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GENE：ZMPSTE24

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ZMPSTE24
FullNmae zinc metallopeptidase STE24
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12877
EnsembleID ENSG00000084073
Uniprot O75844

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ZMPSTE24 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ZMPSTE24 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ZMPSTE24 GO:0001889,GO:0001942,GO:0003007,GO:0003229,GO:0003231,GO:0003417,GO:0003690,GO:0004222,GO:0005515,GO:0005637,GO:0005789,GO:0006281,GO:0006508,GO:0006925,GO:0006998,GO:0007628,GO:0008235,GO:0008340,GO:0008360,GO:0010506,GO:0010906,GO:0016020,GO:0019216,GO:0030282,GO:0030327,GO:0030500,GO:0031901,GO:0031902,GO:0032006,GO:0032350,GO:0032991,GO:0035264,GO:0040014,GO:0043007,GO:0043516,GO:0044029,GO:0044030,GO:0044255,GO:0046872,GO:0048145,GO:0048538,GO:0050688,GO:0050905,GO:0055013,GO:0060307,GO:0060993,GO:0061337,GO:0061762,GO:0070062,GO:0070302,GO:0071480,GO:0071586,GO:0072423,GO:1903463,GO:1903799,GO:1990036,GO:2000730,GO:2000772

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ZMPSTE24 hsa:10269 path:hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ZMPSTE24 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ZMPSTE24 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ZMPSTE24 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ZMPSTE24 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ZMPSTE24 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ZMPSTE24 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ZMPSTE24 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ZMPSTE24 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ZMPSTE24 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC ZMPSTE24 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 ZMPSTE24 17942906 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000003E1A9 ZMPSTE24 24101728 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000040EC3B ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000065D58 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002152A8 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000005CF5F ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001DE669 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000021D08 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000496C56 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000319E1 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000037B2E0 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C02E4 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000118224 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004283FE ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AEA5 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075B13F ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000039A25B ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000008AA34 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000080D0A ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 ZMPSTE24 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ZMPSTE24 DNAJA1 25361965 interaction type N/A PTMCode2
DNAJA1 ZMPSTE24 25361965 interaction type N/A PTMCode2
MME ZMPSTE24 25361965 interaction type N/A PTMCode2
ZMPSTE24 MME 25361965 interaction type N/A PTMCode2
ICMT ZMPSTE24 25361965 interaction type N/A PTMCode2
ZMPSTE24 ICMT 25361965 interaction type N/A PTMCode2
RCE1 ZMPSTE24 25361965 interaction type N/A PTMCode2
ZMPSTE24 RCE1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BAG3 ZMPSTE24 25348397 N/A physical interaction ComPPI
LMNA ZMPSTE24 25348397 N/A x-ray crystallography,physical interaction,protease assay,protein cleavage ComPPI
MED21 ZMPSTE24 25348397 N/A physical interaction ComPPI
MRPL40 ZMPSTE24 25348397 N/A physical interaction ComPPI
DUSP23 ZMPSTE24 25348397 N/A physical interaction ComPPI
RAB10 ZMPSTE24 25348397 N/A physical interaction ComPPI
PTPN1 ZMPSTE24 25348397 N/A physical interaction ComPPI
VDAC1 ZMPSTE24 25348397 N/A physical interaction ComPPI
SYNJ2BP ZMPSTE24 25348397 N/A physical interaction ComPPI
TNFRSF17 ZMPSTE24 25348397 N/A physical interaction ComPPI
CLTC ZMPSTE24 25348397 N/A physical interaction ComPPI
CYP1A1 ZMPSTE24 25348397 N/A physical interaction ComPPI
GTF2E2 ZMPSTE24 25348397 N/A physical interaction ComPPI
FDPS ZMPSTE24 25348397 N/A physical interaction ComPPI
MME ZMPSTE24 17342744 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPUL1 ZMPSTE24 25348397 N/A physical interaction ComPPI
HNRNPF ZMPSTE24 25348397 N/A physical interaction ComPPI
PMF1 ZMPSTE24 25348397 N/A physical interaction ComPPI
ELAVL1 ZMPSTE24 25348397 N/A physical interaction ComPPI
DEFB4A ZMPSTE24 25348397 N/A physical interaction ComPPI
S100A10 ZMPSTE24 25348397 N/A physical interaction ComPPI
RAB5C ZMPSTE24 25348397 N/A physical interaction ComPPI
CD55 ZMPSTE24 25348397 N/A physical interaction ComPPI
TMEM43 ZMPSTE24 25348397 N/A physical interaction ComPPI
MGST3 ZMPSTE24 25348397 N/A physical interaction ComPPI
VAC14 ZMPSTE24 25348397 N/A physical interaction ComPPI
GALNT2 ZMPSTE24 25348397 N/A physical interaction ComPPI
DDOST ZMPSTE24 25348397 N/A physical interaction ComPPI
MRPS5 ZMPSTE24 25348397 N/A physical interaction ComPPI
ATP6V1H ZMPSTE24 25348397 N/A physical interaction ComPPI
FTSJ1 ZMPSTE24 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RNF26 ZMPSTE24 25348397 N/A physical interaction ComPPI
ZMPSTE24 NDUFB7 25348397 N/A physical interaction ComPPI
ZMPSTE24 KIAA2013 25348397 N/A physical interaction ComPPI
ZMPSTE24 TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ZMPSTE24 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ZMPSTE24 SLC18A1 25348397 N/A physical interaction ComPPI
ZMPSTE24 GDPD5 25348397 N/A physical interaction ComPPI
ZMPSTE24 GPR21 25348397 N/A physical interaction ComPPI
ZMPSTE24 SLC17A2 25348397 N/A physical interaction ComPPI
ZMPSTE24 TMPRSS12 25348397 N/A physical interaction ComPPI
ZMPSTE24 SLC2A5 25348397 N/A physical interaction ComPPI
ZMPSTE24 GJB7 25348397 N/A physical interaction ComPPI
ZMPSTE24 H1-5 24234451 30021884 physical association cross-linking study IntAct
ZMPSTE24 SPATA48 24234451 30021884 physical association cross-linking study IntAct
CDX1 ZMPSTE24 24234451 30021884 physical association cross-linking study IntAct

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