GENE：SESN1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SESN1 |
| FullNmae | sestrin 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:21595 |
| EnsembleID | ENSG00000080546 |
| Uniprot | Q9Y6P5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SESN1 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SESN1 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SESN1 | GO:0001650,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016239,GO:0016684,GO:0034198,GO:0042149,GO:0070728,GO:0070728,GO:0071233,GO:0072593,GO:0098869,GO:1901031,GO:1904262,GO:1904262,GO:1990253 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SESN1 | hsa:27244 | path:hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| SESN1 | hsa:27244 | path:hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SESN1 | 16751804 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | SESN1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | SESN1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | SESN1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | SESN1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TFAP2C | SESN1 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SESN1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SESN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | SESN1 | 17991735 | rna interference,inhibition | array technology,quantitative reverse transcription pcr | miRSponge |
| URS000009262D | SESN1 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000ED600 | SESN1 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | SESN1 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000007F792 | SESN1 | 24374217 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000008931A | SESN1 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001925C1 | SESN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000012A1DD | SESN1 | 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171525 | SESN1 | 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000058863C | SESN1 | 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000055BBE5 | SESN1 | 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000009265 | SESN1 | 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000292B1 | SESN1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | SESN1 | 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000002103A | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F2EB0 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A79D1 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000116F83 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001919B0 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EEE35 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000544FF1 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000209F04 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | SESN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KEAP1 | SESN1 | 23274085 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RBX1 | SESN1 | 25348397 | N/A | physical interaction | ComPPI |
| PRDX1 | SESN1 | 14525934 15105503 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| HNRNPL | SESN1 | 25348397 | N/A | physical interaction | ComPPI |
| SQSTM1 | SESN1 | 23274085 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SESN1 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| TP53 | SESN1 | 18431400 27898060 | stimulant | N/A | OmniPath |
| PBX1 | SESN1 | 23274085 27898060 | N/A | N/A | OmniPath |