GENE：PLA2G1B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PLA2G1B |
| FullNmae | phospholipase A2 group IB |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9030 |
| EnsembleID | ENSG00000170890 |
| Uniprot | P04054 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PLA2G1B | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PLA2G1B | GO:0002227,GO:0002446,GO:0004623,GO:0005102,GO:0005102,GO:0005102,GO:0005509,GO:0005509,GO:0005543,GO:0005576,GO:0005615,GO:0006633,GO:0006633,GO:0006644,GO:0007015,GO:0007165,GO:0008284,GO:0009986,GO:0010524,GO:0016042,GO:0019370,GO:0019731,GO:0030593,GO:0032052,GO:0032431,GO:0032757,GO:0032869,GO:0035556,GO:0043406,GO:0045944,GO:0046324,GO:0046470,GO:0046471,GO:0047498,GO:0047498,GO:0048146,GO:0048146,GO:0050482,GO:0050714,GO:0050778,GO:0050830,GO:0051092,GO:0061844,GO:1904635 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PLA2G1B | hsa:5319 | path:hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa00565 | Ether lipid metabolism - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa00591 | Linoleic acid metabolism - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa00592 | alpha-Linolenic acid metabolism - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| PLA2G1B | hsa:5319 | path:hsa04975 | Fat digestion and absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | PLA2G1B | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PLA2G1B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | PLA2G1B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PLA2G1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PLA2G1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PLA2G1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PLA2G1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PLA2G1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PLA2G1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PLAA | PLA2G1B | 14525934 2052621 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PLA2G2A | PLA2G1B | 14525934 25348397 7721806 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PLA2G1B | BGN | 14525934 25348397 9848887 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PLA2G1B | CSF3R | 14525934 14557262 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| PLA2G1B | SOCS2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| GRPR | PLA2G1B | 17251915 27898060 | stimulant | N/A | OmniPath |