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GENE：PIK3CG

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIK3CG
FullNmae phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8978
EnsembleID ENSG00000105851
Uniprot P48736

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIK3CG lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
PIK3CG lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PIK3CG immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIK3CG apoptosis 39245801 Furthermore, overexpression of PIK3CG could protect AC16 from hypoxia/reoxygenation (H/R)-induced apoptosis, while the case was opposite for PIK3CG silencing. retulator signature

Go Annotation:

GeneSymbol Go id
PIK3CG GO:0001525,GO:0001819,GO:0002250,GO:0002407,GO:0002675,GO:0002679,GO:0003376,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005943,GO:0005943,GO:0005944,GO:0005944,GO:0006897,GO:0006954,GO:0006955,GO:0007186,GO:0007186,GO:0007204,GO:0010595,GO:0010818,GO:0010897,GO:0016020,GO:0016020,GO:0016301,GO:0016303,GO:0016303,GO:0016303,GO:0016310,GO:0016477,GO:0030593,GO:0032252,GO:0033628,GO:0035005,GO:0035005,GO:0035022,GO:0035747,GO:0036092,GO:0042098,GO:0042110,GO:0042802,GO:0043303,GO:0043406,GO:0043491,GO:0043491,GO:0043491,GO:0043491,GO:0045087,GO:0045765,GO:0046854,GO:0046875,GO:0046934,GO:0048015,GO:0051897,GO:0055118,GO:0070527,GO:0071320,GO:0072672,GO:0097284,GO:0106310,GO:1903169,GO:2000270

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIK3CG hsa:5294 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04611 Platelet activation - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa05132 Salmonella infection - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
PIK3CG hsa:5294 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HRAS PIK3CG 10922060 23180781 physical association two hybrid InnateDB
IL1RAP PIK3CG 15044087 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3CG LCK 17998387 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3CG ZAP70 17998387 23180781 physical association anti tag coimmunoprecipitation InnateDB
GNA11 PIK3CG 17998387 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3CG CXCR4 17998387 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3CG PRKCZ 16527821 23180781 physical association anti tag coimmunoprecipitation InnateDB
PIK3CG LYN 10318860 23180781 physical association affinity technology InnateDB
IRS1 PIK3CG 11943559 23331499 stimulation N/A SignaLink,SignaLink
PIK3CG RAC1 15009099 23331499 stimulation N/A SignaLink,SignaLink
IRS4 PIK3CG 16933034 23331499 stimulation N/A SignaLink,SignaLink
IGF1R PIK3CG 11278269 23331499 stimulation N/A SignaLink,SignaLink
LTK PIK3CG 23331499 9223670 stimulation N/A SignaLink,SignaLink
GRAP PIK3CG 23331499 7608146 stimulation N/A SignaLink
IRS2 PIK3CG 11943559 23331499 stimulation N/A SignaLink
TGFBR1 PIK3CG 15657037 23331499 stimulation N/A SignaLink
AXL PIK3CG 12470648 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GAB1 PIK3CG 20005715 interaction type N/A PSP
GRB2 PIK3CG 20005715 interaction type N/A PSP
GRB2 PIK3CG 10386953 18988627 20005715 N/A N/A SignaLink
GAB1 PIK3CG 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PIK3CG 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PIK3CG 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PIK3CG 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PIK3CG 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001D69F6 PIK3CG 22900072 23142521 25416803 26659078 27729613 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay TarBase
URS0000521626 PIK3CG 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 PIK3CG 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001B341F PIK3CG 24086481 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016D2D4 PIK3CG 24522205 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001E0AEA PIK3CG 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 PIK3CG 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB PIK3CG 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000759F6E PIK3CG 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 PIK3CG 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 PIK3CG 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 PIK3CG 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 PIK3CG 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F PIK3CG 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 PIK3CG 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 PIK3CG 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 PIK3CG 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE PIK3CG 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000007340 PIK3CG 25347932 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase
URS000052E1A6 PIK3CG 25416803 26998071 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS00000EED18 PIK3CG 25416803 27073535 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS00001F0C23 PIK3CG 25416803 26622553 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
PIK3CG SRC 22135298 phosphorylation N/A PhosphoSite
PIK3CG PIK3CG 22135298 phosphorylation N/A PhosphoSite
PRKCB PIK3CG 22135298 phosphorylation N/A PhosphoSite
HRAS PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG HRAS 25361965 interaction type N/A PTMCode2
GAB1 PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG GAB1 25361965 interaction type N/A PTMCode2
KIT PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG KIT 25361965 interaction type N/A PTMCode2
GRB2 PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG GRB2 25361965 interaction type N/A PTMCode2
PIK3R1 PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG PIK3R1 25361965 interaction type N/A PTMCode2
CD28 PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG CD28 25361965 interaction type N/A PTMCode2
PIK3R2 PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG PIK3R2 25361965 interaction type N/A PTMCode2
BCR PIK3CG 25361965 interaction type N/A PTMCode2
PIK3CG BCR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PRKAA2 PIK3CG 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KRAS PIK3CG 10542052 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SET PIK3CG 25348397 N/A physical interaction ComPPI
HRAS PIK3CG 11136978 14525934 24234451 25348397 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
SYK PIK3CG 25348397 N/A physical interaction ComPPI
IL6ST PIK3CG 10579793 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
KIT PIK3CG 14525934 24234451 25241761 25348397 7520444 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
LYN PIK3CG 10318860 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN11 PIK3CG 10386953 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NOTCH1 PIK3CG 14525934 14583609 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3CG EPHA8 11416136 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIK3CG GRK2 12163475 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3CG SMPD2 11238738 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3CG SEC14L2 12757856 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PIK3CG PIK3R5 10488142 12507995 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
PIK3CG CD28 14525934 25348397 9915850 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3CG GRB2 10386953 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3CG TPM2 14525934 16094730 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIK3CG GSN 11577104 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIK3CG BCR 24234451 25241761 25348397 27898060 7606002 physical association physical interaction,proximity ligation assay ComPPI,IntAct,OmniPath
PIK3CG ERAS 25348397 N/A physical interaction ComPPI
PIK3CG PIK3CD 25348397 N/A physical interaction ComPPI
PIK3CG NRAS 25348397 N/A physical interaction ComPPI
PIK3CG USP45 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3CG GABARAPL1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3CG UTRN 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3CG PRMT7 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3CG ZNF282 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3CG BECN1 19050071 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3CG PRKCB 25348397 N/A physical interaction,protein kinase assay,protein kinase assay ComPPI
PIK3CG CD37 22624718 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PIK3CG PDE3B 21393242 24234451 25348397 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct
GAB1 PIK3CG 10871282 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PIK3CG PIK3CG 20562859 23824069 24234451 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay IntAct
LCK PIK3CG 17998387 27898060 stimulant N/A OmniPath
PIK3CG LYN 10318860 27898060 7721825 N/A N/A OmniPath
PRKCB PIK3CG 23824069 27898060 N/A N/A OmniPath
PRKCD PIK3CG 12502714 27898060 N/A N/A OmniPath
ITGB4 PIK3CG 11733063 12867433 27898060 7721947 8143784 9428518 stimulant N/A OmniPath
CXCR4 PIK3CG 17998387 27898060 stimulant N/A OmniPath
HRAS PIK3CG 10922060 11136978 21779497 27898060 9727023 stimulant N/A OmniPath
CD28 PIK3CG 18006698 27898060 9915850 stimulant N/A OmniPath
IGF1R PIK3CG 11278269 27898060 stimulant N/A OmniPath
PIK3CG PDPK1 27898060 9768361 stimulant N/A OmniPath
IRS1 PIK3CG 11943559 27898060 stimulant N/A OmniPath
GNA11 PIK3CG 17998387 27898060 N/A N/A OmniPath
PIK3CG RAC1 15009099 27898060 stimulant N/A OmniPath
PIK3AP1 PIK3CG 22187458 27898060 stimulant N/A OmniPath
IRS2 PIK3CG 11943559 12850284 27898060 stimulant N/A OmniPath
PRKCZ PIK3CG 16527821 27898060 N/A N/A OmniPath
TNF PIK3CG 10485710 27898060 stimulant N/A OmniPath
PIK3CG NFE2L2 19272177 27898060 N/A N/A OmniPath
PIK3CG SET 21419339 27898060 8131851 N/A N/A OmniPath
NRAS PIK3CG 21779497 27898060 stimulant N/A OmniPath
ERBB4 PIK3CG 16729043 27898060 stimulant N/A OmniPath
ERBB3 PIK3CG 16729043 27898060 stimulant N/A OmniPath
TGFBR1 PIK3CG 15657037 27898060 stimulant N/A OmniPath
PIK3CG ZAP70 17998387 27898060 N/A N/A OmniPath
LTK PIK3CG 27898060 9223670 stimulant N/A OmniPath
KRAS PIK3CG 10542052 21779497 27898060 9727023 stimulant N/A OmniPath
IRS4 PIK3CG 16933034 27898060 stimulant N/A OmniPath
GRAP PIK3CG 27898060 7608146 stimulant N/A OmniPath
AXL PIK3CG 12470648 27898060 stimulant N/A OmniPath
GNGT1 PIK3CG 12507995 27898060 stimulant N/A OmniPath
PIK3CG TPM2 16094730 27898060 N/A N/A OmniPath

Visualization










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