Gene Information gene info

GENE:PRF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRF1
FullNmae perforin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9360
EnsembleID ENSG00000180644
Uniprot P14222

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRF1 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
PRF1 apoptosis 38791196 Additionally, differential expression of prf1 and gzmb genes was screened from spotted sea bass, with experimental evidence indicating that PRF1 and GZMB protein from spotted sea bass primarily induce apoptosis in transplanted fat greenling spermatogonia via the mitochondrial apoptosis pathway, at the protein level. retulator signature

Go Annotation:

GeneSymbol Go id
PRF1 GO:0001771,GO:0001771,GO:0001772,GO:0001913,GO:0001913,GO:0002357,GO:0002418,GO:0005509,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0006915,GO:0006968,GO:0009306,GO:0016020,GO:0016020,GO:0017038,GO:0022829,GO:0022829,GO:0031640,GO:0031904,GO:0042802,GO:0044194,GO:0044194,GO:0051260,GO:0051607,GO:0051607,GO:0051712,GO:0071806,GO:0140507,GO:0140911

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRF1 hsa:5551 path:hsa04210 Apoptosis - Homo sapiens (human)
PRF1 hsa:5551 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PRF1 hsa:5551 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
PRF1 hsa:5551 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
PRF1 hsa:5551 path:hsa05330 Allograft rejection - Homo sapiens (human)
PRF1 hsa:5551 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
PRF1 hsa:5551 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PRF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PRF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PRF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PRF1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PRF1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT4 PRF1 12372421 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 PRF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT3 PRF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A PRF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B PRF1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
SRGN PRF1 11911826 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
KRT31 PRF1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRF1 CALR 14525934 25348397 27898060 9671507 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PRF1 DDX24 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRF1 TRIM54 25348397 N/A physical interaction ComPPI
PRF1 FBXO6 25348397 N/A physical interaction ComPPI
PRF1 GZMB 11911826 14525934 24234451 25348397 27898060 8770355 physical association anti bait coimmunoprecipitation,experimental interaction detection ComPPI,HPRD,IntAct,OmniPath
PRF1 CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRF1 NOTCH2NLA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRF1 PRF1 21037563 21685908 24234451 physical association transmission electron microscopy,electron tomography,comigration in gel electrophoresis IntAct

Visualization