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GENE：GZMB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GZMB
FullNmae granzyme B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4709
EnsembleID ENSG00000100453
Uniprot P10144

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GZMB pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GZMB pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GZMB mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GZMB apoptosis 38211590 Although not observed in mouse ILC2s, we found that human ILC2s secrete granzyme B (GZMB) and directly lyse tumor cells by inducing pyroptosis and/or apoptosis, which is governed by a DNAM-1-CD112/CD155 interaction that inactivates the negative regulator FOXO1. retulator signature
GZMB apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GZMB GO:0001772,GO:0004252,GO:0004252,GO:0004252,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005737,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0008236,GO:0016020,GO:0017148,GO:0031640,GO:0042267,GO:0042267,GO:0043231,GO:0044194,GO:0051603,GO:0051604,GO:0070269,GO:0070269,GO:0140507,GO:1900740

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GZMB hsa:3002 path:hsa04210 Apoptosis - Homo sapiens (human)
GZMB hsa:3002 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
GZMB hsa:3002 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
GZMB hsa:3002 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
GZMB hsa:3002 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
GZMB hsa:3002 path:hsa05330 Allograft rejection - Homo sapiens (human)
GZMB hsa:3002 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
M6PR GZMB 11081635 20634814 26192618 8432729 interaction type N/A ACSN
GZMB MCL1 10364179 10805722 11062502 11085742 11085743 11287608 11583622 11832478 14499263 15014070 15536084 15607806 15637055 15713684 16106370 18287025 20189481 23180781 24248158 24795729 26192618 8432729 9727492 interaction type,protein cleavage protease assay ACSN,InnateDB
GZMB BID 10364179 10805722 11062502 11085742 11085743 11287608 11583622 11832478 14499263 15536084 15607806 15637055 15713684 16106370 18287025 20189481 24248158 24795729 26192618 8432729 9727492 interaction type N/A ACSN
GZMB BAD 10364179 10805722 11062502 11085742 11085743 11287608 11583622 11832478 14499263 15536084 15607806 15637055 15713684 16106370 18287025 20189481 24248158 24795729 26192618 8432729 9727492 interaction type N/A ACSN
PRKCQ GZMB 10652356 12811837 15214048 15536066 16606694 17544292 17548359 18784374 19201850 19833085 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
DEPTOR GZMB 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MLST8 GZMB 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
MTOR GZMB 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
RPTOR GZMB 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18372248 18492954 19022819 19143636 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 26192618 28216025 interaction type N/A ACSN
TBX21 GZMB 10761931 12055627 12802010 14614857 15084276 16410834 17440449 18768831 26192618 26885856 interaction type N/A ACSN
GZMB CASP7 15569669 15650747 17283187 19103589 23180781 cleavage reaction,protein cleavage protease assay InnateDB
GZMB SERPINB9 11278311 11485349 15494398 16405655 16547231 17116752 23180781 9182575 9774654 physical association anti tag coimmunoprecipitation,comigration in gel electrophoresis,comigration in sds page InnateDB
GZMB HSPA4 12874291 16798735 23180781 protein cleavage,physical association affinity chromatography technology,protease assay InnateDB
GZMB CASP3 11696597 12745270 15569669 16415351 16495481 17179148 17283187 19103589 23180781 8700869 8755496 protein cleavage protease assay InnateDB
GZMB CASP8 15569669 17283187 19103589 23180781 protein cleavage protease assay InnateDB
GZMB CASP10 15569669 23180781 8755496 protein cleavage protease assay InnateDB
BID GZMB 10805722 11696597 12808108 15014070 15569669 16415351 17179148 17283187 19103589 23180781 protein cleavage protease assay InnateDB
GZMB DFFA 17283187 23180781 protein cleavage protease assay InnateDB
GZMB PTGES3 17283187 19103589 23180781 protein cleavage protease assay InnateDB
GZMB CD2AP 17283187 19103589 23180781 protein cleavage protease assay InnateDB
GZMB NOTCH1 16798735 23180781 protein cleavage protease assay InnateDB
GZMB FGFR1 16798735 23180781 protein cleavage protease assay InnateDB
GZMB PARP1 12745270 16798735 23180781 protein cleavage protease assay InnateDB
GZMB XRCC5 23180781 8760815 protein cleavage protease assay InnateDB
GZMB XRCC6 23180781 8760815 protein cleavage protease assay InnateDB
GZMB CASP9 23180781 8900201 protein cleavage protease assay InnateDB
GZMB JUN 23180781 9857074 physical association electrophoretic mobility shift assay InnateDB
GZMB IKZF1 23180781 9857074 physical association electrophoretic mobility shift assay InnateDB
GZMB SSB 16178869 17945310 23180781 protein cleavage protease assay InnateDB
GZMB TUBA1A 16495481 23180781 protein cleavage protease assay InnateDB
GZMB CD247 12208735 23180781 protein cleavage protease assay InnateDB
GZMB VTN 15843372 23180781 protein cleavage protease assay InnateDB
GZMB LAMA5 15843372 23180781 protein cleavage protease assay InnateDB
GZMB CASP1 23180781 8700869 protein cleavage protease assay InnateDB
GZMB UBE4B 11802788 23180781 protein cleavage protease assay InnateDB
GZMB VWF 18577516 23180781 protein cleavage protease assay InnateDB
GZMB NPM1 19103589 23180781 protein cleavage protease assay InnateDB
GZMB SPTAN1 19103589 23180781 protein cleavage protease assay InnateDB
GZMB VIM 19103589 23180781 protein cleavage protease assay InnateDB
GZMB ARHGDIA 19103589 23180781 protein cleavage protease assay InnateDB
GZMB IL33 23180781 25313073 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 GZMB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 GZMB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 GZMB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GZMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GZMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GZMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GZMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 GZMB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPZ GZMB 9857074 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
GZMB SRGN 25361965 interaction type N/A PTMCode2
SRGN GZMB 25361965 interaction type N/A PTMCode2
GZMB CASP7 25361965 interaction type N/A PTMCode2
CASP7 GZMB 25361965 interaction type N/A PTMCode2
GZMB CASP3 25361965 interaction type N/A PTMCode2
CASP3 GZMB 25361965 interaction type N/A PTMCode2
GZMB RAB27A 25361965 interaction type N/A PTMCode2
RAB27A GZMB 25361965 interaction type N/A PTMCode2
GZMB IGF2R 25361965 interaction type N/A PTMCode2
IGF2R GZMB 25361965 interaction type N/A PTMCode2
GZMB GRIA1 25361965 interaction type N/A PTMCode2
GRIA1 GZMB 25361965 interaction type N/A PTMCode2
GZMB DFFA 25361965 interaction type N/A PTMCode2
DFFA GZMB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SRGN GZMB 10228010 11911826 12388539 14525934 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction ComPPI,HPRD,IntAct,OmniPath
LMNA GZMB 25348397 N/A physical interaction ComPPI
PRF1 GZMB 11911826 14525934 24234451 25348397 27898060 8770355 physical association anti bait coimmunoprecipitation,experimental interaction detection ComPPI,HPRD,IntAct,OmniPath
CD2AP GZMB 25348397 N/A physical interaction ComPPI
CASP3 GZMB 14525934 25348397 9233763 9694885 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKDC GZMB 14525934 25348397 9586635 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ELANE GZMB 24234451 25348397 27898060 9404514 physical association x-ray crystallography,x ray scattering ComPPI,IntAct,OmniPath
XRCC5 GZMB 25348397 N/A physical interaction ComPPI
CASP7 GZMB 14525934 25348397 8631895 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CASP8 GZMB 25348397 N/A physical interaction ComPPI
PTGES3 GZMB 25348397 N/A physical interaction ComPPI
XRCC6 GZMB 25348397 N/A physical interaction ComPPI
EEA1 GZMB 21685908 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
TUBA1A GZMB 25348397 N/A physical interaction ComPPI
HSPA4 GZMB 12874291 16798735 25348397 27898060 N/A physical interaction ComPPI,OmniPath
DFFA GZMB 11406587 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SERPINB9 GZMB 14525934 25348397 8910377 N/A experimental interaction detection,physical interaction ComPPI,HPRD
UBE4A GZMB 11802788 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
FN1 GZMB 23228447 24234451 25348397 27898060 protein cleavage protease assay ComPPI,IntAct,OmniPath
GZMB BID 11085743 14525934 25348397 9727491 N/A experimental interaction detection,physical interaction ComPPI,HPRD
GZMB CHRM3 11665980 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
GZMB GZMB 11209755 14525934 N/A experimental interaction detection HPRD
IGF2R GZMB 11081635 14525934 N/A experimental interaction detection HPRD
GZMB LMNB1 11331782 14525934 N/A experimental interaction detection HPRD
GZMB PARP1 14525934 9586635 N/A experimental interaction detection HPRD
GZMB GRIA3 11160179 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
RAB27A GZMB 11266473 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
GZMB XRCC4 12218164 14525934 N/A experimental interaction detection HPRD
GZMB CASP9 1067155 14525934 8900201 9651578 N/A experimental interaction detection HPRD
SSB GZMB 16178869 17945310 27898060 N/A N/A OmniPath
GZMB MNS1 23400704 27898060 N/A N/A OmniPath
GZMB CASP1 27898060 8700869 N/A N/A OmniPath
GZMB HAX1 20388708 27898060 inhibition N/A OmniPath
GZMB FGFR1 16798735 27898060 N/A N/A OmniPath
GZMB IGF2R 11081635 27898060 stimulant N/A OmniPath
GZMB DFFA 11406587 17283187 27898060 inhibition N/A OmniPath
GZMB CASP3 11696597 12745270 15569669 16415351 16495481 17008916 17179148 17283187 19103589 27898060 8700869 8755496 9233763 9694885 stimulant N/A OmniPath
GZMB BID 10805722 11085742 11085743 11696597 12808108 15014070 15569669 16415351 17179148 17283187 19103589 27898060 9727491 stimulant N/A OmniPath
GZMB BAD 11287608 27898060 stimulant N/A OmniPath
GZMB IL33 25313073 27898060 N/A N/A OmniPath
GZMB CASP8 15569669 17283187 19103589 27898060 stimulant N/A OmniPath
GZMB CASP10 15569669 27898060 8755496 stimulant N/A OmniPath
GZMB TUBA4B 16495481 27898060 stimulant N/A OmniPath
GZMB RAB3A 11516400 27898060 stimulant N/A OmniPath

Visualization










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