:0098685,GO:0106310,GO:0110061,GO:0140058,GO:1900223,GO:1900242,GO:1901888,GO:1902003,GO:1902430,GO:1902992,GO:1903140,GO:1903140,GO:1903347,GO:1905205,GO:1990776,GO:2000114,GO:2000145,GO:2000672

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ROCK1 hsa:6093 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04360 Axon guidance - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04510 Focal adhesion - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04520 Adherens junction - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04530 Tight junction - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04611 Platelet activation - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa05131 Shigellosis - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa05135 Yersinia infection - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ROCK1 hsa:6093 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ROCK1 MYH9 10652353 11698448 12194823 12778124 19349987 26192618 27785353 interaction type N/A ACSN
ROCK1 LIMK1 10652353 11698448 12194823 12778124 19349987 26192618 27785353 interaction type N/A ACSN
ROCK1 PTEN 10652353 11698448 12194823 12778124 19349987 20008297 22074495 26192618 27785353 interaction type N/A ACSN
RHOA ROCK1 11698448 11729192 11739775 11992112 12194823 12361600 12727213 12740575 14657501 14744429 15761148 17517963 17673200 18037882 18423981 20535745 21178402 22949611 23109003 24857661 24919149 26192618 26885855 27048821 27066895 7479854 9362522 9660866 9822605 interaction type,chemical activation reaction N/A ACSN,SignaLink
CD44 ROCK1 15090545 23180781 physical association anti tag coimmunoprecipitation InnateDB
ROCK1 ROCK1 15068801 26467481 phosphorylation reaction,up-regulates activity N/A Signor
DVL1 ROCK1 15121866 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CFL1 ROCK1 20005715 interaction type N/A PSP,SignaLink
GAB1 ROCK1 20005715 interaction type N/A PSP
IRS1 ROCK1 20005715 interaction type N/A PSP
GAB1 ROCK1 12748184 20005715 20005715 21071413 N/A N/A SignaLink
IRS1 ROCK1 11739394 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ROCK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ROCK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ROCK1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ROCK1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IGF1R ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ROCK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001EFBE3 ROCK1 18174313 \N rna interference,inhibition experimental interaction detection,western blot,northern blot,miRNA interference luciferase reporter assay miRSponge
URS0000521626 ROCK1 23238785 rna interference,inhibition western blot miRSponge
URS000006BE7D ROCK1 21119662 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 ROCK1 18174313 18927107 25416803 26306811 27221467 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000006BE7D ROCK1 21119662 25416803 26715733 mrna cleavage,inhibition array technology,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000521626 ROCK1 23233531 23238785 25416803 26530325 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 ROCK1 23975506 25416803 27035227 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BBF48 ROCK1 21994419 23670799 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00004F4657 ROCK1 24573110 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000007FBA ROCK1 23872151 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000215483 ROCK1 22100165 22291592 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 ROCK1 22100165 22291592 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C ROCK1 22100165 22291592 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B ROCK1 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 ROCK1 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 ROCK1 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 ROCK1 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 ROCK1 25416803 26474697 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001D69F6 ROCK1 25416803 27108693 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002E92A8 ROCK1 25416803 25912304 26458302 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ROCK1 SCRIB 22135298 phosphorylation N/A PhosphoSite
ROCK1 MARCKS 22135298 phosphorylation N/A PhosphoSite
ROCK1 RDX 22135298 phosphorylation N/A PhosphoSite
ROCK1 RND3 22135298 phosphorylation N/A PhosphoSite
ROCK1 SLC9A1 22135298 phosphorylation N/A PhosphoSite
ROCK1 ARHGAP35 22135298 phosphorylation N/A PhosphoSite
ROCK1 FHOD1 22135298 phosphorylation N/A PhosphoSite
ROCK1 ARHGAP24 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 EZR 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 GFAP 22135298 phosphorylation N/A PhosphoSite
ROCK1 PTEN 22135298 phosphorylation N/A PhosphoSite
ROCK1 DES 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 MYL12B 22135298 phosphorylation N/A PhosphoSite
ROCK1 DPYSL2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 PRMT5 22135298 phosphorylation N/A PhosphoSite
ROCK1 MYL9 22135298 phosphorylation N/A PhosphoSite
ROCK1 PFN1 22135298 phosphorylation N/A PhosphoSite
ROCK1 ADD1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 H3C1 22135298 phosphorylation N/A PhosphoSite
ROCK1 MSN 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 LIMK2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 PPP1R12B 22135298 phosphorylation N/A PhosphoSite
ROCK1 DAPK3 22135298 phosphorylation N/A PhosphoSite
ROCK1 VIM 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 PTK2 22135298 phosphorylation N/A PhosphoSite
ROCK1 LIMK1 22135298 phosphorylation N/A PhosphoSite
ROCK1 SOX9 22135298 phosphorylation N/A PhosphoSite
ROCK1 PPP1R12A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK1 MAPK8IP3 22135298 phosphorylation N/A PhosphoSite
MSN ROCK1 25361965 interaction type N/A PTMCode2
LIMK2 ROCK1 25361965 interaction type N/A PTMCode2
ARHGAP24 ROCK1 25361965 interaction type N/A PTMCode2
VIM ROCK1 25361965 interaction type N/A PTMCode2
CASP3 ROCK1 25361965 interaction type N/A PTMCode2
ROCK1 CASP3 25361965 interaction type N/A PTMCode2
DES ROCK1 25361965 interaction type N/A PTMCode2
EZR ROCK1 25361965 interaction type N/A PTMCode2
PPP1R12A ROCK1 25361965 interaction type N/A PTMCode2
IRS1 ROCK1 25361965 interaction type N/A PTMCode2
ROCK1 IRS1 25361965 interaction type N/A PTMCode2
DPYSL2 ROCK1 25361965 interaction type N/A PTMCode2
ADD1 ROCK1 25361965 interaction type N/A PTMCode2
ROCK1 ROCK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DES ROCK1 10574968 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CFAP206 ROCK1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAGEB4 ROCK1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VIM ROCK1 14525934 25348397 9565595 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CFL1 ROCK1 25348397 N/A physical interaction ComPPI
ROCK1 PFN2 14517206 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ROCK1 RDX 14525934 25348397 9456324 N/A experimental interaction detection,in vitro ComPPI,HPRD
ROCK1 MSN 14525934 25348397 9516463 9856983 N/A experimental interaction detection,in vitro ComPPI,HPRD
ROCK1 CASP3 11283607 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ROCK1 LIMK1 10436159 10559936 10652353 11340065 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ROCK1 LIMK2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
ROCK1 PPP1R12A 10601309 11931630 12220642 12563012 12600888 14525934 25348397 9354661 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ROCK1 DPYSL2 10818093 12482610 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ROCK1 RND3 12773565 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ROCK1 CDC25A 14525934 14657354 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ROCK1 CRMP1 12482610 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ROCK1 IRS1 11739394 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ROCK1 EZR 10970850 11387207 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ROCK1 ARHGAP24 14525934 16862148 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ROCK1 TSG101 14525934 17853893 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
ROCK1 ADD1 10209029 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ROCK1 GFAP 14525934 2114109 2155236 25348397 7822264 9099667 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ROCK1 SMAD2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ROCK1 GAB1 25348397 N/A physical interaction ComPPI
ROCK1 HNRNPA1 25348397 N/A physical interaction ComPPI
ROCK1 ITSN2 25348397 N/A physical interaction ComPPI
ROCK1 ARRB1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROCK1 NOTCH1 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ROCK1 SMURF1 25348397 N/A physical interaction ComPPI
ROCK1 CASP7 25348397 N/A physical interaction ComPPI
ROCK1 CDK15 25348397 N/A physical interaction ComPPI
ROCK1 ANKFY1 25348397 N/A physical interaction ComPPI
ROCK1 MON2 25348397 N/A physical interaction ComPPI
ROCK1 WASHC2A 25348397 N/A physical interaction ComPPI
ROCK1 WASHC4 25348397 N/A physical interaction ComPPI
ROCK1 IKBKB 25348397 N/A physical interaction ComPPI
ROCK1 LMO2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ROCK1 FAM124A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ROCK1 NXF1 25348397 N/A physical interaction ComPPI
ROCK1 NTRK1 25348397 N/A physical interaction ComPPI
ROCK1 MED23 25348397 N/A physical interaction ComPPI
ROCK1 XRCC5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROCK1 NEIL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROCK1 TRIM15 25348397 N/A physical interaction ComPPI
ROCK1 HGS 25348397 N/A physical interaction ComPPI
ROCK1 SLC9A1 25348397 N/A physical interaction ComPPI
ROCK1 UBE2T 25348397 N/A physical interaction ComPPI
ROCK1 CDKN3 25348397 N/A physical interaction ComPPI
ROCK1 TNS2 25348397 N/A physical interaction ComPPI
ROCK1 ROCK2 25348397 N/A physical interaction ComPPI
ROCK1 ADD2 25348397 N/A physical interaction ComPPI
ROCK1 IL20RA 25348397 N/A physical interaction ComPPI
ROCK1 CYLD 25348397 N/A physical interaction ComPPI
ROCK1 MYH9 24234451 25348397 26368311 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROCK1 NCL 21281639 24234451 25348397 association pull down ComPPI,IntAct
ROCK1 NEB 21281639 24234451 25348397 association pull down ComPPI,IntAct
ROCK1 HSPA1A 21281639 24234451 25348397 association pull down ComPPI,IntAct
ROCK1 HSPA1B 25348397 N/A pull down ComPPI
ROCK1 HSP90AB1 21281639 24234451 25348397 association pull down ComPPI,IntAct
ROCK1 MYBPH 22085929 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
ROCK1 FRMD5 24234451 25348397 25448675 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
ROCK1 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
POLR3C ROCK1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RHOC ROCK1 14525934 25348397 8816443 N/A experimental interaction detection,in vivo ComPPI,HPRD
RHOA ROCK1 14525934 14660612 21281639 24234451 25348397 8798490 association,physical association two hybrid,experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
CDC34 ROCK1 14525934 16123592 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ROCK1 ROCK1 14525934 16249185 24234451 N/A experimental interaction detection,x-ray crystallography HPRD,IntAct
PDPK1 ROCK1 18204440 27898060 N/A N/A OmniPath
RHOA ROCK1 12773565 14660612 15774750 17145710 21281639 22430126 23151663 25010901 27898060 8798490 8816443 9535835 stimulant N/A OmniPath
ROCK1 PTEN 12297295 15793569 27898060 stimulant N/A OmniPath
ROCK1 DES 10574968 27898060 N/A N/A OmniPath
ROCK1 MYL9 27898060 8702756 stimulant N/A OmniPath
CASP3 ROCK1 11283607 27898060 stimulant N/A OmniPath
ROCK1 GFAP 12686604 2114109 2155236 27898060 7822264 9099667 N/A N/A OmniPath
ROCK1 LIMK2 10652353 11018042 11340065 22492986 27898060 stimulant N/A OmniPath
ROCK1 PPP1R12A 10601309 10926869 11384979 11719507 11739394 11931630 12220642 12563012 12600888 12919947 15003930 15281089 15723050 17525332 18077418 18212344 18669648 18767875 19701943 19997641 27898060 8662509 9354661 inhibition,stimulant N/A OmniPath
ROCK1 MYH10 15774750 27898060 stimulant N/A OmniPath
ROCK1 H3C1 11441012 12082625 12686604 15010460 15681610 15684425 16407273 16452462 16457588 17158874 17644761 18418070 19407812 19956839 20089855 20864036 21282660 21514157 21804608 21820363 22158034 25547114 25553095 27898060 N/A N/A OmniPath
ROCK1 PTK2 15247219 16760434 27898060 stimulant N/A OmniPath
ROCK1 EZR 10970850 11387207 19255442 19386264 27898060 stimulant N/A OmniPath
ROCK1 SOX9 10805756 11120880 19470758 20039424 21818404 27898060 stimulant N/A OmniPath
ROCK1 ARHGAP35 19103606 19673492 27898060 inhibition N/A OmniPath
ROCK1 VIM 11895474 15713670 15766329 16990256 16997882 18669648 19007248 19270731 20068231 20166139 22345628 22795529 23737341 27898060 9565595 stimulant N/A OmniPath
DVL1 ROCK1 15121866 27898060 stimulant N/A OmniPath
ROCK1 LIMK1 10436159 10559936 10652353 11018042 11340065 11784854 15660133 16641196 18332102 20696146 21693580 25486435 25544611 25714010 27898060 stimulant N/A OmniPath
ROCK1 DAPK3 15611134 16325270 17158456 18239682 27898060 stimulant N/A OmniPath
ROCK1 MAPK8 15068801 27898060 stimulant N/A OmniPath
ROCK1 MYL12A 11283607 12185584 27898060 8702756 stimulant N/A OmniPath
ROCK1 NFATC4 15657420 27898060 N/A N/A OmniPath
ROCK1 PFN1 18573880 22479341 25084196 25681442 27898060 inhibition N/A OmniPath
ROCK1 MAPK8IP3 15767678 19036714 27898060 stimulant N/A OmniPath
ROCK1 MYLK 11283607 27898060 inhibition,stimulant N/A OmniPath
ROCK1 PPP1R12B 16431080 22937917 27898060 inhibition N/A OmniPath
ROCK1 RDX 20068231 27898060 9456324 stimulant N/A OmniPath
ROCK1 ADD1 10209029 27898060 stimulant N/A OmniPath
ROCK1 ARHGAP24 16862148 26359494 27898060 stimulant N/A OmniPath
ROCK1 FHOD1 18239683 27898060 stimulant N/A OmniPath
ROCK1 ADD2 16116087 27898060 8810272 9679146 N/A N/A OmniPath
ROCK1 KCNK3 21838752 27898060 inhibition N/A OmniPath
ROCK1 MYL12B 12185584 27898060 stimulant N/A OmniPath
ROCK1 RND3 12773565 15775972 27898060 stimulant N/A OmniPath
ROCK1 MPRIP 17761936 27898060 inhibition N/A OmniPath
ROCK1 MYOM1 27898060 9029142 stimulant N/A OmniPath

Visualization










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