GENE：C5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | C5 |
| FullNmae | complement C5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1331 |
| EnsembleID | ENSG00000106804 |
| Uniprot | P01031 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| C5 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| C5 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| C5 | GO:0004866,GO:0005102,GO:0005515,GO:0005576,GO:0005579,GO:0005615,GO:0006935,GO:0006954,GO:0006957,GO:0006958,GO:0007166,GO:0007186,GO:0008009,GO:0010575,GO:0010760,GO:0031640,GO:0032722,GO:0060326,GO:0070062 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| C5 | hsa:727 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa05133 | Pertussis - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| C5 | hsa:727 | path:hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMARCA4 | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | C5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| C5 | C3 | 25361965 | interaction type | N/A | PTMCode2 |
| C3 | C5 | 25361965 | interaction type | N/A | PTMCode2 |
| C5 | C6 | 25361965 | interaction type | N/A | PTMCode2 |
| C6 | C5 | 25361965 | interaction type | N/A | PTMCode2 |
| C5 | C7 | 25361965 | interaction type | N/A | PTMCode2 |
| C7 | C5 | 25361965 | interaction type | N/A | PTMCode2 |
| C5 | C5AR1 | 25361965 | interaction type | N/A | PTMCode2 |
| C5AR1 | C5 | 25361965 | interaction type | N/A | PTMCode2 |
| C5 | C8B | 25361965 | interaction type | N/A | PTMCode2 |
| C8B | C5 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LMNA | C5 | 25348397 | N/A | physical interaction | ComPPI |
| C5 | C5AR1 | 14525934 25348397 9553099 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| C5 | C3 | 11367533 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| C5 | C8B | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| C5 | C6 | 1387399 14525934 25348397 2808363 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| C5 | C7 | 1387399 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| C5 | CPN1 | 11939578 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| C5 | CPB2 | 25348397 | N/A | physical interaction | ComPPI |
| C5 | CREB3L1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| C5 | PGRMC2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| C5 | MMGT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| C5 | CPLX4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| C5 | POU6F2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| C5 | KEL | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| C5 | C5 | 14525934 3624872 8175701 | N/A | experimental interaction detection | HPRD |
| C2 | C5 | 12878586 14525934 27898060 8175701 | N/A | experimental interaction detection | HPRD,OmniPath |
| C5 | C5AR2 | 11773063 12899627 27898060 | stimulant | N/A | OmniPath |
| C5 | C5AR1 | 10602324 11773063 15661745 1847994 27898060 9553099 | stimulant | N/A | OmniPath |