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GENE：SEC22B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SEC22B
FullNmae SEC22 homolog B, vesicle trafficking protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10700
EnsembleID ENSG00000265808
Uniprot O75396

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SEC22B autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SEC22B autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SEC22B GO:0000139,GO:0000139,GO:0005484,GO:0005515,GO:0005789,GO:0005789,GO:0005793,GO:0005793,GO:0006888,GO:0006890,GO:0012507,GO:0012507,GO:0012507,GO:0015031,GO:0030133,GO:0030670,GO:0031201,GO:0033116,GO:0042470,GO:0045732,GO:0048280,GO:1902902

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SEC22B hsa:9554 path:hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human)
SEC22B hsa:9554 path:hsa04145 Phagosome - Homo sapiens (human)
SEC22B hsa:9554 path:hsa05134 Legionellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SEC22B RNF2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
SEC22B ADRB2 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SEC22B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SEC22B 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SEC22B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SEC22B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SEC22B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink

Source Target Pmid Interactiontype Methods Database
VAMP2 SEC22B 25348397 N/A physical interaction ComPPI
STX12 SEC22B 25348397 N/A physical interaction ComPPI
RELL2 SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ISG15 SEC22B 24234451 25348397 26259872 association pull down ComPPI,IntAct
UBL4A SEC22B 25348397 N/A physical interaction ComPPI
VCP SEC22B 25348397 N/A physical interaction ComPPI
LMNA SEC22B 25348397 N/A physical interaction ComPPI
MCM2 SEC22B 25348397 N/A physical interaction ComPPI
RINT1 SEC22B 25348397 N/A physical interaction ComPPI
S100A16 SEC22B 25348397 N/A physical interaction ComPPI
ZYX SEC22B 25348397 N/A physical interaction ComPPI
TMEM139 SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SERPINH1 SEC22B 25348397 N/A physical interaction ComPPI
CANX SEC22B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IFNGR2 SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XRCC1 SEC22B 25348397 N/A physical interaction ComPPI
SIN3A SEC22B 25348397 N/A physical interaction ComPPI
RPA1 SEC22B 25348397 N/A physical interaction ComPPI
PDHA1 SEC22B 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
STX4 SEC22B 22153078 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATP6AP2 SEC22B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA2 SEC22B 25348397 N/A physical interaction ComPPI
RPA3 SEC22B 25348397 N/A physical interaction ComPPI
TST SEC22B 25348397 N/A physical interaction ComPPI
STX1A SEC22B 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ADRB2 SEC22B 25348397 N/A physical interaction ComPPI
VAPB SEC22B 25348397 N/A physical interaction ComPPI
NAPA SEC22B 25348397 N/A physical interaction ComPPI
STX8 SEC22B 25348397 N/A physical interaction ComPPI
VHL SEC22B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RNF2 SEC22B 25348397 N/A physical interaction ComPPI
OCRL SEC22B 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CREB3 SEC22B 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
STX7 SEC22B 25348397 N/A physical interaction ComPPI
EBP SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CUL7 SEC22B 25348397 N/A physical interaction ComPPI
SUCLG2 SEC22B 25348397 N/A physical interaction ComPPI
SUCLA2 SEC22B 25348397 N/A physical interaction ComPPI
BNIP1 SEC22B 21550981 25348397 27898060 9214619 N/A physical interaction ComPPI,OmniPath
ABHD16A SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM25 SEC22B 25348397 N/A physical interaction ComPPI
ELAVL1 SEC22B 25348397 N/A physical interaction ComPPI
CLDN7 SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX5 SEC22B 11035026 15029241 22153078 24234451 24705552 25348397 27898060 9166403 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,in vitro ComPPI,IntAct,OmniPath
DERL1 SEC22B 25348397 N/A physical interaction ComPPI
ESR1 SEC22B 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
ESR2 SEC22B 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
SEPTIN9 SEC22B 25348397 N/A physical interaction ComPPI
GOSR1 SEC22B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STX6 SEC22B 25348397 N/A physical interaction ComPPI
UBE2M SEC22B 25348397 N/A physical interaction ComPPI
GOSR2 SEC22B 25348397 N/A physical interaction ComPPI
SEC22B STX18 19369418 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SEC22B TMED10 25348397 N/A physical interaction ComPPI
SEC22B SEPTIN11 25348397 N/A physical interaction ComPPI
SEC22B TCOF1 25348397 N/A physical interaction ComPPI
SEC22B STIM1 25348397 N/A physical interaction ComPPI
SEC22B TMED9 25348397 N/A physical interaction ComPPI
SEC22B SMARCA2 25348397 N/A physical interaction ComPPI
SEC22B SART1 25348397 N/A physical interaction ComPPI
SEC22B UBXN1 25348397 N/A physical interaction ComPPI
SEC22B MPST 25348397 N/A physical interaction ComPPI
SEC22B CPS1 25348397 N/A physical interaction ComPPI
SEC22B PEDS1 25348397 N/A physical interaction ComPPI
SEC22B TMEM9 25348397 N/A physical interaction ComPPI
SEC22B TACO1 25348397 N/A physical interaction ComPPI
SEC22B VPS29 25348397 N/A physical interaction ComPPI
SEC22B TIMM9 25348397 N/A physical interaction ComPPI
SEC22B FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
SEC22B ATP4A 25348397 N/A physical interaction ComPPI
SEC22B B3GAT3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SEC22B OBSL1 25348397 N/A physical interaction ComPPI
SEC22B CCDC8 25348397 N/A physical interaction ComPPI
SEC22B UBAC2 25348397 N/A physical interaction ComPPI
SEC22B TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SEC22B TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SEC22B TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SEC22B TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SEC22B ATL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC22B GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC22B CENPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC22B USE1 25348397 N/A physical interaction ComPPI
SEC22B SCFD2 25348397 N/A physical interaction ComPPI
SEC22B NBAS 25348397 N/A physical interaction ComPPI
SEC22B BET1 11251068 11959998 11994317 16303754 24234451 25348397 27898060 29568061 8063853 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct,OmniPath
SEC22B WASHC4 25348397 N/A physical interaction ComPPI
SEC22B UGT8 25348397 N/A physical interaction ComPPI
SEC22B SNAP47 25348397 N/A physical interaction ComPPI
SEC22B VTI1B 25348397 N/A physical interaction ComPPI
SEC22B NAPG 25348397 N/A physical interaction ComPPI
SEC22B C19ORF25 25348397 N/A physical interaction ComPPI
SEC22B ZW10 25348397 N/A physical interaction ComPPI
SEC22B FAM234B 25348397 N/A physical interaction ComPPI
SEC22B SCFD1 25348397 N/A physical interaction ComPPI
SEC22B STX10 25348397 N/A physical interaction ComPPI
SEC22B SLC39A3 25348397 N/A physical interaction ComPPI
SEC22B SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SEC22B LNX1 25348397 N/A physical interaction ComPPI
SEC22B IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SEC22B GJB5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B TMEM167B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B MFSD5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B MRPS18B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B REEP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B HSD17B11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B MMGT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B KIR2DL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B GJB6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B GORAB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B MGST2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B CPLX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B FNDC9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B RHBDD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B TLCD4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B GPR152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B LHFPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B TM4SF19 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B CLRN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B TMEM229B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B HIBADH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B ELOVL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B FAM174A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B NDUFAF2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22B LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM86B SEC22B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
METTL14 SEC22B 24234451 29507755 association anti tag coimmunoprecipitation IntAct
STK38L SEC22B 24234451 30108113 association proximity-dependent biotin identification IntAct
PCLO SEC22B 24234451 30021884 physical association cross-linking study IntAct
SEC22B MNX1 24234451 30021884 physical association cross-linking study IntAct
SEC22B CREB1 24234451 30021884 physical association cross-linking study IntAct
SEC22B ERO1B 24234451 30021884 physical association cross-linking study IntAct
SEC22B PBX4 24234451 30021884 physical association cross-linking study IntAct
SEC22B SERPINA5 24234451 30021884 physical association cross-linking study IntAct
SEC22B CFHR5 24234451 30021884 physical association cross-linking study IntAct
SEC22B SGTB 20850366 21835666 27898060 N/A N/A OmniPath

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