GENE：COMP
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | COMP |
| FullNmae | cartilage oligomeric matrix protein |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2227 |
| EnsembleID | ENSG00000105664 |
| Uniprot | P49747 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| COMP | apoptosis | 36012514 | Mutations of COMP cause endoplasmic reticulum stress and chondrocyte apoptosis, resulting in rare skeleton diseases. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| COMP | GO:0001501,GO:0002020,GO:0002063,GO:0003417,GO:0005178,GO:0005201,GO:0005509,GO:0005515,GO:0005518,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0006915,GO:0006986,GO:0008201,GO:0009306,GO:0009887,GO:0010468,GO:0014829,GO:0016485,GO:0030199,GO:0030282,GO:0030500,GO:0030509,GO:0031012,GO:0032991,GO:0035264,GO:0035988,GO:0035989,GO:0036122,GO:0043066,GO:0043394,GO:0043395,GO:0043588,GO:0048844,GO:0050881,GO:0051260,GO:0060173,GO:0062023,GO:0062023,GO:0070062,GO:0070527,GO:0090398,GO:0097084,GO:1900047,GO:1902732,GO:1990079 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| COMP | hsa:1311 | path:hsa04145 | Phagosome - Homo sapiens (human) |
| COMP | hsa:1311 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| COMP | hsa:1311 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| COMP | hsa:1311 | path:hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| COMP | hsa:1311 | path:hsa05144 | Malaria - Homo sapiens (human) |
| COMP | hsa:1311 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | COMP | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | COMP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | COMP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | COMP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | COMP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZBTB7A | COMP | 15337766 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | COMP | 11223338 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | COMP | 11223338 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| OTX1 | COMP | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| AQP1 | COMP | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATOX1 | COMP | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NUFIP2 | COMP | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| COL2A1 | COMP | 14525934 25348397 27898060 9685393 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| ECM1 | COMP | 20138147 25348397 27898060 | N/A | anti bait coimmunoprecipitation | ComPPI,OmniPath |
| COMP | FN1 | 12225811 14525934 27898060 | N/A | experimental interaction detection | HPRD,OmniPath |