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GENE：TRIM5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TRIM5
FullNmae tripartite motif containing 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16276
EnsembleID ENSG00000132256
Uniprot Q9C035

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TRIM5 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TRIM5 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TRIM5 GO:0000209,GO:0000932,GO:0002218,GO:0003713,GO:0004842,GO:0005515,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006914,GO:0008270,GO:0010508,GO:0019901,GO:0019901,GO:0030674,GO:0031664,GO:0032880,GO:0032880,GO:0038187,GO:0042802,GO:0042803,GO:0042803,GO:0043123,GO:0043123,GO:0043123,GO:0043410,GO:0044790,GO:0045087,GO:0045087,GO:0045893,GO:0046596,GO:0046597,GO:0051091,GO:0051092,GO:0051092,GO:0051607,GO:0061630,GO:0070534,GO:1990462

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TRIM5 hsa:85363 path:hsa03250 Viral life cycle - HIV-1 - Homo sapiens (human)
TRIM5 hsa:85363 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
UBE2W TRIM5 23180781 26101372 ubiquitination reaction ubiquitinase assay InnateDB
UBE2N TRIM5 23180781 26101372 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TRIM5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TRIM5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TRIM5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TRIM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TRIM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TRIM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TRIM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TRIM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TRIM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TRIM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 TRIM5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000D5659 TRIM5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000759F6E TRIM5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 TRIM5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000FFE5F TRIM5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB TRIM5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D TRIM5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000358C16 TRIM5 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ZWINT TRIM5 25361965 interaction type N/A PTMCode2
TRIM5 ZWINT 25361965 interaction type N/A PTMCode2
BTBD1 TRIM5 25361965 interaction type N/A PTMCode2
TRIM5 BTBD1 25361965 interaction type N/A PTMCode2
BTBD2 TRIM5 25361965 interaction type N/A PTMCode2
TRIM5 BTBD2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 TRIM5 25348397 N/A physical interaction ComPPI
TRIM21 TRIM5 25348397 N/A physical interaction ComPPI
TNFAIP3 TRIM5 25348397 N/A physical interaction ComPPI
PSMD7 TRIM5 25348397 N/A physical interaction ComPPI
PCBD1 TRIM5 25348397 N/A physical interaction ComPPI
TRIM32 TRIM5 22493164 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MKRN3 TRIM5 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D1 TRIM5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SNAI1 TRIM5 24234451 25203322 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TAB3 TRIM5 25348397 N/A physical interaction ComPPI
UBE2D4 TRIM5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SUMO1 TRIM5 21490953 25348397 25880753 27898060 N/A physical interaction ComPPI,OmniPath
PIAS1 TRIM5 25348397 N/A physical interaction ComPPI
UBE2D2 TRIM5 12878161 18312418 19549727 24234451 25348397 27898060 physical association physical interaction,two hybrid array,enzymatic study ComPPI,IntAct,OmniPath
UBB TRIM5 25348397 N/A physical interaction ComPPI
UBC TRIM5 25348397 N/A physical interaction ComPPI
UBE2N TRIM5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CFTR TRIM5 25348397 N/A physical interaction ComPPI
PRKCG TRIM5 25348397 N/A physical interaction ComPPI
SQSTM1 TRIM5 25348397 N/A physical interaction ComPPI
EWSR1 TRIM5 25348397 N/A physical interaction ComPPI
MAP3K11 TRIM5 25348397 N/A physical interaction ComPPI
XPO1 TRIM5 25348397 N/A physical interaction ComPPI
MNAT1 TRIM5 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSMC5 TRIM5 25348397 N/A physical interaction ComPPI
PSMC4 TRIM5 25348397 N/A physical interaction ComPPI
UBE2K TRIM5 25348397 N/A physical interaction ComPPI
LGALS8 TRIM5 25348397 N/A physical interaction ComPPI
MAP3K7 TRIM5 25348397 N/A physical interaction ComPPI
TAB2 TRIM5 25348397 N/A physical interaction ComPPI
UBE2D3 TRIM5 18799573 19549727 24234451 25348397 26212332 27898060 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct,OmniPath
UBE2H TRIM5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2V1 TRIM5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2V2 TRIM5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ZWINT TRIM5 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
TRIM5 TRIM6 11331580 16775307 16828831 25348397 27898060 N/A two hybrid,physical interaction ComPPI,OmniPath
TRIM5 BTBD1 25348397 N/A in vitro ComPPI
TRIM5 BTBD2 25348397 N/A fluorescence microscopy,in vitro ComPPI
TRIM5 UBE2U 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM5 PSMC2 22078707 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TRIM5 TRIM34 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM5 TRIM35 25348397 N/A physical interaction ComPPI
TRIM5 IKBKG 25348397 N/A physical interaction ComPPI
TRIM5 MAP3K1 25348397 N/A physical interaction ComPPI
TRIM5 USP2 25348397 N/A physical interaction ComPPI
TRIM5 USP5 25348397 N/A physical interaction ComPPI
TRIM5 USP15 25348397 N/A physical interaction ComPPI
TRIM5 USP21 25348397 N/A physical interaction ComPPI
TRIM5 USP39 25348397 N/A physical interaction ComPPI
TRIM5 OTUB2 25348397 N/A physical interaction ComPPI
TRIM5 OTUD6A 25348397 N/A physical interaction ComPPI
TRIM5 CUEDC1 25348397 N/A physical interaction ComPPI
TRIM5 YARS1 25348397 N/A physical interaction ComPPI
TRIM5 CREB1 25348397 N/A physical interaction ComPPI
LZTR1 TRIM5 25348397 N/A physical interaction ComPPI
TRIM5 TRIM5 22493164 22829933 24234451 physical association anti tag coimmunoprecipitation,two hybrid,two hybrid array IntAct
HSPA4 TRIM5 20053985 20810659 27898060 N/A N/A OmniPath

Visualization










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