GENE：PLA2G2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PLA2G2A |
| FullNmae | phospholipase A2 group IIA |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9031 |
| EnsembleID | ENSG00000188257 |
| Uniprot | P14555 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PLA2G2A | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PLA2G2A | GO:0004623,GO:0005509,GO:0005543,GO:0005543,GO:0005576,GO:0005615,GO:0005615,GO:0005741,GO:0005783,GO:0005789,GO:0005886,GO:0006644,GO:0006644,GO:0006954,GO:0010744,GO:0016042,GO:0030141,GO:0031640,GO:0034374,GO:0036335,GO:0042130,GO:0046337,GO:0046470,GO:0046473,GO:0047498,GO:0047498,GO:0047498,GO:0048471,GO:0050482,GO:0050729,GO:0050830,GO:0050830,GO:0070062,GO:0070374,GO:1902563 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PLA2G2A | hsa:5320 | path:hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa00565 | Ether lipid metabolism - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa00591 | Linoleic acid metabolism - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa00592 | alpha-Linolenic acid metabolism - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| PLA2G2A | hsa:5320 | path:hsa04975 | Fat digestion and absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | PLA2G2A | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | PLA2G2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PLA2G2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PLA2G2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PLA2G2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | PLA2G2A | 11899260 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | PLA2G2A | 11899260 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| USP20 | PLA2G2A | 25348397 | N/A | physical interaction | ComPPI |
| VIM | PLA2G2A | 12829607 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| USP7 | PLA2G2A | 25348397 | N/A | physical interaction | ComPPI |
| TGM2 | PLA2G2A | 25348397 | N/A | physical interaction | ComPPI |
| ITGAV | PLA2G2A | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | PLA2G1B | 14525934 25348397 7721806 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PLA2G2A | CRMP1 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| PLA2G2A | ALOX12 | 14525934 15474031 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| PLA2G2A | DCN | 10747008 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| PLA2G2A | CEP70 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PLA2G2A | BAG6 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | UCHL5 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | UCHL3 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | USP8 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | USP5 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | USP4 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | USP28 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | USP2 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | USP15 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | UCHL1 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | SENP8 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | ITGB3 | 25348397 | N/A | physical interaction | ComPPI |
| PLA2G2A | CRELD2 | 21900206 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| PLA2G2A | VCAN | 14525934 27898060 8824283 9848887 | N/A | experimental interaction detection | HPRD,OmniPath |