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GENE：SESN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SESN2
FullNmae sestrin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20746
EnsembleID ENSG00000130766
Uniprot P58004

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SESN2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SESN2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SESN2 GO:0001932,GO:0004601,GO:0005092,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005765,GO:0005829,GO:0006111,GO:0006635,GO:0009749,GO:0016239,GO:0016239,GO:0016684,GO:0030308,GO:0030330,GO:0032042,GO:0032542,GO:0032868,GO:0034198,GO:0034599,GO:0042149,GO:0042593,GO:0042731,GO:0043491,GO:0044877,GO:0046323,GO:0070328,GO:0070728,GO:0070728,GO:0071230,GO:0071233,GO:0071233,GO:0071233,GO:0072593,GO:0072593,GO:0098869,GO:0098869,GO:0140311,GO:1900182,GO:1901031,GO:1902010,GO:1903432,GO:1904262,GO:1904262,GO:1904262,GO:1904263,GO:1904504,GO:1990253,GO:1990253,GO:1990253,GO:1990316

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SESN2 hsa:83667 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
SESN2 hsa:83667 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
SESN2 hsa:83667 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SESN2 TSC1 14651849 15509864 15980064 16054095 16054096 17244528 18692468 19037093 19197243 19339977 20484410 26192618 interaction type N/A ACSN
SESN2 TSC2 14651849 15509864 15980064 16054095 16054096 17244528 18692468 19037093 19197243 19339977 20484410 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 SESN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SESN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SESN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SESN2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SESN2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SESN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SESN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SESN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SESN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SESN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SESN2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 SESN2 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000237AF9 SESN2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE SESN2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC864 SESN2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000001EB3 SESN2 20371350 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000183BED SESN2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 SESN2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 SESN2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002DD349 SESN2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 SESN2 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A SESN2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C36BD SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001FA076 SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000472A9B SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA SESN2 22473208 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SESN2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 SESN2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SESN2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SESN2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SESN2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002F74F1 SESN2 20371350 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000458AD2 SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075D15B SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000048BA36 SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000057FDB8 SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD SESN2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000FC8EB SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 SESN2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075A608 SESN2 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SESN2 PRDX6 25361965 interaction type N/A PTMCode2
PRDX6 SESN2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VCP SESN2 25348397 N/A physical interaction ComPPI
KEAP1 SESN2 23274085 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBX1 SESN2 23274085 24234451 25348397 29294217 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 SESN2 14525934 15105503 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SQSTM1 SESN2 23274085 24234451 25040165 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MDM2 SESN2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EGFR SESN2 25348397 N/A physical interaction ComPPI
SEC13 SESN2 25348397 N/A physical interaction ComPPI
RB1CC1 SESN2 24234451 25040165 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 SESN2 24234451 25040165 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
WDR5 SESN2 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
SESN2 ATG13 24234451 25040165 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SESN2 WDR59 24234451 25263562 25348397 28199315 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SESN2 DHX57 25348397 N/A physical interaction ComPPI
SESN2 WDR24 24234451 25263562 25348397 26449471 26586190 28199315 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SESN2 MIOS 24234451 25263562 25348397 26586190 28199315 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SESN2 SZT2 24234451 25348397 28199315 association anti bait coimmunoprecipitation ComPPI,IntAct
SESN2 NPRL2 24234451 25348397 28199315 association anti bait coimmunoprecipitation ComPPI,IntAct
SESN2 NPRL3 24234451 25263562 25348397 28199315 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SESN2 SESN2 24234451 26586190 association anti tag coimmunoprecipitation IntAct

Visualization










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