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GENE：TNFSF10

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TNFSF10
FullNmae TNF superfamily member 10
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11925
EnsembleID ENSG00000121858
Uniprot P50591

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TNFSF10 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFSF10 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TNFSF10 apoptosis 30896802 In the present study, EFLDO was identified to sensitize HepG2 cells to tumor necrosis factor (TNF) superfamily member 10 (TNFSF10) induced apoptosis. retulator signature
TNFSF10 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TNFSF10 GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005576,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0007267,GO:0008270,GO:0008584,GO:0032868,GO:0042802,GO:0043065,GO:0043123,GO:0043123,GO:0043280,GO:0045569,GO:0070062,GO:0090200,GO:2001238,GO:2001238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TNFSF10 hsa:8743 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa04210 Apoptosis - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa04217 Necroptosis - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa05132 Salmonella infection - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa05164 Influenza A - Homo sapiens (human)
TNFSF10 hsa:8743 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TNFRSF10A TNFSF10 10894161 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B TNFSF10 10894161 16227629 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFSF10 CASP8 10894161 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD TNFSF10 10894161 16227629 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF3 TNFSF10 15994827 23180781 physical association biochemical InnateDB
IRF5 TNFSF10 19028697 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFSF10 STAT1 17617740 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 TNFSF10 15241475 17617740 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF2 TNFSF10 15241475 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFSF10 CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT5B TNFSF10 23180781 24497979 physical association anti tag coimmunoprecipitation InnateDB
TNFSF10 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
MACROH2A1 TNFSF10 23180781 24752897 physical association anti tag coimmunoprecipitation InnateDB
PELP1 TNFSF10 23180781 24752897 physical association anti tag coimmunoprecipitation InnateDB
RUNX1 TNFSF10 23180781 23492767 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TNFSF10 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TNFSF10 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TNFSF10 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 TNFSF10 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TNFSF10 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TNFSF10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TNFSF10 17932312 trascriptional regulation,stimulation inferred by curator TFlink
FOXO1 TNFSF10 23630076 trascriptional regulation,stimulation inferred by curator TFlink
FOXO3 TNFSF10 23630076 trascriptional regulation,stimulation inferred by curator TFlink
FOXO4 TNFSF10 23630076 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 TNFSF10 23630076 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 TNFSF10 21858676 trascriptional regulation,stimulation inferred by curator TFlink
NFIL3 TNFSF10 23630076 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TNFSF10 11544302 20542572 21243522 trascriptional regulation,stimulation inferred by curator TFlink
NFKBIA TNFSF10 11544302 trascriptional regulation,stimulation inferred by curator TFlink
PML TNFSF10 15459016 trascriptional regulation,stimulation inferred by curator TFlink
RELA TNFSF10 11544302 20542572 21243522 trascriptional regulation,stimulation inferred by curator TFlink
SP1 TNFSF10 21603612 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TNFSF10 21603612 trascriptional regulation,stimulation inferred by curator TFlink
JUN TNFSF10 N/A trascriptional regulation,stimulation inferred by curator TFlink
REL TNFSF10 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 TNFSF10 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 TNFSF10 18246122 rna interference,inhibition western blot miRSponge
URS0000153377 TNFSF10 18246122 rna interference,inhibition western blot miRSponge
URS0000153377 TNFSF10 18246122 25416803 mrna cleavage,inhibition western blot TarBase
URS0000170CF4 TNFSF10 18246122 25416803 mrna cleavage,inhibition western blot TarBase
URS0000122ED0 TNFSF10 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000C85B2 TNFSF10 25416803 27353001 mrna cleavage,inhibition western blot TarBase
URS00004AF715 TNFSF10 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000003ABC4 TNFSF10 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000031B6ED TNFSF10 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003E2232 TNFSF10 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001A4ABF TNFSF10 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000002569A TNFSF10 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TNFSF10 CASP10 25361965 interaction type N/A PTMCode2
CASP10 TNFSF10 25361965 interaction type N/A PTMCode2
TNFSF10 TNFRSF11B 25361965 interaction type N/A PTMCode2
TNFRSF11B TNFSF10 25361965 interaction type N/A PTMCode2
TNFSF10 FADD 25361965 interaction type N/A PTMCode2
FADD TNFSF10 25361965 interaction type N/A PTMCode2
TNFSF10 TNFRSF10D 25361965 interaction type N/A PTMCode2
TNFRSF10D TNFSF10 25361965 interaction type N/A PTMCode2
TNFSF10 TNFRSF10C 25361965 interaction type N/A PTMCode2
TNFRSF10C TNFSF10 25361965 interaction type N/A PTMCode2
TNFSF10 CASP8 25361965 interaction type N/A PTMCode2
CASP8 TNFSF10 25361965 interaction type N/A PTMCode2
TNFRSF10A TNFSF10 25361965 interaction type N/A PTMCode2
TNFSF10 TNFRSF10A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SOCS3 TNFSF10 25348397 N/A physical interaction ComPPI
TNFAIP3 TNFSF10 25348397 N/A physical interaction ComPPI
PAK1 TNFSF10 24234451 25348397 25843002 association pull down ComPPI,IntAct
CASP3 TNFSF10 25348397 N/A physical interaction ComPPI
ACP5 TNFSF10 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CUL3 TNFSF10 19427028 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP8 TNFSF10 10894160 12198154 16801533 19427028 20097879 21459798 21525171 21822306 22266862 23678861 24234451 25348397 colocalization,association anti tag coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
IER3 TNFSF10 15451437 24234451 25348397 physical association two hybrid ComPPI,IntAct
PPP2CA TNFSF10 25348397 N/A physical interaction ComPPI
FADD TNFSF10 10894160 12198154 16801533 19427028 20097879 21459798 21525171 21822306 22266862 23678861 24234451 25348397 association anti tag coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TRAF2 TNFSF10 25348397 N/A physical interaction ComPPI
ZDHHC17 TNFSF10 24234451 24705354 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP10 TNFSF10 23678861 24234451 25348397 association coimmunoprecipitation,pull down ComPPI,IntAct
RIPK1 TNFSF10 25348397 N/A physical interaction ComPPI
RBM48 TNFSF10 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CFLAR TNFSF10 20097879 23678861 24234451 25348397 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TNFRSF10A TNFSF10 10549288 10894160 14525934 19427028 20103630 24234451 25348397 9082980 9325248 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TNFRSF10B TNFSF10 10542098 10549288 10894160 14525934 19427028 20097879 20103630 21459798 21525171 21822306 22266862 23678861 24234451 25348397 9311998 9325248 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TNFSF10 TNFRSF11B 12221720 14525934 25348397 9520411 N/A experimental interaction detection,in vitro ComPPI,HPRD
TNFSF10 TNFRSF10C 14525934 20103630 24234451 25348397 9314565 9325248 9613612 N/A experimental interaction detection,surface plasmon resonance,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
TNFSF10 TNFRSF10D 14525934 20103630 24234451 25348397 9430226 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
TNFSF10 TNFSF10 10549288 14525934 N/A experimental interaction detection HPRD
FOXO3 TNFSF10 24234451 27451907 association chromatin immunoprecipitation assay IntAct
IRF1 TNFSF10 19129219 27898060 stimulant N/A OmniPath
TNFSF10 FADD 10894161 16227629 21822306 22266862 22585859 27898060 N/A N/A OmniPath
TNFRSF10C TNFSF10 20103630 27898060 9082980 9314565 9325248 9613612 inhibition N/A OmniPath
TNFSF10 TNFRSF10C 20103630 27898060 9082980 9314565 9325248 9613612 inhibition,stimulant N/A OmniPath
TNFSF10 TNFRSF10B 10542098 10549288 10894161 11094155 12628743 14585074 15538968 15766588 16227629 20103630 21822306 22585859 27898060 9242610 9311998 9325248 stimulant N/A OmniPath
TNFSF10 CASP8 10894161 21822306 22266862 22585859 23142077 23678861 24287696 27898060 stimulant N/A OmniPath
CASP8 TNFSF10 10894161 21822306 22266862 22585859 23142077 23678861 24287696 27898060 N/A N/A OmniPath
TNFSF10 TNFRSF10D 20103630 27898060 9242610 9382840 9430226 stimulant N/A OmniPath
TNFRSF10D TNFSF10 20103630 27898060 9382840 9430226 inhibition N/A OmniPath
TNFSF10 TNFRSF10A 10549288 10894161 12628743 14585074 15538968 15766588 20103630 27898060 9082980 9325248 stimulant N/A OmniPath

Visualization










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