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GENE：CEBPA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CEBPA
FullNmae CCAAT enhancer binding protein alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1833
EnsembleID ENSG00000245848
Uniprot P49715

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CEBPA necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CEBPA GO:0000050,GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001228,GO:0001889,GO:0001892,GO:0002070,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005730,GO:0006091,GO:0006351,GO:0006355,GO:0006357,GO:0006357,GO:0007005,GO:0007219,GO:0008203,GO:0008285,GO:0008285,GO:0010628,GO:0019221,GO:0019900,GO:0030099,GO:0030099,GO:0030225,GO:0030324,GO:0030851,GO:0031490,GO:0032436,GO:0036488,GO:0042593,GO:0042802,GO:0042803,GO:0043032,GO:0043231,GO:0045444,GO:0045600,GO:0045669,GO:0045736,GO:0045892,GO:0045944,GO:0045944,GO:0045944,GO:0048839,GO:0050729,GO:0050872,GO:0050873,GO:0055088,GO:0061629,GO:0070102,GO:0071285,GO:0071356,GO:0071407,GO:0071425,GO:0090575,GO:0090575,GO:0097677,GO:0140467,GO:1902034,GO:1990647

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CEBPA hsa:1050 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
CEBPA hsa:1050 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CEBPA hsa:1050 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
CEBPA hsa:1050 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CEBPA MYC 11340171 20581311 26192618 interaction type N/A ACSN
E2F1 CEBPA 19035457 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFATC4 CEBPA 20392859 23180781 physical association anti tag coimmunoprecipitation InnateDB
ALOX5AP CEBPA 12571239 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGAX CEBPA 23180781 9360988 physical association electrophoretic mobility supershift assay InnateDB
TLR9 CEBPA 15294971 23180781 physical association electrophoretic mobility shift assay InnateDB
MXD1 CEBPA 18203738 23180781 physical association anti tag coimmunoprecipitation InnateDB
CSF3 CEBPA 11830484 23180781 physical association electrophoretic mobility supershift assay InnateDB
CSF2RB CEBPA 10453008 23180781 physical association electrophoretic mobility supershift assay InnateDB
LTF CEBPA 12522000 15588942 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
NCOA6 CEBPA 11302752 23180781 physical association anti tag coimmunoprecipitation InnateDB
CSF3R CEBPA 14734562 23180781 physical association anti tag coimmunoprecipitation InnateDB
EPHX1 CEBPA 15150264 23180781 physical association electrophoretic mobility supershift assay InnateDB
NFYA CEBPA 15150264 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1A CEBPA 11818365 23180781 physical association electrophoretic mobility supershift assay InnateDB
SMARCA2 CEBPA 19054766 23180781 physical association anti tag coimmunoprecipitation InnateDB
VDR CEBPA 19054766 23180781 physical association anti tag coimmunoprecipitation InnateDB
CTNNA1 CEBPA 20371743 23180781 physical association anti tag coimmunoprecipitation InnateDB
NQO2 CEBPA 23180781 24142791 physical association anti tag coimmunoprecipitation InnateDB
CEBPA ALOX5AP 12571239 23180781 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR CEBPA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 CEBPA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CEBPA 18971253 19074951 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA2 CEBPA 19074951 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA3 CEBPA 19074951 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HNF4A CEBPA 18971253 19074951 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC CEBPA 12695333 15867211 19259613 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HNF1A CEBPA 19074951 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CEBPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CEBPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CEBPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CEBPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CEBPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CEBPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CEBPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CEBPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DDIT3 CEBPA 21983012 trascriptional regulation,stimulation inferred by curator TFlink
GATA1 CEBPA 19825991 trascriptional regulation,stimulation inferred by curator TFlink
LEF1 CEBPA 19620402 trascriptional regulation,stimulation inferred by curator TFlink
MYB CEBPA 10706719 trascriptional regulation,stimulation inferred by curator TFlink
PPARG CEBPA 15867211 trascriptional regulation,stimulation inferred by curator TFlink
ZBTB16 CEBPA 19723763 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CEBPA N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 CEBPA N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 CEBPA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB CEBPA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE CEBPA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000367985 CEBPA 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 CEBPA 22135298 phosphorylation N/A PhosphoSite
MAPK1 CEBPA 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HNRNPC CEBPA 25348397 N/A physical interaction ComPPI
RARA CEBPA 25348397 N/A physical interaction ComPPI
CDKN1A CEBPA 14525934 25348397 27898060 9372966 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
ATF4 CEBPA 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
CEBPG CEBPA 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
RARB CEBPA 25348397 N/A physical interaction ComPPI
EDF1 CEBPA 25348397 N/A physical interaction ComPPI
MCM5 CEBPA 25348397 N/A physical interaction ComPPI
SMAD4 CEBPA 25348397 N/A physical interaction ComPPI
BATF CEBPA 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
MAPK8 CEBPA 25348397 N/A physical interaction ComPPI
SPI1 CEBPA 12091339 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
JUN CEBPA 25348397 N/A physical interaction ComPPI
MAF CEBPA 25348397 N/A physical interaction ComPPI
RB1 CEBPA 10082561 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NFYA CEBPA 14525934 15150264 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
AR CEBPA 25348397 N/A physical interaction ComPPI
CREBBP CEBPA 12857754 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VDR CEBPA 25348397 N/A physical interaction ComPPI
EP300 CEBPA 11340085 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SMAD3 CEBPA 25348397 N/A physical interaction ComPPI
ATF3 CEBPA 25348397 N/A physical interaction ComPPI
HIF1A CEBPA 25348397 N/A physical interaction ComPPI
PIAS1 CEBPA 14525934 15588942 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CEBPB CEBPA 14525934 1840554 20102225 24234451 25348397 N/A experimental interaction detection,peptide array,physical interaction,in vitro ComPPI,HPRD,IntAct
SFPQ CEBPA 25348397 N/A physical interaction ComPPI
PKN2 CEBPA 25348397 N/A physical interaction ComPPI
GSK3B CEBPA 10567568 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UBTF CEBPA 20075868 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
POLR1E CEBPA 25348397 N/A physical interaction ComPPI
ACTN1 CEBPA 25348397 N/A physical interaction ComPPI
NR1I2 CEBPA 25348397 N/A physical interaction ComPPI
PARP1 CEBPA 16490787 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NCOA6 CEBPA 11302752 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
XRCC5 CEBPA 16490787 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMARCA4 CEBPA 25348397 N/A physical interaction ComPPI
MYC CEBPA 12873812 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRIB1 CEBPA 25348397 26455797 27898060 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI,OmniPath
XRCC6 CEBPA 16490787 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
C1QBP CEBPA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KLF5 CEBPA 21821915 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PPP2CA CEBPA 25348397 N/A physical interaction ComPPI
EWSR1 CEBPA 25348397 N/A physical interaction ComPPI
E2F4 CEBPA 25348397 N/A physical interaction ComPPI
ZBTB16 CEBPA 25348397 N/A physical interaction ComPPI
SUMO3 CEBPA 12511558 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CCDC183 CEBPA 25348397 N/A physical interaction ComPPI
SMC1A CEBPA 25348397 N/A physical interaction ComPPI
SPTBN1 CEBPA 25348397 N/A physical interaction ComPPI
CDK2 CEBPA 11684017 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SOX8 CEBPA 14525934 16582099 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HDAC2 CEBPA 25348397 N/A physical interaction ComPPI
SKP2 CEBPA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CEBPE CEBPA 12571239 23661758 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TGFB2 CEBPA 25348397 N/A physical interaction ComPPI
CTNNB1 CEBPA 12861022 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TRA2B CEBPA 25348397 N/A physical interaction ComPPI
NR3C1 CEBPA 11818365 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
RANBP2 CEBPA 25348397 N/A physical interaction ComPPI
NFATC4 CEBPA 25348397 N/A physical interaction ComPPI
CAPN2 CEBPA 25348397 N/A physical interaction ComPPI
ELAVL1 CEBPA 25348397 N/A physical interaction ComPPI
MPP2 CEBPA 25348397 N/A physical interaction ComPPI
CHD1 CEBPA 25348397 N/A physical interaction ComPPI
ESR1 CEBPA 25348397 N/A physical interaction ComPPI
CDK4 CEBPA 11684017 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ZEB2 CEBPA 25348397 N/A physical interaction ComPPI
GATA2 CEBPA 14525934 1563207 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SOX10 CEBPA 14525934 16582099 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MACF1 CEBPA 25348397 N/A physical interaction ComPPI
MNT CEBPA 25348397 N/A physical interaction ComPPI
ATF5 CEBPA 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
RBL1 CEBPA 10082561 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BATF2 CEBPA 25348397 N/A physical interaction ComPPI
RFC1 CEBPA 12509469 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ATF2 CEBPA 14525934 14734562 25348397 9139739 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CEBPA CEBPD 14525934 1840554 20102225 24234451 25348397 N/A experimental interaction detection,peptide array,in vitro ComPPI,HPRD,IntAct
CEBPA MSX2 12925529 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CEBPA CDKN3 11684017 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CEBPA DBP 14525934 25348397 27898060 8499951 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
CEBPA HNF1A 14525934 25348397 27898060 8288579 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CEBPA RUNX1 14525934 17431401 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CEBPA CDX1 14525934 19059241 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
CEBPA MAX 25348397 N/A physical interaction ComPPI
CEBPA SLC25A11 25348397 N/A physical interaction ComPPI
CEBPA RPGRIP1 25348397 N/A physical interaction ComPPI
CEBPA ZNF45 25348397 N/A physical interaction ComPPI
CEBPA MRTO4 25348397 N/A physical interaction ComPPI
CEBPA SMARCA2 25348397 N/A physical interaction ComPPI
CEBPA HDAC1 25348397 N/A physical interaction ComPPI
CEBPA KAT5 25348397 N/A physical interaction ComPPI
CEBPA SP110 25348397 N/A physical interaction ComPPI
CEBPA RAB34 25348397 N/A physical interaction ComPPI
CEBPA RAB34 25348397 N/A physical interaction ComPPI
CEBPA AK5 25348397 N/A physical interaction ComPPI
CEBPA PGAM1 25348397 N/A physical interaction ComPPI
CEBPA GFAP 25348397 N/A physical interaction ComPPI
CEBPA NAA16 25348397 N/A physical interaction ComPPI
CEBPA AKAP9 25348397 N/A physical interaction ComPPI
CEBPA ASXL1 25348397 N/A physical interaction ComPPI
CEBPA VPS72 25348397 N/A physical interaction ComPPI
CEBPA FUT1 25348397 N/A physical interaction ComPPI
CEBPA SRA1 25348397 N/A physical interaction ComPPI
CEBPA UBE3A 23598402 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CEBPA YY1AP1 25348397 N/A physical interaction ComPPI
CEBPA FOS 25348397 N/A physical interaction ComPPI
CEBPA FOSL1 25348397 N/A physical interaction ComPPI
CEBPA RASGRF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CEBPA BHLHE41 25348397 N/A physical interaction ComPPI
CEBPA DDIT3 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
CEBPA PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
BATF3 CEBPA 25348397 N/A physical interaction ComPPI
CEBPA CEBPA 11893744 14525934 20102225 24234451 N/A experimental interaction detection,peptide array HPRD,IntAct
BCL2 CEBPA 23814099 24234451 association chromatin immunoprecipitation assay IntAct
CEBPA FTO 24234451 24877091 association chromatin immunoprecipitation assay IntAct
CEBPA E2F1 19035457 27898060 N/A N/A OmniPath
CEBPA WDR5 26167872 27898060 N/A N/A OmniPath
NQO2 CEBPA 24142791 27898060 N/A N/A OmniPath
CEBPA CSF2RA 15676205 27898060 stimulant N/A OmniPath
CEBPA CSF3R 15676205 27898060 stimulant N/A OmniPath
CEBPA ELANE 15676205 27898060 stimulant N/A OmniPath
CEBPA SPI1 10397723 12091339 16983342 27898060 stimulant N/A OmniPath
GATA3 CEBPA 17139329 27898060 inhibition N/A OmniPath
ZBTB16 CEBPA 19723763 23898169 27898060 inhibition N/A OmniPath
SUMO3 CEBPA 12511558 27898060 N/A N/A OmniPath
CEBPA CSF1R 15676205 27898060 stimulant N/A OmniPath
MAPK3 CEBPA 14701740 27898060 inhibition N/A OmniPath
MAPK1 CEBPA 14701740 20101026 27898060 inhibition N/A OmniPath
CEBPA CD14 15676205 27898060 stimulant N/A OmniPath
CEBPA LYZ 15676205 27898060 stimulant N/A OmniPath
CEBPA SLC11A1 18786141 27898060 stimulant N/A OmniPath
GSK3B CEBPA 10567568 27898060 N/A N/A OmniPath
CEBPA LTF 10845904 27898060 stimulant N/A OmniPath
CEBPA MPO 15676205 27898060 stimulant N/A OmniPath
NR0B2 CEBPA 17094771 27898060 inhibition N/A OmniPath
PCSK7 CEBPA 19544470 27898060 inhibition N/A OmniPath

Visualization










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