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GENE：PIK3CD

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIK3CD
FullNmae phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8977
EnsembleID ENSG00000171608
Uniprot O00329

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIK3CD necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3CD mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3CD lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
PIK3CD lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PIK3CD immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3CD apoptosis 39424707 PIK3CD-AS2 overexpression regulates NS1 protein-induced cell cycle arrest and initiates apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
PIK3CD GO:0001779,GO:0001819,GO:0001938,GO:0002250,GO:0002551,GO:0002679,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0005942,GO:0005942,GO:0005943,GO:0005943,GO:0006468,GO:0006954,GO:0006955,GO:0007165,GO:0010595,GO:0010628,GO:0010818,GO:0016301,GO:0016303,GO:0016303,GO:0016303,GO:0016310,GO:0016477,GO:0030101,GO:0030183,GO:0030217,GO:0030217,GO:0030335,GO:0030593,GO:0033031,GO:0035005,GO:0035747,GO:0035754,GO:0036092,GO:0038089,GO:0042110,GO:0042113,GO:0043303,GO:0043491,GO:0043491,GO:0043491,GO:0043491,GO:0045087,GO:0045766,GO:0046934,GO:0048015,GO:0050852,GO:0050853,GO:0051897,GO:0060374,GO:0072672,GO:1905278

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIK3CD hsa:5293 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa01522 Endocrine resistance - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04210 Apoptosis - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04218 Cellular senescence - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04360 Axon guidance - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04510 Focal adhesion - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04611 Platelet activation - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04929 GnRH secretion - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04931 Insulin resistance - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05020 Prion disease - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05131 Shigellosis - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05132 Salmonella infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05135 Yersinia infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05142 Chagas disease - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05146 Amoebiasis - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05160 Hepatitis C - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05161 Hepatitis B - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05162 Measles - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05164 Influenza A - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05210 Colorectal cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05213 Endometrial cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05214 Glioma - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05215 Prostate cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05218 Melanoma - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05224 Breast cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05226 Gastric cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
PIK3CD hsa:5293 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HRAS PIK3CD 10545207 23180781 9113989 physical association two hybrid,gst pull down InnateDB
PIK3R1 PIK3CD 12147247 23180781 9113989 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
PIK3R2 PIK3CD 23180781 9113989 physical association gst pull down InnateDB
PIK3CD PIK3R3 23180781 9113989 physical association gst pull down InnateDB
PIK3CD PIK3CD 10455108 23180781 29145629 9113989 9885561 phosphorylation reaction,physical association inferred by curator,in-gel kinase assay InnateDB,Reactome
RACK1 PIK3CD 11801604 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3CD PIK3AP1 24243840 29145629 physical association inferred by curator Reactome
PIK3CD CD19 10706702 15187135 29145629 7528218 7687428 7687539 7691807 physical association inferred by curator Reactome
PIK3CD VAV1 10706702 15187135 29145629 7528218 7687428 7687539 7691807 physical association inferred by curator Reactome
PIK3CD LYN 10194437 10455108 11598010 12506011 15149544 29145629 9334184 physical association inferred by curator Reactome
PIK3CD IRS2 10194437 10455108 11598010 12506011 15149544 29145629 9334184 physical association inferred by curator Reactome
PIK3CD FYN 18374639 29145629 7537740 8995358 9259313 9525940 9590251 physical association inferred by curator Reactome
PIK3CD PIK3R1 10455108 24243840 29145629 9885561 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
IRS2 PIK3CD 20005715 interaction type N/A PSP,SignaLink
NCK1 PIK3CD 20005715 interaction type N/A PSP,SignaLink
PIK3R1 PIK3CD 20005715 interaction type N/A PSP
PIK3R1 PIK3CD 20005715 20005715 21071413 9113989 9113989 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PIK3CD 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PIK3CD 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PIK3CD 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PIK3CD 18971253 19638627 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PIK3CD 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 PIK3CD 23486085 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000065D58 PIK3CD 23486085 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004AC389 PIK3CD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004929F1 PIK3CD 24523440 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000C85B2 PIK3CD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 PIK3CD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F PIK3CD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039A052 PIK3CD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B0E50 PIK3CD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005E1A16 PIK3CD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001A7F58 PIK3CD 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003B59DF PIK3CD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000078918 PIK3CD 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 PIK3CD 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIK3CD PIK3CD 22135298 phosphorylation N/A PhosphoSite
HRAS PIK3CD 25361965 interaction type N/A PTMCode2
PIK3CD HRAS 25361965 interaction type N/A PTMCode2
IRS2 PIK3CD 25361965 interaction type N/A PTMCode2
PIK3CD IRS2 25361965 interaction type N/A PTMCode2
PTEN PIK3CD 25361965 interaction type N/A PTMCode2
PIK3CD PTEN 25361965 interaction type N/A PTMCode2
KITLG PIK3CD 25361965 interaction type N/A PTMCode2
PIK3CD KITLG 25361965 interaction type N/A PTMCode2
PIK3R1 PIK3CD 25361965 interaction type N/A PTMCode2
PIK3CD PIK3R1 25361965 interaction type N/A PTMCode2
PIK3R2 PIK3CD 25361965 interaction type N/A PTMCode2
PIK3CD PIK3R2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 PIK3CD 25348397 N/A physical interaction ComPPI
TNIP1 PIK3CD 25348397 N/A physical interaction ComPPI
CRK PIK3CD 25348397 N/A physical interaction ComPPI
HRAS PIK3CD 22020336 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3R1 PIK3CD 21827948 22020336 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,molecular sieving,pull down,physical interaction,protein kinase assay,confocal microscopy,mass spectrometry study of hydrogen/deuterium exchange ComPPI,IntAct
NCK1 PIK3CD 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
PIK3CG PIK3CD 25348397 N/A physical interaction ComPPI
PIK3R3 PIK3CD 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TAGLN PIK3CD 22798525 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RALY PIK3CD 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TNPO2 PIK3CD 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ASCC2 PIK3CD 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
AKT2 PIK3CD 25348397 N/A physical interaction ComPPI
MCRIP2 PIK3CD 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PIK3CD CD37 22624718 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PIK3CD RACK1 11801604 27898060 N/A N/A OmniPath
PIK3CD PIK3R2 19380743 27898060 9113989 N/A N/A OmniPath
ITGB4 PIK3CD 27898060 9428518 stimulant N/A OmniPath
HRAS PIK3CD 10545207 11739523 21779497 22020336 27898060 9113989 9235916 stimulant N/A OmniPath
PIK3CD PIK3R1 12147247 22020336 26496610 27898060 9113989 N/A N/A OmniPath
ERBB4 PIK3CD 16729043 27898060 stimulant N/A OmniPath
ERBB3 PIK3CD 16729043 27898060 stimulant N/A OmniPath
KRAS PIK3CD 21779497 27898060 stimulant N/A OmniPath
PIK3CD PIK3R3 27898060 9113989 N/A N/A OmniPath
CDK19 PIK3CD 10064595 27898060 N/A N/A OmniPath

Visualization










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