Gene Information gene info

GENE:BMPR2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BMPR2
FullNmae bone morphogenetic protein receptor type 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1078
EnsembleID ENSG00000204217
Uniprot Q13873

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BMPR2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMPR2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMPR2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BMPR2 GO:0001568,GO:0001649,GO:0001707,GO:0001893,GO:0001935,GO:0001946,GO:0001974,GO:0002063,GO:0003085,GO:0003151,GO:0003176,GO:0003177,GO:0003183,GO:0003186,GO:0003197,GO:0003252,GO:0005024,GO:0005515,GO:0005524,GO:0005615,GO:0005654,GO:0005886,GO:0005886,GO:0005886,GO:0005901,GO:0005905,GO:0005912,GO:0006468,GO:0007178,GO:0009267,GO:0009925,GO:0009952,GO:0009986,GO:0010628,GO:0010634,GO:0014069,GO:0014916,GO:0014916,GO:0016310,GO:0016324,GO:0016362,GO:0019838,GO:0030166,GO:0030308,GO:0030424,GO:0030425,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0032924,GO:0036122,GO:0042127,GO:0043025,GO:0043235,GO:0045296,GO:0045669,GO:0045778,GO:0045906,GO:0045944,GO:0045944,GO:0046872,GO:0048286,GO:0048662,GO:0048842,GO:0051148,GO:0060173,GO:0060350,GO:0060391,GO:0060391,GO:0060412,GO:0060413,GO:0060426,GO:0060836,GO:0060840,GO:0060841,GO:0061036,GO:0061298,GO:0071363,GO:0071773,GO:0072577,GO:0098821,GO:1902731,GO:1905314,GO:1990782,GO:2000279

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BMPR2 hsa:659 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
BMPR2 hsa:659 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
BMPR2 hsa:659 path:hsa04360 Axon guidance - Homo sapiens (human)
BMPR2 hsa:659 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
BMPR2 hsa:659 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
BMPR2 hsa:659 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
BMPR2 hsa:659 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRIB3 BMPR2 17576816 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRC BMPR2 16002577 17576816 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
BMPR2 BMP7 18342887 23180781 physical association surface plasmon resonance,solid phase assay InnateDB
BMP2 BMPR2 16446785 17295905 18342887 23180781 23331499 stimulation,physical association surface plasmon resonance InnateDB,SignaLink,SignaLink
GDF5 BMPR2 16446785 18342887 23180781 23331499 9525338 stimulation,physical association surface plasmon resonance InnateDB,SignaLink
CD44 BMPR2 20206131 23180781 physical association anti tag coimmunoprecipitation InnateDB
BMPR2 BMPR2 18756288 26467481 7791754 phosphorylation reaction,bind,up-regulates N/A Signor
BMPR2 ACVR1 16446785 21071413 23331499 7791754 stimulation N/A SignaLink,SignaLink
BMPR2 BMPR1B 10712517 16446785 21071413 23331499 7791754 stimulation N/A SignaLink,SignaLink
BMP7 BMPR2 16446785 23331499 stimulation N/A SignaLink,SignaLink
BMP6 BMPR2 10504300 16446785 21071413 23331499 stimulation N/A SignaLink,SignaLink
GDF6 BMPR2 16446785 18988627 23331499 9525338 stimulation N/A SignaLink,SignaLink
BMP4 BMPR2 16446785 21071413 23331499 7644468 stimulation N/A SignaLink,SignaLink
PRMT1 BMPR2 23747011 interaction type,stimulation N/A SignaLink
BMP15 BMPR2 16446785 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
FRS3 BMPR2 20005715 interaction type N/A PSP
LSP1 BMPR2 20005715 interaction type N/A PSP
FRS3 BMPR2 15188402 15188402 18988627 20005715 20005715 21071413 N/A N/A SignaLink
LSP1 BMPR2 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR BMPR2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BMPR2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 BMPR2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 BMPR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001A405B BMPR2 22684006 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002075FA BMPR2 19390056 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000018C928 BMPR2 23352489 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000006FDD4 BMPR2 19390056 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000042E1F BMPR2 19390056 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D BMPR2 18829576 19578724 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000027080C BMPR2 22988237 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000042E1F BMPR2 18927107 19390056 22473208 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000009262D BMPR2 18591254 18829576 19578724 22227207 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 BMPR2 19390056 22473208 24145352 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002075FA BMPR2 19390056 22473208 24145352 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00001A405B BMPR2 19536157 22684006 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000027080C BMPR2 22988237 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000315338 BMPR2 22942087 23418453 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS000018C928 BMPR2 22473208 23352489 25416803 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 BMPR2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 BMPR2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 BMPR2 20371350 22473208 23622248 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip,clash TarBase
URS000003ABC4 BMPR2 19088304 20371350 25416803 mrna cleavage,inhibition array technology,nucleotide sequence identification TarBase
URS00000600E6 BMPR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 BMPR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 BMPR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 BMPR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 BMPR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 BMPR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F BMPR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 BMPR2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 BMPR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000001C659 BMPR2 24802670 25416803 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000020579D BMPR2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 BMPR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000011166D BMPR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD BMPR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000209905 BMPR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000302909 BMPR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 BMPR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 BMPR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 BMPR2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE BMPR2 25416803 25543998 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
BMPR1B BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 BMPR1B 25361965 interaction type N/A PTMCode2
CTBP1 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 CTBP1 25361965 interaction type N/A PTMCode2
BMP4 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 BMP4 25361965 interaction type N/A PTMCode2
GDF9 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 GDF9 25361965 interaction type N/A PTMCode2
TOPBP1 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 TOPBP1 25361965 interaction type N/A PTMCode2
ACTR8 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 ACTR8 25361965 interaction type N/A PTMCode2
BMPR1A BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 BMPR1A 25361965 interaction type N/A PTMCode2
GDF5 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 GDF5 25361965 interaction type N/A PTMCode2
RABGGTA BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 RABGGTA 25361965 interaction type N/A PTMCode2
ACVR1 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 ACVR1 25361965 interaction type N/A PTMCode2
BMPR2 BMP2 25361965 interaction type N/A PTMCode2
BMP2 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 BMP7 25361965 interaction type N/A PTMCode2
BMP7 BMPR2 25361965 interaction type N/A PTMCode2
DYNLT1 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 DYNLT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MOS BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FRS3 BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPP1CC BMPR2 25348397 N/A physical interaction ComPPI
CRYAB BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TRIB3 BMPR2 25348397 N/A physical interaction ComPPI
BMP7 BMPR2 14525934 25348397 7791754 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
TUBB BMPR2 25348397 N/A in vitro ComPPI
XIAP BMPR2 25348397 N/A physical interaction ComPPI
MAPK8 BMPR2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD7 BMPR2 25348397 N/A physical interaction ComPPI
FHL2 BMPR2 19265191 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CTBP1 BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TRPC1 BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKG1 BMPR2 19424179 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
BMP4 BMPR2 14525934 25348397 7644468 8702914 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDH1 BMPR2 25348397 N/A physical interaction ComPPI
CAV1 BMPR2 25348397 N/A physical interaction ComPPI
PRKCB BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NBEA BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HNRNPL BMPR2 25348397 N/A physical interaction ComPPI
C4BPA BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 MAP3K8 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 LMX1A 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 GDF5 19229295 24234451 25348397 N/A surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,IntAct
BMPR2 BMPR1A 10712517 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BMPR2 LIMK1 12963706 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
BMPR2 RABGGTA 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 GDF9 12135884 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BMPR2 TUBB4A 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 BMPR1B 10712517 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BMPR2 MERTK 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 HNRNPR 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 PMPCA 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 CCDC89 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 ARSA 25348397 N/A in vitro ComPPI
BMPR2 ACTR8 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 NOP56 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 TWF1 25348397 N/A in vitro ComPPI
BMPR2 GDF6 14525934 25348397 9525338 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BMPR2 LSM10 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 PDZRN3 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 DYNLT1 14525934 14583445 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
BMPR2 BMP2 10880444 14525934 24234451 25348397 25938661 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
BMPR2 BMP6 11401330 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BMPR2 CES1 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 LSP1 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 CES3 25348397 N/A physical interaction ComPPI
BMPR2 GCGR 25348397 N/A physical interaction ComPPI
BMPR2 TGFBR1 25348397 N/A physical interaction ComPPI
BMPR2 ACVR1B 25348397 N/A physical interaction ComPPI
BMPR2 TSR1 25348397 N/A physical interaction ComPPI
BMPR2 ACVR1 25348397 N/A physical interaction ComPPI
BMPR2 FST 25348397 N/A physical interaction ComPPI
BMPR2 SMAD6 25348397 N/A physical interaction ComPPI
BMPR2 GDF2 25348397 N/A physical interaction ComPPI
BMPR2 BMP10 25348397 N/A physical interaction ComPPI
BMPR2 PYCARD 24234451 24407287 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BMPR2 LRRIQ1 25348397 N/A physical interaction ComPPI
BMPR2 RUSF1 25348397 N/A physical interaction ComPPI
BMPR2 MRAP2 25348397 N/A physical interaction ComPPI
BMPR2 CD83 25348397 N/A physical interaction ComPPI
BMPR2 ARMH4 25348397 N/A physical interaction ComPPI
BMPR2 RNF11 25348397 N/A physical interaction ComPPI
SULT1E1 BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSCB BMPR2 24234451 24606901 25348397 physical association two hybrid ComPPI,IntAct
BMPR2 TUBB2A 14525934 15188402 N/A experimental interaction detection HPRD
FOXL1 BMPR2 14525934 15188402 N/A experimental interaction detection HPRD
BMPR2 TOPBP1 14525934 15188402 N/A experimental interaction detection HPRD
BMPR2 BMPR2 10712517 14525934 N/A experimental interaction detection HPRD
BMPR2 SRC 16002577 17576816 27898060 N/A N/A OmniPath
BMP4 BMPR2 12045205 27898060 7644468 7673243 8006002 8702914 stimulant N/A OmniPath
CSNK2A1 BMPR2 16155937 27898060 N/A N/A OmniPath
PPP2CA BMPR2 19339557 27898060 N/A N/A OmniPath
BMPR1A BMPR2 10712517 18756288 27898060 7791754 stimulant N/A OmniPath
BMPR2 BMPR1A 10712517 18756288 27898060 7791754 stimulant N/A OmniPath
BMPR2 BMPR1B 10712517 18756288 27898060 7791754 stimulant N/A OmniPath
BMPR2 ACVR1 27898060 7791754 7890683 stimulant N/A OmniPath
BMP2 BMPR2 10712517 10880444 17295905 18342887 25938661 27898060 7791754 stimulant N/A OmniPath
SMURF2 BMPR2 22298955 27898060 inhibition N/A OmniPath
SMURF1 BMPR2 17317136 22298955 27898060 inhibition N/A OmniPath
GDF6 BMPR2 16049014 27898060 9525338 stimulant N/A OmniPath
NOG BMPR2 22298955 27898060 inhibition N/A OmniPath
BMP15 BMPR2 12419820 16446785 27898060 stimulant N/A OmniPath
GDF2 BMPR2 15851468 27898060 N/A N/A OmniPath
CTDNEP1 BMPR2 17141153 27898060 inhibition N/A OmniPath
BMP7 BMPR2 18342887 27898060 7644468 7791754 stimulant N/A OmniPath
PPP2CB BMPR2 19339557 27898060 N/A N/A OmniPath

Visualization