GENE：TREM2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TREM2 |
| FullNmae | triggering receptor expressed on myeloid cells 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17761 |
| EnsembleID | ENSG00000095970 |
| Uniprot | Q9NZC2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TREM2 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| TREM2 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| TREM2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TREM2 | GO:0001530,GO:0001540,GO:0001774,GO:0001786,GO:0001934,GO:0002282,GO:0002588,GO:0002862,GO:0002931,GO:0004888,GO:0004888,GO:0005515,GO:0005543,GO:0005576,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006910,GO:0006911,GO:0006959,GO:0007613,GO:0007613,GO:0008035,GO:0008289,GO:0008429,GO:0009986,GO:0010468,GO:0010507,GO:0010628,GO:0010628,GO:0010822,GO:0010875,GO:0010887,GO:0010891,GO:0010983,GO:0016020,GO:0019209,GO:0019216,GO:0030169,GO:0030316,GO:0032006,GO:0032008,GO:0032497,GO:0032499,GO:0032675,GO:0032691,GO:0032720,GO:0032733,GO:0033674,GO:0034136,GO:0034144,GO:0034151,GO:0034185,GO:0034186,GO:0034189,GO:0034241,GO:0034351,GO:0035176,GO:0038023,GO:0038023,GO:0038160,GO:0042834,GO:0043124,GO:0043277,GO:0044853,GO:0044877,GO:0045088,GO:0045672,GO:0045728,GO:0045960,GO:0048143,GO:0048678,GO:0048678,GO:0050714,GO:0050730,GO:0050730,GO:0050731,GO:0050766,GO:0050766,GO:0050829,GO:0050850,GO:0050850,GO:0050866,GO:0050921,GO:0051897,GO:0051898,GO:0055088,GO:0060075,GO:0060100,GO:0060100,GO:0060100,GO:0061518,GO:0061889,GO:0070269,GO:0070345,GO:0070374,GO:0070374,GO:0070374,GO:0070392,GO:0070891,GO:0071223,GO:0071224,GO:0071333,GO:0071396,GO:0071456,GO:0071640,GO:0071813,GO:0097028,GO:0097062,GO:0097110,GO:0098657,GO:0110089,GO:0120035,GO:0120035,GO:0120035,GO:0120146,GO:0140052,GO:0150062,GO:0150079,GO:0150079,GO:0150094,GO:0150094,GO:1900015,GO:1900016,GO:1900223,GO:1900223,GO:1900226,GO:1900226,GO:1901076,GO:1901224,GO:1901800,GO:1901980,GO:1902227,GO:1902531,GO:1903078,GO:1903082,GO:1903376,GO:1903753,GO:1903980,GO:1903980,GO:1903980,GO:1904093,GO:1904141,GO:1904141,GO:1904646,GO:1904951,GO:1905291,GO:1905581,GO:1905805,GO:1905808,GO:1905907,GO:1990782,GO:2000350,GO:2001171 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| TREM2 | hsa:54209 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TYROBP | TREM2 | 11602640 12080485 14525934 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct,OmniPath |
| PSEN1 | TREM2 | 24234451 29611543 | colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,confocal microscopy | IntAct |
| SEMA6D | TREM2 | 16715077 27898060 | N/A | N/A | OmniPath |