GENE:PRF1
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | PRF1 |
FullNmae | perforin 1 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:9360 |
EnsembleID | ENSG00000180644 |
Uniprot | P14222 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
PRF1 | immunogenic | 37275552 | To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. | retulator signature |
PRF1 | apoptosis | 38791196 | Additionally, differential expression of prf1 and gzmb genes was screened from spotted sea bass, with experimental evidence indicating that PRF1 and GZMB protein from spotted sea bass primarily induce apoptosis in transplanted fat greenling spermatogonia via the mitochondrial apoptosis pathway, at the protein level. | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
PRF1 | GO:0001771,GO:0001771,GO:0001772,GO:0001913,GO:0001913,GO:0002357,GO:0002418,GO:0005509,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0006915,GO:0006968,GO:0009306,GO:0016020,GO:0016020,GO:0017038,GO:0022829,GO:0022829,GO:0031640,GO:0031904,GO:0042802,GO:0044194,GO:0044194,GO:0051260,GO:0051607,GO:0051607,GO:0051712,GO:0071806,GO:0140507,GO:0140911 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
PRF1 | hsa:5551 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
PRF1 | hsa:5551 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
PRF1 | hsa:5551 | path:hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
PRF1 | hsa:5551 | path:hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
PRF1 | hsa:5551 | path:hsa05330 | Allograft rejection - Homo sapiens (human) |
PRF1 | hsa:5551 | path:hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
PRF1 | hsa:5551 | path:hsa05416 | Viral myocarditis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ETS1 | PRF1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA1 | PRF1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | PRF1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
YBX1 | PRF1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXP3 | PRF1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
SMARCA4 | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TRIM28 | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ZNF263 | PRF1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT4 | PRF1 | 12372421 | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT1 | PRF1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT3 | PRF1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT5A | PRF1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT5B | PRF1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
SRGN | PRF1 | 11911826 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
KRT31 | PRF1 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
PRF1 | CALR | 14525934 25348397 27898060 9671507 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
PRF1 | DDX24 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
PRF1 | TRIM54 | 25348397 | N/A | physical interaction | ComPPI |
PRF1 | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
PRF1 | GZMB | 11911826 14525934 24234451 25348397 27898060 8770355 | physical association | anti bait coimmunoprecipitation,experimental interaction detection | ComPPI,HPRD,IntAct,OmniPath |
PRF1 | CYSRT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
PRF1 | NOTCH2NLA | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
PRF1 | PRF1 | 21037563 21685908 24234451 | physical association | transmission electron microscopy,electron tomography,comigration in gel electrophoresis | IntAct |