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GENE：NUMA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NUMA1
FullNmae nuclear mitotic apparatus protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8059
EnsembleID ENSG00000137497
Uniprot Q14980

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NUMA1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NUMA1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NUMA1 apoptosis 37462735 Knock-down of NUMA1 promoted cell apoptosis and suppressed cell proliferation and colony formation. retulator signature

Go Annotation:

GeneSymbol Go id
NUMA1 GO:0000132,GO:0000132,GO:0000132,GO:0000132,GO:0000922,GO:0000922,GO:0001578,GO:0005198,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005694,GO:0005813,GO:0005813,GO:0005819,GO:0005829,GO:0005829,GO:0005876,GO:0005876,GO:0005886,GO:0005938,GO:0006997,GO:0008017,GO:0008017,GO:0015631,GO:0016328,GO:0016363,GO:0019904,GO:0030425,GO:0030513,GO:0030953,GO:0030953,GO:0031116,GO:0031616,GO:0032388,GO:0032991,GO:0032991,GO:0035091,GO:0035371,GO:0036449,GO:0043025,GO:0044877,GO:0045618,GO:0051010,GO:0051011,GO:0051301,GO:0051321,GO:0051798,GO:0051984,GO:0055028,GO:0055048,GO:0060236,GO:0060236,GO:0061673,GO:0070062,GO:0070840,GO:0072686,GO:0090235,GO:0097427,GO:0097431,GO:0097431,GO:0097575,GO:0097718,GO:0099738,GO:1902365,GO:1902846,GO:1904778,GO:1905720,GO:1905820,GO:1905832,GO:1990023

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EZH2 NUMA1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 NUMA1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
EED NUMA1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 NUMA1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
BMI1 NUMA1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR NUMA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 NUMA1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NUMA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NUMA1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 NUMA1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NUMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NUMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NUMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NUMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NUMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NUMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NUMA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 NUMA1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00007455B8 NUMA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000044FD7 NUMA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DC1D3 NUMA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000035D2F9 NUMA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B NUMA1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000027464B NUMA1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AURKA NUMA1 22135298 phosphorylation N/A PhosphoSite
CDK1 NUMA1 22135298 phosphorylation N/A PhosphoSite
ABL1 NUMA1 22135298 phosphorylation N/A PhosphoSite
CDK2 NUMA1 22135298 phosphorylation N/A PhosphoSite
AURKB NUMA1 22135298 phosphorylation N/A PhosphoSite
TNKS NUMA1 25361965 interaction type N/A PTMCode2
NUMA1 TNKS 25361965 interaction type N/A PTMCode2
EPB41 NUMA1 25361965 interaction type N/A PTMCode2
NUMA1 EPB41 25361965 interaction type N/A PTMCode2
NPM1 NUMA1 25361965 interaction type N/A PTMCode2
NUMA1 NPM1 25361965 interaction type N/A PTMCode2
GPSM2 NUMA1 25361965 interaction type N/A PTMCode2
NUMA1 GPSM2 25361965 interaction type N/A PTMCode2
NUMA1 PIM1 25361965 interaction type N/A PTMCode2
PIM1 NUMA1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GMCL1 NUMA1 25348397 N/A physical interaction ComPPI
CDC73 NUMA1 25348397 N/A physical interaction ComPPI
CBX8 NUMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNLL1 NUMA1 25348397 N/A physical interaction ComPPI
EIF3H NUMA1 25348397 N/A physical interaction ComPPI
NPM1 NUMA1 25348397 N/A physical interaction ComPPI
CDK6 NUMA1 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
TP53BP1 NUMA1 25348397 N/A physical interaction ComPPI
VCP NUMA1 25348397 N/A physical interaction ComPPI
LMNA NUMA1 25348397 N/A physical interaction ComPPI
BMI1 NUMA1 25348397 N/A physical interaction ComPPI
RAD21 NUMA1 25348397 N/A in vivo ComPPI
KEAP1 NUMA1 25348397 N/A physical interaction ComPPI
WDR83 NUMA1 25348397 N/A physical interaction ComPPI
HSP90AB1 NUMA1 16263121 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3E NUMA1 25348397 N/A physical interaction ComPPI
CRK NUMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TXNIP NUMA1 25348397 N/A physical interaction ComPPI
EZH2 NUMA1 25348397 N/A physical interaction ComPPI
ABRAXAS2 NUMA1 25348397 N/A physical interaction ComPPI
PIM1 NUMA1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
U2AF2 NUMA1 25348397 N/A physical interaction ComPPI
KPNB1 NUMA1 25348397 N/A physical interaction ComPPI
YWHAZ NUMA1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
HSP90AA1 NUMA1 25348397 N/A physical interaction ComPPI
NTRK1 NUMA1 25348397 N/A physical interaction ComPPI
ENO1 NUMA1 25348397 N/A physical interaction ComPPI
RUVBL1 NUMA1 25348397 N/A physical interaction ComPPI
NCOA6 NUMA1 25348397 N/A physical interaction,in vitro ComPPI
RPA1 NUMA1 25348397 N/A physical interaction ComPPI
DCTN1 NUMA1 23921553 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
PDHA1 NUMA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ECT2 NUMA1 25348397 N/A physical interaction ComPPI
KIF20A NUMA1 25348397 N/A physical interaction ComPPI
NUP98 NUMA1 25348397 N/A physical interaction ComPPI
RPA2 NUMA1 25348397 N/A physical interaction ComPPI
RPA3 NUMA1 25348397 N/A physical interaction ComPPI
YWHAQ NUMA1 25348397 N/A physical interaction ComPPI
ABCE1 NUMA1 25348397 N/A physical interaction ComPPI
RPS13 NUMA1 25348397 N/A physical interaction ComPPI
SUMO2 NUMA1 25348397 N/A physical interaction ComPPI
DVL1 NUMA1 25348397 N/A physical interaction ComPPI
DVL2 NUMA1 25348397 N/A physical interaction ComPPI
SMC1A NUMA1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
EPB41L3 NUMA1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPB41L1 NUMA1 10594058 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
ACTR1A NUMA1 10504299 25348397 27898060 N/A physical interaction,in vivo ComPPI,OmniPath
EPB41L2 NUMA1 12239178 25348397 27898060 N/A physical interaction,in vitro ComPPI,OmniPath
MPHOSPH8 NUMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 NUMA1 25348397 N/A physical interaction ComPPI
MED9 NUMA1 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BANF1 NUMA1 25348397 N/A physical interaction ComPPI
RNF2 NUMA1 25348397 N/A physical interaction ComPPI
YAP1 NUMA1 25348397 N/A physical interaction ComPPI
NCSTN NUMA1 25348397 N/A physical interaction ComPPI
GPSM2 NUMA1 11781568 15537540 24234451 25348397 27898060 association,physical association two hybrid,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct,OmniPath
SSX2IP NUMA1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I NUMA1 25348397 N/A physical interaction ComPPI
SMC3 NUMA1 25348397 N/A physical interaction ComPPI
SCOC NUMA1 25348397 N/A physical interaction ComPPI
MDC1 NUMA1 25348397 N/A physical interaction ComPPI
EED NUMA1 25348397 N/A physical interaction ComPPI
CUL7 NUMA1 25348397 N/A physical interaction ComPPI
H3C1 NUMA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HDAC5 NUMA1 25348397 N/A physical interaction ComPPI
DYNC1H1 NUMA1 25348397 N/A physical interaction ComPPI
SMURF1 NUMA1 25348397 N/A physical interaction ComPPI
TBK1 NUMA1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
DDB1 NUMA1 25348397 N/A physical interaction ComPPI
TERF1 NUMA1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
TNKS NUMA1 25348397 N/A physical interaction,in vivo ComPPI
RAE1 NUMA1 17172455 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ESR1 NUMA1 21182205 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,physical interaction ComPPI,IntAct
DVL3 NUMA1 25348397 N/A physical interaction ComPPI
BRCA1 NUMA1 25348397 N/A physical interaction ComPPI
BRD4 NUMA1 25348397 N/A physical interaction ComPPI
TNKS2 NUMA1 22153077 24234451 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
YEATS4 NUMA1 10913114 11521196 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
TERF2 NUMA1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
TERF2IP NUMA1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ASPM NUMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3L NUMA1 25348397 N/A physical interaction ComPPI
KATNB1 NUMA1 24234451 25348397 26929214 association tandem affinity purification ComPPI,IntAct
GNAI1 NUMA1 15537540 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct
IFI16 NUMA1 25348397 N/A physical interaction ComPPI
SRRM1 NUMA1 25348397 N/A physical interaction ComPPI
RRP1B NUMA1 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SUZ12 NUMA1 25348397 N/A physical interaction ComPPI
MED19 NUMA1 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TCP10L NUMA1 25348397 N/A physical interaction ComPPI
BRCC3 NUMA1 25348397 N/A physical interaction ComPPI
EMILIN1 NUMA1 25348397 N/A physical interaction ComPPI
GPSM1 NUMA1 25348397 N/A physical interaction ComPPI
NUMA1 EPB41 10189366 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NUMA1 RPAP1 25348397 N/A physical interaction ComPPI
NUMA1 SMARCAD1 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
NUMA1 SIRT7 25348397 N/A physical interaction ComPPI
NUMA1 HSP90AA2P 25348397 N/A physical interaction ComPPI
NUMA1 CBX6 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NUMA1 PCLAF 25348397 N/A physical interaction ComPPI
NUMA1 CCDC57 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NUMA1 ERG 25348397 N/A physical interaction ComPPI
NUMA1 LGR4 25348397 N/A physical interaction ComPPI
NUMA1 BRAP 24234451 25348397 25820252 physical association two hybrid,physical interaction ComPPI,IntAct
NUMA1 DVL1P1 25348397 N/A physical interaction ComPPI
NUMA1 GMCL2 25348397 N/A physical interaction ComPPI
NUMA1 MOV10 25348397 N/A physical interaction ComPPI
NUMA1 NXF1 25348397 N/A physical interaction ComPPI
NUMA1 OBSL1 25348397 N/A physical interaction ComPPI
NUMA1 CCDC8 25348397 N/A physical interaction ComPPI
NUMA1 RPL35A 25348397 N/A physical interaction ComPPI
NUMA1 RTF1 25348397 N/A physical interaction ComPPI
NUMA1 ZC3H18 25348397 N/A physical interaction ComPPI
NUMA1 MATR3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUMA1 TENT4B 25348397 N/A physical interaction ComPPI
NUMA1 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
NUMA1 LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NUMA1 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
NUMA1 WRAP73 24234451 25348397 26545777 association anti tag coimmunoprecipitation ComPPI,IntAct
NUMA1 KATNAL2 24234451 25348397 26929214 association tandem affinity purification ComPPI,IntAct
NUMA1 GPATCH1 24234451 30021884 physical association cross-linking study IntAct
NPR2 NUMA1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 MMEL1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 RIBC1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 DMBX1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 TLN1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 VPS4B 24234451 30021884 physical association cross-linking study IntAct
NUMA1 LYPLA2 24234451 30021884 physical association cross-linking study IntAct
NUMA1 HELZ2 24234451 30021884 physical association cross-linking study IntAct
NUMA1 EIF5B 24234451 30021884 physical association cross-linking study IntAct
NUMA1 LRPAP1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 LRRFIP1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 DDX10 24234451 30021884 physical association cross-linking study IntAct
NUMA1 BIRC6 24234451 30021884 physical association cross-linking study IntAct
KRT4 NUMA1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 SDR42E2 24234451 30021884 physical association cross-linking study IntAct
ZFYVE27 NUMA1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 MACF1 24234451 30021884 physical association cross-linking study IntAct
NUMA1 MLYCD 24234451 30021884 physical association cross-linking study IntAct
NUMA1 GOLGA6L2 24234451 30021884 physical association cross-linking study IntAct
NUMA1 TUBB 11956313 27898060 stimulant N/A OmniPath
CASP3 NUMA1 17401638 27898060 9463409 inhibition,stimulant N/A OmniPath
AURKA NUMA1 23097092 27898060 N/A N/A OmniPath
ABL1 NUMA1 22252550 27898060 N/A N/A OmniPath
CDK1 NUMA1 23921553 27898060 inhibition N/A OmniPath
CASP6 NUMA1 17401638 27898060 9463409 inhibition,stimulant N/A OmniPath
NUMA1 TUBB4B 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBA3C 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBA1C 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBA1B 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBB2A 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBA4A 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBB4A 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBA1A 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBG1 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBA3E 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBD1 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBB6 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBB3 11956313 27898060 stimulant N/A OmniPath
NUMA1 TUBA8 11956313 27898060 stimulant N/A OmniPath

Visualization










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