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GENE：PIK3CB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIK3CB
FullNmae phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8976
EnsembleID ENSG00000051382
Uniprot P42338

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIK3CB necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3CB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3CB autophagy 26018563 However, the orthodox paradigm is challenged by findings that the PIK3CB catalytic subunit of class I PI3K acts as a positive regulator of autophagy, and PIK3C3 was thought to be an amino acid sensor for MTOR, which curbs autophagy. retulator signature
PIK3CB autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PIK3CB apoptosis 35842767 Silencing PIK3CB inhibited the proliferation of ESCC cells, arrested the cell cycle, and promoted apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
PIK3CB GO:0001935,GO:0001952,GO:0002931,GO:0003376,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0005943,GO:0005943,GO:0006874,GO:0006897,GO:0006914,GO:0006935,GO:0007156,GO:0007165,GO:0007169,GO:0007186,GO:0010508,GO:0010595,GO:0010628,GO:0016301,GO:0016303,GO:0016303,GO:0016310,GO:0016477,GO:0016477,GO:0030168,GO:0030496,GO:0033031,GO:0035005,GO:0035022,GO:0036092,GO:0040016,GO:0043231,GO:0043407,GO:0043491,GO:0043491,GO:0043491,GO:0043491,GO:0043491,GO:0043560,GO:0046854,GO:0046934,GO:0046934,GO:0048015,GO:0051000,GO:0051897,GO:0051898,GO:0060055,GO:0070527,GO:0106310,GO:1900747,GO:1903298,GO:1903671,GO:2000369

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIK3CB hsa:5291 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa01522 Endocrine resistance - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04210 Apoptosis - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04218 Cellular senescence - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04360 Axon guidance - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04510 Focal adhesion - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04611 Platelet activation - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04929 GnRH secretion - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04931 Insulin resistance - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05020 Prion disease - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05131 Shigellosis - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05132 Salmonella infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05135 Yersinia infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05142 Chagas disease - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05146 Amoebiasis - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05160 Hepatitis C - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05161 Hepatitis B - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05162 Measles - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05164 Influenza A - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05210 Colorectal cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05213 Endometrial cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05214 Glioma - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05215 Prostate cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05218 Melanoma - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05224 Breast cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05226 Gastric cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
PIK3CB hsa:5291 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIK3R1 PIK3CB 14729945 23180781 phosphorylation reaction anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
PIK3R1 PIK3CB 20005715 interaction type N/A PSP
YWHAQ PIK3CB 20005715 interaction type N/A PSP
YWHAQ PIK3CB 20005715 20005715 N/A N/A SignaLink
PIK3R1 PIK3CB 20005715 20005715 21071413 8139559 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PIK3CB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PIK3CB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PIK3CB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 PIK3CB 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 PIK3CB 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PIK3CB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PIK3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIK3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIK3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIK3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIK3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PIK3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PIK3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PIK3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB PIK3CB 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000018CD09 PIK3CB 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003AA845 PIK3CB 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIK3CB PIK3CB 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIK3R2 PIK3CB 19380743 22402981 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PCBP1 PIK3CB 25348397 N/A physical interaction ComPPI
CRK PIK3CB 25348397 N/A physical interaction ComPPI
PAK1 PIK3CB 24234451 25348397 25843002 association pull down ComPPI,IntAct
CBL PIK3CB 19380743 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TGFBR2 PIK3CB 25348397 N/A physical interaction ComPPI
PIK3R1 PIK3CB 10358930 14525934 20713702 24234451 25241761 25348397 26496610 8139559 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
PRKCD PIK3CB 11676480 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GAB2 PIK3CB 25348397 N/A physical interaction ComPPI
GRB2 PIK3CB 21706016 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCE PIK3CB 14525934 25348397 9822674 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIK3CB AGTR2 11459796 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3CB MME 12529960 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIK3CB HCK 12029088 14525934 23397142 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
PIK3CB ALK 25348397 N/A physical interaction ComPPI
PIK3CB DVL3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3CB HPS6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3CB ALAS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3CB RAB5A 25348397 N/A physical interaction ComPPI
PIK3CB IRS1 25348397 N/A physical interaction ComPPI
PIK3CB EGFR 25348397 N/A physical interaction ComPPI
PIK3CB EFNB2 25348397 N/A physical interaction ComPPI
PIK3CB PTGER3 25348397 N/A physical interaction ComPPI
PIK3CB NTRK1 25348397 N/A physical interaction ComPPI
PIK3CB AKT1 25348397 N/A physical interaction ComPPI
PIK3CB AKT2 25348397 N/A physical interaction ComPPI
PIK3CB PIK3R3 22402981 24234451 25348397 25814554 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array ComPPI,IntAct
PIK3CB ERBB3 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3CB HAVCR2 25348397 N/A physical interaction ComPPI
PIK3CB FLRT1 25348397 N/A physical interaction ComPPI
PIK3CB NLGN3 25348397 N/A physical interaction ComPPI
PIK3CB CDH5 25348397 N/A physical interaction ComPPI
PIK3CB ZDHHC1 25348397 N/A physical interaction ComPPI
PIK3CB CHRM3 25348397 N/A physical interaction ComPPI
PIK3CB TMEM52B 25348397 N/A physical interaction ComPPI
PIK3CB CACNG5 25348397 N/A physical interaction ComPPI
PIK3CB IL20RA 25348397 N/A physical interaction ComPPI
PIK3CB RNF19B 25348397 N/A physical interaction ComPPI
PIK3CB RAPGEF5 25348397 N/A physical interaction ComPPI
PIK3CB MANSC1 25348397 N/A physical interaction ComPPI
PIK3CB P4HA2 25348397 N/A physical interaction ComPPI
PIK3CB DOCK5 25348397 N/A physical interaction ComPPI
PIK3CB WDR26 25348397 N/A physical interaction ComPPI
PIK3CB GNB1 25348397 N/A physical interaction ComPPI
PIK3CB NBN 20368419 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3CB TFCP2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
YWHAQ PIK3CB 14525934 24234451 25348397 7479742 physical association coimmunoprecipitation,experimental interaction detection,filter binding,in vitro,in vivo ComPPI,HPRD,IntAct
SEPTIN9 PIK3CB 24234451 30021884 physical association cross-linking study IntAct
PCNA PIK3CB 19416922 27898060 N/A N/A OmniPath
PTEN PIK3CB 18794881 27898060 inhibition N/A OmniPath
ITGB4 PIK3CB 11733063 12867433 27898060 7721947 8143784 9428518 stimulant N/A OmniPath
HRAS PIK3CB 21779497 27898060 stimulant N/A OmniPath
IRS1 PIK3CB 11416002 27898060 stimulant N/A OmniPath
PIK3AP1 PIK3CB 22187458 27898060 stimulant N/A OmniPath
PIK3R1 PIK3CB 10358930 14729945 20713702 22939629 25241761 26344197 26496610 27898060 8139559 stimulant N/A OmniPath
PIK3CB PIK3R1 10358930 14729945 20713702 22939629 25241761 26344197 26496610 27898060 8139559 N/A N/A OmniPath
TNF PIK3CB 10485710 27898060 stimulant N/A OmniPath
NRAS PIK3CB 21779497 27898060 stimulant N/A OmniPath
MAPK1 PIK3CB 12502714 27898060 N/A N/A OmniPath
ERBB4 PIK3CB 16729043 27898060 stimulant N/A OmniPath
ERBB3 PIK3CB 16729043 27898060 stimulant N/A OmniPath
KRAS PIK3CB 21779497 27898060 stimulant N/A OmniPath

Visualization










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