Gene Information gene info

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GENE：LEFTY1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LEFTY1
FullNmae left-right determination factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6552
EnsembleID ENSG00000243709
Uniprot O75610

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LEFTY1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LEFTY1 GO:0000122,GO:0003007,GO:0005125,GO:0005160,GO:0005615,GO:0007179,GO:0007368,GO:0008083,GO:0009948

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LEFTY1 hsa:10637 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
LEFTY1 hsa:10637 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 LEFTY1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 LEFTY1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 LEFTY1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA LEFTY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LEFTY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LEFTY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LEFTY1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
POU5F1 LEFTY1 17068183 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070CD2 LEFTY1 21266536 rna interference,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS000041E949 LEFTY1 21266536 rna interference,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000070CD2 LEFTY1 21266536 22012620 25416803 mrna cleavage,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS000041E949 LEFTY1 21266536 22012620 25416803 mrna cleavage,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS0000508C13 LEFTY1 22012620 22020335 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00000B0E50 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000939AF LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001C85C7 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000023F008 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000030F801 LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002E628F LEFTY1 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MTOR LEFTY1 25348397 N/A physical interaction ComPPI
LEFTY1 TDGF1 22710174 27898060 N/A N/A OmniPath

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