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GENE：SMG1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMG1
FullNmae SMG1 nonsense mediated mRNA decay associated PI3K related kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30045
EnsembleID ENSG00000157106
Uniprot Q96Q15

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMG1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMG1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SMG1 GO:0000184,GO:0000184,GO:0000184,GO:0000184,GO:0003723,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004697,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006406,GO:0006468,GO:0006974,GO:0018105,GO:0018105,GO:0032204,GO:0033391,GO:0042162,GO:0046777,GO:0046854,GO:0046872,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMG1 hsa:23049 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TELO2 SMG1 18160036 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 UPF1 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 SMG9 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 SMG8 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 EIF4A3 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 MAGOH 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 ETF1 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 RPS16 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 UPF2 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMG1 RPL11 19417104 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SMG1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 SMG1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SMG1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 SMG1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SMG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SMG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SMG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SMG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SMG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SMG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 SMG1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D SMG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 SMG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 SMG1 22473208 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00000CF1D2 SMG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000039E1E1 SMG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B SMG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA SMG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 SMG1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000006FDD4 SMG1 20371350 21572407 22473208 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023133F SMG1 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000098B3B SMG1 21572407 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001E0AEA SMG1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 SMG1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000192A75 SMG1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001EB3 SMG1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000060AABB SMG1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000195F5B SMG1 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D814 SMG1 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 SMG1 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 SMG1 21572407 23592263 23824327 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 SMG1 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000043D2C1 SMG1 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004BC299 SMG1 21572407 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001D69F6 SMG1 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB SMG1 21572407 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000254A6 SMG1 21572407 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00005606AA SMG1 21572407 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD02D SMG1 20371350 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D SMG1 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 SMG1 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 SMG1 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 SMG1 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 SMG1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000544FF1 SMG1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001B12A4 SMG1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 SMG1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 SMG1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC4BD SMG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 SMG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000024CEE0 SMG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B SMG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C SMG1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A SMG1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 SMG1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000081D1E SMG1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001310DE SMG1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SMG1 UPF1 22135298 phosphorylation N/A PhosphoSite
SMG1 TP53 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
LMNA SMG1 19417104 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RBM8A SMG1 16452507 19417104 20371770 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
GAPDH SMG1 19417104 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TUBG1 SMG1 25348397 N/A physical interaction ComPPI
HSP90AA1 SMG1 25348397 N/A physical interaction ComPPI
CDH5 SMG1 10428027 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD9 SMG1 25348397 N/A two hybrid ComPPI
RUVBL1 SMG1 20371770 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
HSP90B1 SMG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PABPC1 SMG1 16452507 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA1 SMG1 25348397 N/A physical interaction ComPPI
CBX4 SMG1 25348397 N/A tandem affinity purification ComPPI
SMG1 UPF1 11331269 11544179 14525934 16452507 18256688 18423202 19417104 20371770 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
SMG1 UPF3A 11544179 14525934 16452507 18256688 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SMG1 UPF2 11544179 14525934 16452507 18256688 19417104 20371770 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
SMG1 SMG5 14525934 14636577 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMG1 TTI1 20371770 20810650 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SMG1 TELO2 18160036 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
SMG1 ELAVL1 25348397 N/A physical interaction ComPPI
SMG1 SMG8 19417104 20371770 20817927 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction ComPPI,IntAct
SMG1 SMG9 19417104 20371770 20817927 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction ComPPI,IntAct
SMG1 UPF3B 16452507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMG1 NCBP2 16452507 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMG1 SMG7 16452507 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMG1 MAGOH 16452507 19417104 20371770 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SMG1 GSPT2 16452507 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMG1 GSPT1 25348397 N/A physical interaction ComPPI
SMG1 EEF2 20371770 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SMG1 HSP90AA2P 25348397 N/A physical interaction ComPPI
SMG1 HSPA4 25348397 N/A physical interaction ComPPI
SMG1 RUVBL2 20371770 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SMG1 POLR2E 20371770 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
SMG1 TUBA1A 25348397 N/A physical interaction ComPPI
SMG1 HAUS2 25348397 N/A physical interaction ComPPI
SMG1 HTR6 25348397 N/A physical interaction ComPPI
SMG1 EGFR 25348397 N/A physical interaction ComPPI
SMG1 EIF4A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SMG1 ETF1 16452507 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SMG1 SYNCRIP 19417104 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SMG1 SNAPIN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
PRKCI SMG1 14525934 25348397 8524286 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
EIF4A3 SMG1 16452507 19417104 20371770 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MKI67 SMG1 24234451 26949251 association anti tag coimmunoprecipitation IntAct
SMG1 TP53 15175154 18332866 27898060 stimulant N/A OmniPath
SMG1 UPF1 11331269 11544179 15175154 16452507 18256688 18423202 19417104 20371770 21965535 23275559 23356578 23826386 24115769 25775514 27898060 stimulant N/A OmniPath

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