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GENE：GSN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GSN
FullNmae gelsolin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4620
EnsembleID ENSG00000148180
Uniprot P06396

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GSN necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSN ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSN apoptosis 27193608 GSN also regulates cell morphology, differentiation, movement, and apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
GSN GO:0002102,GO:0003779,GO:0005509,GO:0005515,GO:0005546,GO:0005576,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005925,GO:0006911,GO:0007015,GO:0007417,GO:0008154,GO:0010628,GO:0014891,GO:0015629,GO:0016528,GO:0030027,GO:0030031,GO:0030041,GO:0030041,GO:0030042,GO:0030478,GO:0030864,GO:0031648,GO:0034774,GO:0035994,GO:0036313,GO:0042989,GO:0045159,GO:0045335,GO:0046597,GO:0051014,GO:0051014,GO:0051014,GO:0051015,GO:0051016,GO:0051127,GO:0051693,GO:0051693,GO:0055119,GO:0060271,GO:0070062,GO:0071346,GO:0071801,GO:0072562,GO:0086003,GO:0097017,GO:0097284,GO:1902174,GO:1903903,GO:1903906,GO:1903909,GO:1903923,GO:1904813,GO:1990000,GO:2001269

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GSN hsa:2934 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
GSN hsa:2934 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
GSN hsa:2934 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL7R GSN 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR GSN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 GSN 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 GSN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GSN 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 GSN 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 GSN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 GSN 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 GSN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 GSN 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000048D44E GSN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000045147B GSN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 GSN 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD GSN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002971AB GSN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 GSN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F GSN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C GSN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA GSN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D GSN 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075D50C GSN 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC GSN 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
WASL GSN 25348397 N/A physical interaction ComPPI
VASP GSN 11093254 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ACTG1 GSN 11733011 14525934 25348397 7849017 N/A experimental interaction detection,in vitro ComPPI,HPRD
ACTB GSN 10945978 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
KEAP1 GSN 25348397 N/A physical interaction ComPPI
FBXO34 GSN 25348397 N/A physical interaction ComPPI
PTK2B GSN 12578912 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SRC GSN 25348397 N/A physical interaction ComPPI
CASP3 GSN 14525934 25348397 9323209 9671712 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIK3CG GSN 11577104 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRB2 GSN 12577067 24234451 25348397 association pull down ComPPI,IntAct
AR GSN 12941811 14525934 19574450 24234451 25348397 physical association two hybrid,experimental interaction detection,t7 phage display,physical interaction,in vivo ComPPI,HPRD,IntAct
FLNA GSN 25348397 N/A physical interaction ComPPI
ACTN4 GSN 11733011 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TOM1L1 GSN 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PIK3CA GSN 25348397 N/A physical interaction ComPPI
MAP1S GSN 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PFN2 GSN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PXN GSN 25348397 N/A physical interaction,in vivo ComPPI
IQGAP1 GSN 25348397 N/A physical interaction ComPPI
VCL GSN 11577104 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PTPN12 GSN 25348397 N/A physical interaction ComPPI
CFTR GSN 25348397 N/A physical interaction ComPPI
VDAC1 GSN 11039896 14525934 17254575 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
MYO18A GSN 25348397 N/A physical interaction ComPPI
TNIK GSN 10521462 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
THOC1 GSN 25348397 N/A physical interaction ComPPI
ARRB1 GSN 17620599 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSK GSN 10210201 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ARRB2 GSN 17620599 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MDM2 GSN 25348397 N/A physical interaction ComPPI
CDK2 GSN 25348397 N/A physical interaction ComPPI
EGFR GSN 20029029 24234451 25348397 physical association ubiquitin reconstruction ComPPI,IntAct
ITCH GSN 25348397 N/A physical interaction ComPPI
TMOD2 GSN 25348397 N/A physical interaction ComPPI
MYO6 GSN 25348397 N/A physical interaction ComPPI
CUL7 GSN 25348397 N/A physical interaction ComPPI
PSMD4 GSN 25348397 N/A physical interaction ComPPI
PPM1B GSN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CFLAR GSN 25348397 N/A physical interaction ComPPI
STK39 GSN 25348397 N/A physical interaction ComPPI
CLIC5 GSN 10793131 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP4 GSN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ESR1 GSN 21182205 24234451 25348397 25604459 association affinity chromatography technology,cosedimentation through density gradient,physical interaction,tandem affinity purification ComPPI,IntAct
FHIT GSN 12833632 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ESR2 GSN 21182203 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient ComPPI,IntAct
LIMK2 GSN 25348397 N/A in vitro ComPPI
SSH1 GSN 25348397 N/A physical interaction ComPPI
SYNPO GSN 25348397 N/A physical interaction ComPPI
DDX19B GSN 25348397 N/A physical interaction ComPPI
EIF3K GSN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ACTR2 GSN 25348397 N/A physical interaction ComPPI
ACTR1B GSN 25348397 N/A physical interaction ComPPI
MPG GSN 25348397 N/A physical interaction ComPPI
MYH9 GSN 25348397 N/A physical interaction ComPPI
DLST GSN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GSN ACTA1 10583954 10854330 14525934 24234451 25348397 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
GSN FN1 14525934 25348397 6092370 N/A experimental interaction detection,physical interaction ComPPI,HPRD
GSN PTK2 25348397 N/A physical interaction ComPPI
GSN APP 10329371 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
GSN PLCG1 25348397 N/A physical interaction ComPPI
GSN UBE2Q2 25348397 N/A physical interaction ComPPI
GSN FBXO25 25348397 N/A physical interaction ComPPI
GSN SDHB 25348397 N/A physical interaction ComPPI
GSN ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GSN TP53 25348397 N/A physical interaction ComPPI
GSN OBSL1 25348397 N/A physical interaction ComPPI
GSN GAS2L1 25348397 N/A physical interaction ComPPI
GSN LRRC39 25348397 N/A physical interaction ComPPI
GSN TMOD1 25348397 N/A physical interaction ComPPI
GSN PPP1R18 25348397 N/A physical interaction ComPPI
GSN RBM18 25348397 N/A physical interaction ComPPI
GSN HNRNPA1 25348397 N/A physical interaction ComPPI
GSN CAPZA2 25348397 N/A physical interaction ComPPI
GSN DBN1 25348397 N/A physical interaction ComPPI
GSN LIMA1 25348397 N/A physical interaction ComPPI
GSN MYO19 25348397 N/A physical interaction ComPPI
GSN BCL7C 25348397 N/A physical interaction ComPPI
GSN BCL7A 25348397 N/A physical interaction ComPPI
GSN LSP1 25348397 N/A physical interaction ComPPI
GSN TMOD3 25348397 N/A physical interaction ComPPI
GSN NEXN 25348397 N/A physical interaction ComPPI
GSN ACTBL2 25348397 N/A physical interaction ComPPI
GSN FBXO40 25348397 N/A physical interaction ComPPI
GSN PLEKHG6 25348397 N/A physical interaction ComPPI
GSN COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GSN CCND2 25348397 N/A physical interaction ComPPI
GSN GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DNALI1 GSN 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
SESTD1 GSN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DUX4 GSN 24234451 25348397 26816005 association pull down ComPPI,IntAct
BCAR1 GSN 11577104 14525934 N/A experimental interaction detection HPRD
ACT-3 GSN 12732734 24234451 N/A x-ray crystallography IntAct
MAPT GSN 24234451 26402096 association anti bait coimmunoprecipitation IntAct
L1TD1 GSN 24234451 25702638 association anti bait coimmunoprecipitation IntAct
SRC GSN 10210201 23791551 27898060 stimulant N/A OmniPath
CASP3 GSN 27898060 9323209 9671712 9930654 inhibition,stimulant N/A OmniPath
GSN CASP9 10660524 27898060 inhibition N/A OmniPath
IL7R GSN 20167604 27898060 N/A N/A OmniPath
GSN ACTG1 11733011 15526166 27898060 7849017 stimulant N/A OmniPath
CSK GSN 10210201 27898060 N/A N/A OmniPath

Visualization










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