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GENE：SMCR8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMCR8
FullNmae SMCR8-C9orf72 complex subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17921
EnsembleID ENSG00000176994
Uniprot Q8TEV9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMCR8 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMCR8 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SMCR8 GO:0000785,GO:0004860,GO:0005085,GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005737,GO:0006469,GO:0006914,GO:0010506,GO:0010506,GO:0010629,GO:0016242,GO:0019901,GO:0032008,GO:0032045,GO:0032045,GO:0032045,GO:0042995,GO:0043547,GO:0045920,GO:0050777,GO:0098793,GO:0098794,GO:1901098,GO:1902902,GO:1903432,GO:1990316

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMCR8 hsa:140775 path:hsa04140 Autophagy - animal - Homo sapiens (human)
SMCR8 hsa:140775 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
SMCR8 hsa:140775 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 SMCR8 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A SMCR8 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF SMCR8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SMCR8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB SMCR8 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00001C770D SMCR8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000031E12 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000A07C1 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000000B1C9 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000122ED0 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000029979D SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000237CBD SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000821E0 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000017DBB8 SMCR8 21572407 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000052E1A6 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000058BB84 SMCR8 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075D1FC SMCR8 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000032EF64 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000195F5B SMCR8 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 SMCR8 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 SMCR8 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 SMCR8 21572407 23446348 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000759EB8 SMCR8 21572407 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000412AC7 SMCR8 21572407 24398324 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001DE669 SMCR8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F SMCR8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 SMCR8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000018D2BE SMCR8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D SMCR8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C36BD SMCR8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001FA076 SMCR8 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000DD591 SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042935A SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC SMCR8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 SMCR8 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 SMCR8 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC SMCR8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001DABC0 SMCR8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00005030C1 SMCR8 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F SMCR8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075AB0E SMCR8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000759B6A SMCR8 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005CC20C SMCR8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00005CCD18 SMCR8 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CF056 SMCR8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075C3F6 SMCR8 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TBK1 SMCR8 22135298 phosphorylation N/A PhosphoSite
ULK1 SMCR8 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
ZNRD2 SMCR8 25348397 N/A physical interaction ComPPI
CRYAB SMCR8 25348397 N/A physical interaction ComPPI
IMPDH2 SMCR8 25348397 N/A physical interaction ComPPI
TOMM22 SMCR8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDC16 SMCR8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 SMCR8 25348397 N/A physical interaction ComPPI
CANX SMCR8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MMS19 SMCR8 25348397 N/A physical interaction ComPPI
RAB9A SMCR8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RB1CC1 SMCR8 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOMM20 SMCR8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TGOLN2 SMCR8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLGRKT SMCR8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 SMCR8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FANCA SMCR8 25348397 N/A physical interaction ComPPI
SMCR8 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SMCR8 IMPDH1 25348397 N/A physical interaction ComPPI
SMCR8 C9ORF72 24234451 25348397 27107012 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
SMCR8 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SMCR8 ULK1 27898060 28195531 inhibition N/A OmniPath

Visualization










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