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GENE：NOS3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NOS3
FullNmae nitric oxide synthase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7876
EnsembleID ENSG00000164867
Uniprot P29474

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NOS3 apoptosis 33747912 NOS3 has been reported to inhibit apoptosis and promote angiogenesis, proliferation, and invasiveness. retulator signature
NOS3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NOS3 GO:0000139,GO:0001525,GO:0001542,GO:0001701,GO:0001974,GO:0002028,GO:0003057,GO:0003100,GO:0003180,GO:0003180,GO:0003184,GO:0003203,GO:0003785,GO:0004517,GO:0004517,GO:0004517,GO:0004517,GO:0005515,GO:0005516,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0005886,GO:0005901,GO:0006527,GO:0006527,GO:0006809,GO:0006809,GO:0006813,GO:0006816,GO:0007005,GO:0007263,GO:0008217,GO:0008285,GO:0009408,GO:0009725,GO:0010181,GO:0010181,GO:0010544,GO:0010628,GO:0014740,GO:0014806,GO:0019430,GO:0020037,GO:0030324,GO:0030666,GO:0031284,GO:0031284,GO:0031284,GO:0031644,GO:0031663,GO:0032496,GO:0034405,GO:0034617,GO:0034618,GO:0042311,GO:0043267,GO:0043536,GO:0043542,GO:0045454,GO:0045747,GO:0045766,GO:0045766,GO:0045776,GO:0046870,GO:0048662,GO:0048873,GO:0050660,GO:0050660,GO:0050661,GO:0051649,GO:0051926,GO:0060412,GO:0070168,GO:0097110,GO:0097746,GO:1902042

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NOS3 hsa:4846 path:hsa00220 Arginine biosynthesis - Homo sapiens (human)
NOS3 hsa:4846 path:hsa00330 Arginine and proline metabolism - Homo sapiens (human)
NOS3 hsa:4846 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04611 Platelet activation - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04931 Insulin resistance - Homo sapiens (human)
NOS3 hsa:4846 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
NOS3 hsa:4846 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
NOS3 hsa:4846 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
NOS3 hsa:4846 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOS3 ATP2B1 20211863 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATP2B2 NOS3 20211863 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOS3 ATP2B4 20211863 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOS3 ACTN2 18180332 23180781 physical association two hybrid InnateDB
NOS3 ACTN4 18180332 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
CALM1 NOS3 19358819 23180781 physical association comigration in non denaturing gel electrophoresis InnateDB
NOS3 VDAC2 22842492 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOS3 VDAC1 22842492 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CAV1 NOS3 20005715 interaction type N/A PSP
PPP2R5A NOS3 20005715 interaction type N/A PSP
CAV1 NOS3 18988627 20005715 21071413 8910295 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ATF2 NOS3 16497991 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ERG NOS3 11013235 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ETS1 NOS3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NOS3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NOS3 10713142 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA4 NOS3 14555463 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
NFKB1 NOS3 17081374 17644577 18397880 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 NOS3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
RELA NOS3 17081374 18397880 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 NOS3 10713142 12270858 12759366 15722551 18624763 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP3 NOS3 12759366 14555463 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
STAT3 NOS3 16887796 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
SMARCA4 NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NOS3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DDIT3 NOS3 22265908 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 NOS3 22848708 trascriptional regulation,stimulation inferred by curator TFlink
JUN NOS3 11382920 trascriptional regulation,stimulation inferred by curator TFlink
KLF2 NOS3 22987017 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 NOS3 10713142 12270858 15722551 18624763 trascriptional regulation,stimulation inferred by curator TFlink
EPAS1 NOS3 N/A trascriptional regulation,stimulation inferred by curator TFlink
ESR1 NOS3 N/A trascriptional regulation,stimulation inferred by curator TFlink
ESR2 NOS3 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETV4 NOS3 N/A trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NOS3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A NOS3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 NOS3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 NOS3 23108656 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000338542 NOS3 23108656 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 NOS3 18185580 25416803 26647850 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171525 NOS3 25416803 27917915 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000019F055 NOS3 25416803 26647850 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA1 NOS3 22135298 phosphorylation N/A PhosphoSite
PRKACA NOS3 22135298 phosphorylation N/A PhosphoSite
PTK2B NOS3 22135298 phosphorylation N/A PhosphoSite
CDK5 NOS3 22135298 phosphorylation N/A PhosphoSite
PRKG2 NOS3 22135298 phosphorylation N/A PhosphoSite
PRKCA NOS3 22135298 phosphorylation N/A PhosphoSite
AKT1 NOS3 22135298 phosphorylation N/A PhosphoSite
NOS3 NOS3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 NOS3 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NOS3 BDKRB2 10510297 10681501 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NOS3 BDNF 10493752 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NOS3 HSP90AA1 11744239 11988487 12124224 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NOS3 NMT1 14525934 25348397 7512951 N/A experimental interaction detection,in vivo ComPPI,HPRD
NOS3 AKT1 10376603 11696579 14525934 23397142 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
NOS3 SP1 14525934 25348397 7541039 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NOS3 CAV1 14525934 17502619 24234451 25348397 8910295 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
NOS3 PPP2R5A 11397791 12501214 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NOS3 EDNRB 10510297 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NOS3 NOSIP 11149895 14525934 16135813 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
NOS3 AGTR1 25348397 N/A in vitro ComPPI
NOS3 HSP90AA2P 25348397 N/A physical interaction ComPPI
NOS3 GUCY1B1 25348397 N/A physical interaction ComPPI
NOS3 NOSTRIN 12446846 16234328 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
NOS3 CALM1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
NOS3 HDAC3 25348397 N/A physical interaction ComPPI
NOS3 CAMK2A 25348397 N/A physical interaction ComPPI
NOS3 APP 25348397 N/A physical interaction ComPPI
NOS3 CDC37 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction,two hybrid array ComPPI,IntAct
NOS3 ST13 21163940 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
NOS3 ST13P4 25348397 N/A physical interaction ComPPI
NOS3 GCDH 21163940 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,confocal microscopy ComPPI,IntAct
NOS3 A2M 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOS3 EXOC6 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOS3 MAST1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOS3 ELAVL3 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOS3 PI4K2A 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOS3 ELAVL1 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOS3 KANK2 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOS3 RNF32 21163940 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NOS3 APOE 25348397 N/A physical interaction ComPPI
NOS3 CEP55 25348397 N/A physical interaction ComPPI
NOS3 EXOSC1 25348397 N/A physical interaction ComPPI
NOS3 PAXIP1 25348397 N/A physical interaction ComPPI
NOS3 PSEN2 25348397 N/A physical interaction ComPPI
NOS3 PSEN1 25348397 N/A physical interaction ComPPI
NOS3 EFEMP1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 FIS1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 EFEMP2 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 RNF31 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 UMPS 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 IMMT 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 MPRIP 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 HTRA1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 TXNDC11 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 ACTN2 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 ACTN4 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 H3-3A 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NOS3 TECR 25348397 N/A physical interaction ComPPI
NOS3 ACTB 17502619 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NOS3 MAGEA11 25348397 N/A physical interaction ComPPI
NOS3 SIRT1 20479254 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NOS3 ESR1 17921256 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NOS3 HBA1 23123858 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOS3 DNM1 16432212 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NOS3 CTNNB1 24234451 25062958 25348397 27898060 physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct,OmniPath
NOS3 IKZF3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NOS3 NOS3 12437348 14525934 9516116 N/A experimental interaction detection HPRD
NOS3 CALM2 11397791 24234451 physical association anti bait coimmunoprecipitation IntAct
NOS3 TRPV1 21493704 22451268 27898060 N/A N/A OmniPath
CDK5 NOS3 16270749 19962452 20213743 27898060 inhibition N/A OmniPath
PRKACA NOS3 11729179 24379783 27898060 stimulant N/A OmniPath
PRKCA NOS3 24379783 27898060 inhibition N/A OmniPath
PRKCB NOS3 24379783 27898060 inhibition N/A OmniPath
PRKCE NOS3 24379783 27898060 inhibition N/A OmniPath
EGFR NOS3 10376603 12171920 12446767 12501214 12791703 16043647 16126727 27898060 N/A N/A OmniPath
PRKCD NOS3 24379783 27898060 inhibition,stimulant N/A OmniPath
PRKAB1 NOS3 11729179 27898060 stimulant N/A OmniPath
AKT1 NOS3 10376603 11425855 11696579 11729179 18048761 20166139 20363286 23397142 24379783 25241761 27898060 stimulant N/A OmniPath
PRKCG NOS3 24379783 27898060 inhibition N/A OmniPath
PRKCQ NOS3 24379783 27898060 inhibition N/A OmniPath
TP53 NOS3 18431400 27898060 inhibition N/A OmniPath
HSP90AA1 NOS3 11425855 11744239 11988487 12124224 12676772 27898060 9580552 stimulant N/A OmniPath
PRKCZ NOS3 24379783 27898060 inhibition N/A OmniPath
PPP1CB NOS3 19036824 27898060 stimulant N/A OmniPath
PRKACG NOS3 11729179 27898060 stimulant N/A OmniPath
SP1 NOS3 27898060 7541039 stimulant N/A OmniPath
PPP1CA NOS3 19036824 27898060 stimulant N/A OmniPath
AKT3 NOS3 24379783 27898060 stimulant N/A OmniPath
PRKCI NOS3 24379783 27898060 inhibition N/A OmniPath
AKT2 NOS3 24379783 27898060 stimulant N/A OmniPath
HSP90AB1 NOS3 27898060 9580552 stimulant N/A OmniPath
NMT1 NOS3 27898060 7512951 N/A N/A OmniPath
PPP1CC NOS3 19036824 27898060 stimulant N/A OmniPath
PRKAA1 NOS3 10376603 11029403 11319202 11402048 11425855 11978735 12446767 12522122 12644590 12791703 16043647 16338973 16873402 16946136 17572401 18303014 23768697 24379783 26132171 27898060 inhibition,stimulant N/A OmniPath
PTK2B NOS3 18483407 19934023 27898060 inhibition N/A OmniPath
PRKG2 NOS3 10671564 11292821 12574113 12644458 15136572 16126727 16428343 16497987 16527820 16527893 16754797 17116756 18622039 21757745 27898060 N/A N/A OmniPath
PPP2R5A NOS3 11397791 12501214 27898060 N/A N/A OmniPath
PRKCH NOS3 24379783 27898060 inhibition N/A OmniPath

Visualization










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