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GENE：ELK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ELK1
FullNmae ETS transcription factor ELK1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3321
EnsembleID ENSG00000126767
Uniprot P19419

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ELK1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ELK1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ELK1 GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001889,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0006357,GO:0009416,GO:0010467,GO:0030154,GO:0030324,GO:0030374,GO:0030425,GO:0031966,GO:0043025,GO:0043679,GO:0045893,GO:0045893,GO:0045944,GO:0045944,GO:0061629,GO:0071394,GO:0071480,GO:0071774,GO:0110088,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ELK1 hsa:2002 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
ELK1 hsa:2002 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
ELK1 hsa:2002 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
ELK1 hsa:2002 path:hsa04510 Focal adhesion - Homo sapiens (human)
ELK1 hsa:2002 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
ELK1 hsa:2002 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
ELK1 hsa:2002 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
ELK1 hsa:2002 path:hsa05140 Leishmaniasis - Homo sapiens (human)
ELK1 hsa:2002 path:hsa05161 Hepatitis B - Homo sapiens (human)
ELK1 hsa:2002 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
ELK1 hsa:2002 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
ELK1 hsa:2002 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ELK1 hsa:2002 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ELK1 hsa:2002 path:hsa05213 Endometrial cancer - Homo sapiens (human)
ELK1 hsa:2002 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELK1 FOS 11274345 26192618 interaction type N/A ACSN
ELK1 MAPK8 23180781 8654373 8846788 phosphorylation reaction,physical association gst pull down,in-gel kinase assay InnateDB
ELK1 MAPK9 23180781 8654373 8846788 phosphorylation reaction,physical association gst pull down,in-gel kinase assay InnateDB
MAPK1 ELK1 15655247 15967991 23180781 phosphorylation reaction protein kinase assay InnateDB
MAPK3 ELK1 12473660 15967991 16291755 18988627 23180781 23331499 7601337 8208531 phosphorylation reaction,stimulation protein kinase assay InnateDB,SignaLink,SignaLink
MAPK10 ELK1 23180781 8654373 phosphorylation reaction,physical association gst pull down,in-gel kinase assay InnateDB
SNCA ELK1 11279280 23180781 physical association anti tag coimmunoprecipitation InnateDB
SNCB ELK1 11279280 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELK1 TLR9 15294971 23180781 physical association electrophoretic mobility shift assay InnateDB
ELK1 CDKN1A 21642427 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP ELK1 21832049 23180781 physical association protein array InnateDB
MAPK8 ELK1 23331499 7651411 stimulation N/A SignaLink,SignaLink
MAPK14 ELK1 18988627 23331499 8548291 8622669 9130707 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
EGR1 ELK1 18061571 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A ELK1 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
MYC ELK1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF ELK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ELK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
LMO2 ELK1 22517897 trascriptional regulation,stimulation inferred by curator TFlink
NR3C1 ELK1 17016446 trascriptional regulation,stimulation inferred by curator TFlink
AR ELK1 N/A trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 ELK1 N/A trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ELK1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB ELK1 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 ELK1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 ELK1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 ELK1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00003677B2 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411672 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004818BD ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F8 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000547F6A ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027F5F3 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000045ED38 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018E6CD ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002004E0 ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA ELK1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 ELK1 22135298 phosphorylation N/A PhosphoSite
MAPK14 ELK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK1 ELK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRPF4B ELK1 22135298 phosphorylation N/A PhosphoSite
RPS6KA5 ELK1 22135298 phosphorylation N/A PhosphoSite
ELK1 MAPK1 25361965 interaction type N/A PTMCode2
ELK1 SRF 25361965 interaction type N/A PTMCode2
SRF ELK1 25361965 interaction type N/A PTMCode2
ELK1 MAP2K1 25361965 interaction type N/A PTMCode2
MAP2K1 ELK1 25361965 interaction type N/A PTMCode2
ELK1 CEBPB 25361965 interaction type N/A PTMCode2
CEBPB ELK1 25361965 interaction type N/A PTMCode2
ELK1 FOS 25361965 interaction type N/A PTMCode2
FOS ELK1 25361965 interaction type N/A PTMCode2
ELK1 MAPK8 25361965 interaction type N/A PTMCode2
MAPK8 ELK1 25361965 interaction type N/A PTMCode2
ELK1 MAPK11 25361965 interaction type N/A PTMCode2
MAPK11 ELK1 25361965 interaction type N/A PTMCode2
ELK1 SNCA 25361965 interaction type N/A PTMCode2
SNCA ELK1 25361965 interaction type N/A PTMCode2
ELK1 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 ELK1 25361965 interaction type N/A PTMCode2
ELK1 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 ELK1 25361965 interaction type N/A PTMCode2
ELK1 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 ELK1 25361965 interaction type N/A PTMCode2
ELK1 MAPK14 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIAS2 ELK1 14525934 15920481 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
UBE2I ELK1 14525934 17036045 23395904 24234451 25348397 sumoylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,enzymatic study,in vitro ComPPI,HPRD,IntAct
STK16 ELK1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAPK9 ELK1 14525934 25348397 8548291 9130707 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAD2L2 ELK1 25348397 N/A physical interaction ComPPI
CDK6 ELK1 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CRK ELK1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PADI4 ELK1 25348397 N/A physical interaction ComPPI
MAPK1 ELK1 14525934 16291755 24234451 25348397 8208531 8386592 8586671 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro ComPPI,HPRD,IntAct
MAPK8 ELK1 14525934 25348397 8586671 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRB10 ELK1 14525934 25348397 8798570 N/A experimental interaction detection,in vivo ComPPI,HPRD
PLCG2 ELK1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
FLI1 ELK1 25348397 N/A physical interaction ComPPI
MAPK3 ELK1 12473660 14525934 16291755 24234451 25241761 25348397 8208531 phosphorylation reaction,physical association experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
GRB2 ELK1 14525934 25348397 8798570 N/A experimental interaction detection,in vivo ComPPI,HPRD
CREBBP ELK1 14525934 25348397 8941362 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SUMO1 ELK1 17036045 23395904 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction,comigration in sds page ComPPI,IntAct
EP300 ELK1 12514134 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
MAPK14 ELK1 14525934 25348397 8548291 8622669 9130707 N/A experimental interaction detection,in vitro ComPPI,HPRD
CEBPB ELK1 14525934 1547942 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SRF ELK1 10606656 14525934 25348397 9010223 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K1 ELK1 10716983 10997882 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELK1 TAOK2 12665513 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELK1 BRCA1 11313879 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ELK1 MAPK11 25348397 N/A in vitro ComPPI
ELK1 ID2 10022839 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ELK1 MAP2K3 25348397 N/A in vitro ComPPI
ELK1 ID1 10022839 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELK1 MOB4 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ELK1 KLF4 25348397 N/A physical interaction,in vivo ComPPI
ELK1 SNCA 11279280 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ELK1 EWSR1 25348397 N/A physical interaction ComPPI
ELK1 EMX1 25348397 N/A physical interaction ComPPI
ELK1 HOXB13 25348397 N/A physical interaction ComPPI
ELK1 HDAC1 25348397 N/A physical interaction ComPPI
ELK1 ELAVL1 25348397 N/A physical interaction ComPPI
ELK1 APP 25348397 N/A physical interaction ComPPI
ELK1 MAPK10 25348397 N/A physical interaction ComPPI
ELK1 FBXO25 25348397 N/A physical interaction ComPPI
ELK1 STARD3NL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ID3 ELK1 10022839 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELK1 FOS 14525934 7540136 N/A experimental interaction detection HPRD
PPP3CA ELK1 10329725 27898060 N/A N/A OmniPath
MAPK10 ELK1 27898060 8654373 stimulant N/A OmniPath
RPS6KA5 ELK1 11145955 27898060 stimulant N/A OmniPath
MAPK9 ELK1 17875713 27898060 8548291 8654373 8846788 9130707 stimulant N/A OmniPath
APP ELK1 21244100 21832049 27898060 N/A N/A OmniPath
ELK1 APP 21244100 21832049 27898060 N/A N/A OmniPath
MAPK3 ELK1 10637505 11145955 12473660 14499342 15782123 15967991 16291755 20371703 25241761 27898060 7618106 7889942 8208531 8262053 8548291 8586671 9130707 stimulant N/A OmniPath
CREBBP ELK1 27898060 8941362 stimulant N/A OmniPath
MAPK14 ELK1 11145955 11309409 20727996 27898060 8548291 8622669 8887554 9130707 stimulant N/A OmniPath
ELK1 MAPK1 10644696 11279280 11435472 11857080 12220533 12551925 12594221 12788955 15655247 15767678 15782123 15967991 16291755 20371703 21655091 27898060 7889942 8208531 8386592 8586671 8846788 9130707 9687507 N/A N/A OmniPath
MAPK1 ELK1 10637505 10644696 11279280 11309409 11435472 11701445 11857080 12220533 12551925 12594221 12788955 12887893 15655247 15767678 15782123 15967991 16291755 19690332 20126313 20371703 20727996 21655091 23322625 27898060 7889942 8208531 8386592 8477450 8586671 8846788 9130707 9501095 9687507 stimulant N/A OmniPath
ELK1 SNCA 11279280 27898060 N/A N/A OmniPath
MAPK8 ELK1 10637505 17875713 27898060 7651411 7889942 8586671 8654373 8846788 9501095 stimulant N/A OmniPath
SNCB ELK1 11279280 27898060 N/A N/A OmniPath
TAOK2 ELK1 12665513 27898060 stimulant N/A OmniPath
PPP3CB ELK1 10329725 27898060 N/A N/A OmniPath
PPP3CC ELK1 10329725 27898060 N/A N/A OmniPath
PRPF4B ELK1 10799319 11145955 23114923 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BC5ED ELK1 27087310 direct interaction,inhibition N/A NPInter

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