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GENE：PLA2G4A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLA2G4A
FullNmae phospholipase A2 group IVA
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9035
EnsembleID ENSG00000116711
Uniprot P47712

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLA2G4A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLA2G4A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLA2G4A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PLA2G4A GO:0000139,GO:0001516,GO:0001516,GO:0001516,GO:0002827,GO:0004622,GO:0004623,GO:0004623,GO:0005509,GO:0005509,GO:0005544,GO:0005544,GO:0005634,GO:0005635,GO:0005737,GO:0005743,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005829,GO:0005829,GO:0005829,GO:0006071,GO:0006640,GO:0006663,GO:0006690,GO:0008374,GO:0010314,GO:0010572,GO:0019369,GO:0019369,GO:0019370,GO:0032266,GO:0032308,GO:0034478,GO:0034638,GO:0036151,GO:0042127,GO:0043032,GO:0043231,GO:0046475,GO:0047498,GO:0047498,GO:0047498,GO:0047499,GO:0050482,GO:0051649,GO:0070273,GO:0071236,GO:0102545,GO:1902387

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLA2G4A hsa:5321 path:hsa00564 Glycerophospholipid metabolism - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa00565 Ether lipid metabolism - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa00590 Arachidonic acid metabolism - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa00591 Linoleic acid metabolism - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04217 Necroptosis - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04611 Platelet activation - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04730 Long-term depression - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PLA2G4A hsa:5321 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KSR1 PLA2G4A 10843677 11034387 11062502 11385609 11907067 14764585 15169888 15536084 15547943 15735649 17178906 17395718 18775330 19114553 19541618 19565474 22435554 24027568 26192618 8381049 9510155 interaction type N/A ACSN
JAK1 PLA2G4A 23180781 8612580 physical association anti tag coimmunoprecipitation InnateDB
CASP1 PLA2G4A 23180781 9875225 cleavage reaction protease assay InnateDB
CASP3 PLA2G4A 23180781 9875225 cleavage reaction enzymatic study,protease assay InnateDB
CASP7 PLA2G4A 23180781 9875225 cleavage reaction enzymatic study,protease assay InnateDB
CASP8 PLA2G4A 23180781 9875225 cleavage reaction enzymatic study,protease assay InnateDB
JUN PLA2G4A 21268080 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 PLA2G4A 21268080 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRC PLA2G4A 20379791 23180781 physical association anti tag coimmunoprecipitation InnateDB
NR3C1 PLA2G4A 17901074 20203101 23180781 physical association anti tag coimmunoprecipitation InnateDB
CREB1 PLA2G4A 20203101 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACTB PLA2G4A 18948217 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACTG1 PLA2G4A 18948217 23180781 physical association anti tag coimmunoprecipitation InnateDB
VIM PLA2G4A 18840708 23180781 physical association anti tag coimmunoprecipitation InnateDB
NOS2 PLA2G4A 18029351 23180781 physical association anti tag coimmunoprecipitation InnateDB
PTGS2 PLA2G4A 18029351 23180781 physical association anti tag coimmunoprecipitation InnateDB
ANXA1 PLA2G4A 17873281 23180781 physical association anti tag coimmunoprecipitation InnateDB
PRKCA PLA2G4A 16963226 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
ALOX12 PLA2G4A 15474031 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYBL2 PLA2G4A 14769798 23180781 physical association anti tag coimmunoprecipitation InnateDB
NCF2 PLA2G4A 12913107 23180781 physical association anti tag coimmunoprecipitation InnateDB
NCF1 PLA2G4A 12913107 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLA2G4A NCF1 12913107 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLA2G4A CYBB 12913107 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLA2G4A NCF2 12913107 23180781 physical association anti tag coimmunoprecipitation InnateDB
S100A10 PLA2G4A 12163506 23180781 physical association anti tag coimmunoprecipitation InnateDB
KAT5 PLA2G4A 11416127 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
ANXA5 PLA2G4A 10704651 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 PLA2G4A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR3C1 PLA2G4A 17901074 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
MYC PLA2G4A 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PLA2G4A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PLA2G4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLA2G4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PLA2G4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PLA2G4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PLA2G4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PLA2G4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PLA2G4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PLA2G4A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 PLA2G4A N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN PLA2G4A N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 PLA2G4A N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A PLA2G4A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 PLA2G4A 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000050CCE0 PLA2G4A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 PLA2G4A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002198F3 PLA2G4A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D5FFC PLA2G4A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E PLA2G4A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A PLA2G4A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 PLA2G4A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 PLA2G4A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 PLA2G4A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 PLA2G4A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 PLA2G4A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A PLA2G4A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 PLA2G4A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000EBD4B PLA2G4A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 PLA2G4A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C PLA2G4A 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK1 PLA2G4A 22135298 phosphorylation N/A PhosphoSite
VIM PLA2G4A 25361965 interaction type N/A PTMCode2
PLA2G4A VIM 25361965 interaction type N/A PTMCode2
CASP3 PLA2G4A 25361965 interaction type N/A PTMCode2
PLA2G4A CASP3 25361965 interaction type N/A PTMCode2
MAPKAPK5 PLA2G4A 25361965 interaction type N/A PTMCode2
PLA2G4A MAPKAPK5 25361965 interaction type N/A PTMCode2
MAPK14 PLA2G4A 25361965 interaction type N/A PTMCode2
PLA2G4A MAPK14 25361965 interaction type N/A PTMCode2
PLA2G4A MKNK1 25361965 interaction type N/A PTMCode2
MKNK1 PLA2G4A 25361965 interaction type N/A PTMCode2
PLA2G4A PLA2G5 25361965 interaction type N/A PTMCode2
PLA2G5 PLA2G4A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ANXA1 PLA2G4A 17873281 25348397 27898060 N/A physical interaction ComPPI,OmniPath
VIM PLA2G4A 10625659 14525934 18840708 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
BORCS6 PLA2G4A 18330356 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK1 PLA2G4A 25348397 N/A physical interaction ComPPI
PRKCA PLA2G4A 25348397 N/A physical interaction ComPPI
CASP3 PLA2G4A 14525934 25348397 9875225 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK3 PLA2G4A 25348397 N/A physical interaction ComPPI
MAPKAPK5 PLA2G4A 10978317 14525934 25348397 8636128 9468497 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPK14 PLA2G4A 14525934 25348397 9468497 N/A experimental interaction detection,in vivo ComPPI,HPRD
MYBL2 PLA2G4A 14769798 25348397 27898060 N/A physical interaction ComPPI,OmniPath
JAK1 PLA2G4A 14525934 25348397 8612580 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP1 PLA2G4A 14525934 25348397 9875225 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB3 PLA2G4A 25348397 N/A physical interaction ComPPI
ITGA2B PLA2G4A 25348397 N/A physical interaction ComPPI
MYC PLA2G4A 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NCF1 PLA2G4A 25348397 N/A physical interaction ComPPI
S100A11 PLA2G4A 25348397 N/A physical interaction ComPPI
RELA PLA2G4A 18330356 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK2 PLA2G4A 25348397 N/A physical interaction ComPPI
RPS6KA5 PLA2G4A 10978317 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ANXA2 PLA2G4A 25348397 N/A physical interaction ComPPI
SIRT2 PLA2G4A 25348397 N/A physical interaction ComPPI
PLA2G4A KAT5 11416127 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PLA2G4A CASP4 14525934 25348397 9875225 N/A experimental interaction detection,in vivo ComPPI,HPRD
PLA2G4A RUVBL2 25348397 N/A physical interaction ComPPI
PLA2G4A CAP1 18330356 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PLA2G4A UBXN1 18330356 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PLA2G4A XAGE1A 25348397 N/A physical interaction ComPPI
PLA2G4A S100A10 25348397 N/A physical interaction ComPPI
PLA2G4A ANXA2P2 25348397 N/A physical interaction ComPPI
PLA2G4A EHD1 22456504 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PLA2G4A MOV10 25348397 N/A physical interaction ComPPI
PLA2G4A NXF1 25348397 N/A physical interaction ComPPI
PLA2G4A STAT3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PLA2G4A ALOX12 25348397 N/A physical interaction ComPPI
PLA2G4A NCF1B 25348397 N/A physical interaction ComPPI
PLA2G4A NCF2 25348397 N/A physical interaction ComPPI
PLA2G4A CCNA2 25348397 N/A physical interaction ComPPI
PLA2G4A TRIM25 25348397 N/A physical interaction ComPPI
PLA2G4A ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SHBG PLA2G4A 25348397 N/A physical interaction ComPPI
CKB PLA2G4A 25348397 N/A physical interaction ComPPI
PLA2G4A PLA2G5 12124392 14525934 N/A experimental interaction detection HPRD
PLA2G4A PLA2G4A 14525934 9430701 N/A experimental interaction detection HPRD
MKNK1 PLA2G4A 10978317 14525934 8636128 9468497 N/A experimental interaction detection HPRD
DDX1 PLA2G4A 24234451 30021884 physical association cross-linking study IntAct
ANXA5 PLA2G4A 10704651 27898060 N/A N/A OmniPath
PRKCA PLA2G4A 16963226 27898060 stimulant N/A OmniPath
PRKCE PLA2G4A 10978317 15539760 27898060 9468497 N/A N/A OmniPath
PLA2G4A CASP1 27898060 9875225 N/A N/A OmniPath
RPS6KA5 PLA2G4A 10978317 16964243 18212344 18669648 19664994 20068231 27898060 stimulant N/A OmniPath
PLA2G4A CASP7 27898060 9875225 N/A N/A OmniPath
PLA2G4A CASP3 27898060 9875225 N/A N/A OmniPath
PLA2G4A KAT5 11416127 27898060 N/A N/A OmniPath
MAPK3 PLA2G4A 27898060 8381049 stimulant N/A OmniPath
PLA2G4A JAK1 27898060 8612580 N/A N/A OmniPath
MAPK14 PLA2G4A 10978317 20068231 27898060 8636128 8910365 9468497 stimulant N/A OmniPath
PLA2G4A CASP8 27898060 9875225 N/A N/A OmniPath
MAPK1 PLA2G4A 11737068 12576304 12885780 14530366 15826939 18280113 18632668 19176526 27898060 7766652 8636128 9468497 stimulant N/A OmniPath
CAMK2A PLA2G4A 11479288 27898060 N/A N/A OmniPath
MAPKAPK5 PLA2G4A 10978317 16964243 18212344 18669648 19664994 20068231 27898060 8636128 9468497 stimulant N/A OmniPath
MKNK1 PLA2G4A 10978317 16964243 18212344 18669648 19664994 20068231 27898060 8636128 9468497 stimulant N/A OmniPath

Visualization










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