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GENE：CASP4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP4
FullNmae caspase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1505
EnsembleID ENSG00000196954
Uniprot P49662

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP4 pyroptosis 35990672 As a result, CASP4, IGSF6 and IL1R1 were identified as the potential diagnostic and therapeutic targets for SCI by computational analysis, which were enriched in NF-κB and IL6-JAK-STATA3 signaling pathways. In the injured spinal cord, these three signatures were up-regulated and closely correlated with NLRP3 inflammasome formation and gasdermin D (GSDMD) -induced pyroptosis. retulator signature
CASP4 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP4 GO:0001530,GO:0004197,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005829,GO:0005829,GO:0005886,GO:0006508,GO:0006954,GO:0016540,GO:0032991,GO:0042742,GO:0042981,GO:0045087,GO:0050700,GO:0050727,GO:0050729,GO:0050830,GO:0051604,GO:0061702,GO:0070059,GO:0070269,GO:0097193,GO:0097194,GO:0097200,GO:0160074,GO:0160075,GO:1903265,GO:1904646,GO:2000494

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP4 hsa:837 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
CASP4 hsa:837 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CASP4 hsa:837 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
CASP4 hsa:837 path:hsa05131 Shigellosis - Homo sapiens (human)
CASP4 hsa:837 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOD2 CASP4 18511561 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP4 IL18 15326478 23180781 9121587 cleavage reaction,protein cleavage protease assay InnateDB
IL37 CASP4 12096920 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
FOXP3 CASP4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CASP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CASP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CASP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 CASP4 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT1 CASP4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CASP4 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
IL1B CASP4 25361965 interaction type N/A PTMCode2
CASP4 IL1B 25361965 interaction type N/A PTMCode2
CASP8 CASP4 25361965 interaction type N/A PTMCode2
CASP4 CASP8 25361965 interaction type N/A PTMCode2
CASP4 CARD16 25361965 interaction type N/A PTMCode2
CARD16 CASP4 25361965 interaction type N/A PTMCode2
XIAP CASP4 25361965 interaction type N/A PTMCode2
CASP4 XIAP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNRPA1 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP14 CASP4 14525934 25348397 9792675 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TRAF6 CASP4 25348397 N/A physical interaction ComPPI
CTNNBIP1 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
XIAP CASP4 25348397 N/A physical interaction ComPPI
GSDMD CASP4 24234451 25348397 26375003 protein cleavage protease assay,protein cleavage ComPPI,IntAct
CASP3 CASP4 14525934 25348397 9233763 9694885 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MSH6 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP8 CASP4 25348397 N/A physical interaction ComPPI
MYCBPAP CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCTN1 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
VDAC1 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SMC1A CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMC3 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP10 CASP4 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PLA2G4A CASP4 14525934 25348397 9875225 N/A experimental interaction detection,in vivo ComPPI,HPRD
SSR4 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF2S3 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
APAF1 CASP4 14525934 25348397 9539746 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL18 CASP4 14525934 15326478 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP4 NOD1 10329646 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP4 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP4 IL1B 14525934 1919001 25348397 7797510 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP4 DSP 14525934 15500642 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP4 MTHFD1L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 GSN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 DNAAF5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 SRPRB 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 NUP93 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 SLC25A22 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 SMC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 EIF2S3B 25348397 N/A physical interaction ComPPI
CASP4 GCN1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 USP9X 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 UFL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 VDAC3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 IL37 25348397 N/A physical interaction ComPPI
CASP4 APP 14525934 15123740 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
CASP4 ELF4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP4 MYH9 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP4 RS1 25348397 N/A physical interaction ComPPI
CASP4 CASP5 25348397 N/A physical interaction ComPPI
CASP4 NOD2 18511561 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 LSM10 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 UBXN1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 MDN1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 COPE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 SMC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 SNRNP200 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 UMPS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 SLC25A1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 HACD3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 TMEM147 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 PSMD6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 HIGD1A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CASP4 CCDC59 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SERPINB9 CASP4 10477277 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PSMB1 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP4 CASP4 10872455 14525934 N/A experimental interaction detection HPRD
CASP4 CASP1 12843244 27898060 9039262 9491891 stimulant N/A OmniPath
CASP4 NOD2 18511561 27898060 N/A N/A OmniPath
CASP4 CASP3 27898060 9233763 9694885 N/A N/A OmniPath
CASP4 IL18 15326478 27898060 9121587 N/A N/A OmniPath

Visualization










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