GENE：PLA2G6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PLA2G6 |
| FullNmae | phospholipase A2 group VI |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9039 |
| EnsembleID | ENSG00000184381 |
| Uniprot | O60733 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PLA2G6 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PLA2G6 | GO:0003847,GO:0004622,GO:0004623,GO:0005515,GO:0005516,GO:0005615,GO:0005739,GO:0005829,GO:0005886,GO:0006935,GO:0015630,GO:0016290,GO:0016290,GO:0016607,GO:0016787,GO:0017171,GO:0019731,GO:0031143,GO:0032049,GO:0034638,GO:0035774,GO:0035965,GO:0035965,GO:0038096,GO:0042802,GO:0046338,GO:0046469,GO:0046473,GO:0047499,GO:0047499,GO:0102545,GO:0102991,GO:2000304 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PLA2G6 | hsa:8398 | path:hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa00565 | Ether lipid metabolism - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa00591 | Linoleic acid metabolism - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa00592 | alpha-Linolenic acid metabolism - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| PLA2G6 | hsa:8398 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PLA2G6 | ARF1 | 20881058 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PLA2G6 | SREBF2 | 15450207 23180781 | physical association | electrophoretic mobility shift assay | InnateDB |
| PLA2G6 | SREBF1 | 15450207 23180781 | physical association | electrophoretic mobility shift assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PLA2G6 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PLA2G6 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | PLA2G6 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PLA2G6 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | PLA2G6 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PLA2G6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | PLA2G6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BAG3 | PLA2G6 | 25348397 | N/A | physical interaction | ComPPI |
| CALM1 | PLA2G6 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | PLA2G6 | 25348397 | N/A | physical interaction | ComPPI |
| SDCBP | PLA2G6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SERTAD2 | PLA2G6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| RUSC1 | PLA2G6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HIF1AN | PLA2G6 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| MAT2B | PLA2G6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NUP93 | PLA2G6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CEP76 | PLA2G6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| RCBTB2 | PLA2G6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TRIM50 | PLA2G6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PLA2G6 | ZBTB42 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PLA2G6 | PLA2G6 | 24234451 | physical association | two hybrid array,two hybrid prey pooling approach | IntAct |
| PLA2G6 | SREBF1 | 15450207 27898060 | N/A | N/A | OmniPath |
| PLA2G6 | ARF1 | 20881058 27898060 | N/A | N/A | OmniPath |