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GENE：MAP3K1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K1
FullNmae mitogen-activated protein kinase kinase kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6848
EnsembleID ENSG00000095015
Uniprot Q13233

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K1 apoptosis 37014133 Overexpression of MAP3K1 significantly promoted the proliferation of HFSCs by inhibiting apoptosis and promoting the transition from S phase to G2 phase. retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K1 GO:0000165,GO:0004672,GO:0004674,GO:0004674,GO:0004709,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0008270,GO:0019901,GO:0038095,GO:0071260,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K1 hsa:4214 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP3K1 hsa:4214 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
MAP3K1 hsa:4214 path:hsa04530 Tight junction - Homo sapiens (human)
MAP3K1 hsa:4214 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
MAP3K1 hsa:4214 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
MAP3K1 hsa:4214 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
MAP3K1 hsa:4214 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
MAP3K1 hsa:4214 path:hsa05161 Hepatitis B - Homo sapiens (human)
MAP3K1 hsa:4214 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GRB2 MAP3K1 10086337 10465784 10567412 10811803 10982827 11274345 11447289 11668179 11777939 12040186 12048245 12175651 12419216 12640133 12738796 12782630 14585353 15170913 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17496911 17673906 18855897 19449109 19568798 19615955 21102635 21614932 24027568 26192618 26552706 7510700 8551221 9379049 9582321 interaction type N/A ACSN
MAP3K1 TNFRSF1B 10465784 11274345 11668179 12048245 12738796 15170913 15592525 17462996 17496911 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 9379049 9582321 interaction type N/A ACSN
TRAF2 MAP3K1 10465784 11274345 11668179 12048245 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 9379049 9582321 interaction type N/A ACSN
RIPK1 MAP3K1 10465784 11274345 11668179 12048245 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 9379049 9582321 interaction type N/A ACSN
TNFRSF1A MAP3K1 10465784 11274345 11668179 12048245 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 9379049 9582321 interaction type N/A ACSN
TRADD MAP3K1 10465784 11274345 11668179 12048245 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 9379049 9582321 interaction type N/A ACSN
MAP3K1 MAP2K4 10086337 10465784 10567412 10811803 10982827 11242034 11274345 11447289 11668179 11777939 12040186 12048245 12175651 12419216 12456688 12640133 12738796 12782630 14585353 15170913 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17496911 17673906 18182252 18855897 19449109 19568798 19615955 21102635 21614932 23180781 23331499 24027568 26192618 26552706 7510700 8551221 9379049 9582321 interaction type,phosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,in-gel kinase assay ACSN,InnateDB,SignaLink,SignaLink
MAP3K1 MAP2K7 10465784 11242034 11274345 11668179 12048245 12738796 15170913 15592525 17462996 17496911 18641653 18855897 19392652 21133840 21232017 21614932 23331499 23850759 24378531 26192618 9379049 9582321 interaction type,stimulation N/A ACSN,SignaLink
PRKD1 MAP3K1 17496911 17703233 26192618 interaction type N/A ACSN
ECSIT MAP3K1 10465784 25371197 26192618 interaction type N/A ACSN
IKBKB MAP3K1 23180781 9819420 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
MAP2K1 MAP3K1 10969079 12456688 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
MAP3K1 MAP4K1 23180781 8824585 phosphorylation reaction protein kinase assay InnateDB
MAP3K1 CHUK 10713178 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP3K1 PAK1 12228228 23180781 phosphorylation reaction protein kinase assay InnateDB
MAPK1 MAP3K1 10969079 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 MAP3K1 10969079 23180781 physical association anti tag coimmunoprecipitation InnateDB
CHUK MAP3K1 18182252 23180781 physical association anti tag coimmunoprecipitation InnateDB
PKD1 MAP3K1 20923779 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K1 MAP3K1 17563747 26467481 9712898 phosphorylation reaction,up-regulates,up-regulates activity N/A Signor
AXIN1 MAP3K1 10575011 10829020 11884395 21071413 23331499 stimulation N/A SignaLink,SignaLink
MAP3K1 MAPK3 12049732 23331499 stimulation N/A SignaLink,SignaLink
MAP3K1 ZFP36 21921033 phosphorylation reaction,stimulation N/A SignaLink
MAP4K2 MAP3K1 23331499 7515885 stimulation N/A SignaLink
KRAS MAP3K1 23331499 8649450 stimulation N/A SignaLink
MAP4K4 MAP3K1 23331499 8824585 stimulation N/A SignaLink
MAP4K1 MAP3K1 23331499 9003777 stimulation N/A SignaLink
MAP4K5 MAP3K1 23331499 9405407 stimulation N/A SignaLink
MAP3K1 SMAD2 10085121 23331499 stimulation N/A SignaLink
MAPK8IP3 MAP3K1 10523642 23331499 stimulation N/A SignaLink
MAP4K3 MAP3K1 11316611 23331499 stimulation N/A SignaLink
MAP3K1 MAPK1 10969079 12049732 23331499 stimulation N/A SignaLink
SMAD7 MAP3K1 10085121 23331499 inhibition N/A SignaLink
MAP3K1 MAP2K2 15032589 23109003 chemical activation reaction N/A SignaLink
CDC42 MAP3K1 17161586 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AXIN1 MAP3K1 20005715 interaction type N/A PSP,SignaLink
DVL2 MAP3K1 20005715 interaction type N/A PSP
GRB2 MAP3K1 20005715 interaction type N/A PSP,SignaLink
IRS4 MAP3K1 20005715 interaction type N/A PSP,SignaLink
MAPK8IP3 MAP3K1 20005715 interaction type N/A PSP,SignaLink
RPS6 MAP3K1 20005715 interaction type N/A PSP,SignaLink
TRAF2 MAP3K1 20005715 interaction type N/A PSP
YWHAE MAP3K1 20005715 interaction type N/A PSP,SignaLink
DVL2 MAP3K1 10829020 20005715 21071413 N/A N/A SignaLink
TRAF2 MAP3K1 10346818 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAP3K1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MAP3K1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 MAP3K1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MAP3K1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 MAP3K1 9710625 trascriptional regulation,stimulation inferred by curator TFlink
JUN MAP3K1 9710625 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 MAP3K1 16822819 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D MAP3K1 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00000BE495 MAP3K1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001F0C23 MAP3K1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000029979D MAP3K1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 MAP3K1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000367985 MAP3K1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 MAP3K1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 MAP3K1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00003E6EFA MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000018E72A MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 MAP3K1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 MAP3K1 25416803 26842910 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000346991 MAP3K1 25416803 26842910 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000027080C MAP3K1 25416803 26842910 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000041E949 MAP3K1 25416803 26842910 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002E857A MAP3K1 25416803 26019450 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PAK1 MAP3K1 22135298 phosphorylation N/A PhosphoSite
MAP3K1 MAP2K7 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP3K1 NOTCH1 22135298 phosphorylation N/A PhosphoSite
MAP3K1 MAFA 22135298 phosphorylation N/A PhosphoSite
MAP3K1 FADD 22135298 phosphorylation N/A PhosphoSite
RAF1 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 RAF1 25361965 interaction type N/A PTMCode2
MAP4K3 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP4K3 25361965 interaction type N/A PTMCode2
DVL2 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 DVL2 25361965 interaction type N/A PTMCode2
BRAF MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 BRAF 25361965 interaction type N/A PTMCode2
MAPK10 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAPK10 25361965 interaction type N/A PTMCode2
AXIN1 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 AXIN1 25361965 interaction type N/A PTMCode2
MAP2K1 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP2K1 25361965 interaction type N/A PTMCode2
CHUK MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 CHUK 25361965 interaction type N/A PTMCode2
GRB2 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 GRB2 25361965 interaction type N/A PTMCode2
MAP2K7 MAP3K1 25361965 interaction type N/A PTMCode2
MAP4K2 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP4K2 25361965 interaction type N/A PTMCode2
GRIPAP1 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 GRIPAP1 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP2K4 25361965 interaction type N/A PTMCode2
MAP4K4 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP4K4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I MAP3K1 25348397 N/A physical interaction ComPPI
MAPK9 MAP3K1 25348397 N/A physical interaction ComPPI
HSPA8 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBASH3B MAP3K1 25348397 N/A physical interaction ComPPI
VIM MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSPBP1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ACTG1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SNRPF MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TUBB MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPL37A MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
GSTP1 MAP3K1 25348397 N/A physical interaction ComPPI
YWHAG MAP3K1 25348397 N/A physical interaction ComPPI
CALM1 MAP3K1 25348397 N/A tandem affinity purification ComPPI
UBE2D1 MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DCUN1D1 MAP3K1 25348397 N/A physical interaction ComPPI
MCM2 MAP3K1 25348397 N/A physical interaction ComPPI
TNIP1 MAP3K1 25348397 N/A physical interaction ComPPI
SLC25A6 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSP90AB1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBE2D4 MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RPL10A MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
GGA2 MAP3K1 25348397 N/A physical interaction ComPPI
APPL1 MAP3K1 25348397 N/A physical interaction ComPPI
H4C1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PAK1 MAP3K1 25348397 N/A physical interaction ComPPI
MAPK1 MAP3K1 10969079 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RPL10 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAPK8 MAP3K1 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
NOTCH1 MAP3K1 25348397 N/A physical interaction ComPPI
MAP4K2 MAP3K1 11784851 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK3 MAP3K1 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
GRB2 MAP3K1 25348397 N/A physical interaction ComPPI
JUN MAP3K1 25348397 N/A physical interaction ComPPI
DHX9 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBE2G1 MAP3K1 25348397 N/A physical interaction ComPPI
UBE2D2 MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RHOA MAP3K1 14581471 21129722 24135036 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FLNA MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SPART MAP3K1 25348397 N/A physical interaction ComPPI
GSK3B MAP3K1 25348397 N/A physical interaction ComPPI
MAP4K4 MAP3K1 25348397 N/A physical interaction ComPPI
IRS4 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HGS MAP3K1 25348397 N/A physical interaction ComPPI
UBB MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBC MAP3K1 16845370 24234451 25348397 physical association pull down ComPPI,IntAct
HSP90AA1 MAP3K1 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
ACTN1 MAP3K1 25348397 N/A physical interaction ComPPI
NTRK1 MAP3K1 25348397 N/A physical interaction ComPPI
AXIN1 MAP3K1 22682247 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K4 MAP3K1 24234451 25348397 9808624 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,physical interaction,protein kinase assay ComPPI,IntAct
HSPA5 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
APEX2 MAP3K1 25348397 N/A physical interaction ComPPI
IKBKB MAP3K1 16286467 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
MAP2K1 MAP3K1 17110930 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYC MAP3K1 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MAPK8IP3 MAP3K1 25348397 N/A physical interaction ComPPI
DNAJA3 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DNAJB2 MAP3K1 25348397 N/A physical interaction ComPPI
NFKBIA MAP3K1 25348397 N/A physical interaction ComPPI
STAM2 MAP3K1 25348397 N/A physical interaction ComPPI
DYRK1B MAP3K1 20940704 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAD MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
STK38 MAP3K1 25348397 N/A physical interaction ComPPI
RAD18 MAP3K1 25348397 N/A physical interaction ComPPI
RAB3IL1 MAP3K1 25348397 N/A physical interaction ComPPI
EPHA1 MAP3K1 25348397 N/A physical interaction ComPPI
UBAC1 MAP3K1 25348397 N/A physical interaction ComPPI
RAD51AP1 MAP3K1 25348397 N/A physical interaction ComPPI
XPO1 MAP3K1 25348397 N/A physical interaction ComPPI
YWHAQ MAP3K1 25348397 N/A physical interaction ComPPI
TRAF2 MAP3K1 16636664 24234451 25241761 25348397 physical association anti tag coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
ARRB1 MAP3K1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS6 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RAD23A MAP3K1 25348397 N/A physical interaction ComPPI
RPS13 MAP3K1 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
EPN1 MAP3K1 25348397 N/A physical interaction ComPPI
RPL4 MAP3K1 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
TOM1L2 MAP3K1 25348397 N/A physical interaction ComPPI
RPLP2 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DVL2 MAP3K1 25348397 N/A physical interaction ComPPI
ARRB2 MAP3K1 17620599 24234451 25241761 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
ODF2 MAP3K1 25348397 N/A physical interaction ComPPI
TUBA1A MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
YWHAE MAP3K1 14743216 24234451 25348397 9452471 colocalization,physical association coimmunoprecipitation,physical interaction,imaging technique,tandem affinity purification ComPPI,IntAct
NR4A1 MAP3K1 25348397 N/A physical interaction ComPPI
MBP MAP3K1 25348397 N/A physical interaction ComPPI
TCP1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CCT5 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RAF1 MAP3K1 10969079 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HIPK2 MAP3K1 20940704 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DTX1 MAP3K1 25348397 N/A physical interaction ComPPI
HSPH1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CHUK MAP3K1 25348397 N/A physical interaction ComPPI
HSPA9 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBE2K MAP3K1 25348397 N/A physical interaction ComPPI
ATXN3 MAP3K1 25348397 N/A physical interaction ComPPI
RPL7 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FLNB MAP3K1 19270716 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
SSR4 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PSMD4 MAP3K1 25348397 N/A physical interaction ComPPI
STAM MAP3K1 25348397 N/A physical interaction ComPPI
GRIPAP1 MAP3K1 25348397 N/A physical interaction ComPPI
UBE2D3 MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDC37 MAP3K1 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
MAP2K7 MAP3K1 17110930 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MARS1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBE2L6 MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBQLN1 MAP3K1 25348397 N/A physical interaction ComPPI
TUBB4A MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NOP56 MAP3K1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDB1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HIP1 MAP3K1 25348397 N/A physical interaction ComPPI
ESR1 MAP3K1 15556606 24234451 25348397 phosphorylation reaction coimmunoprecipitation ComPPI,IntAct
BRAF MAP3K1 16810323 16888650 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,protein kinase assay ComPPI,IntAct
FRAT1 MAP3K1 25348397 N/A physical interaction ComPPI
BRCA1 MAP3K1 25348397 N/A physical interaction ComPPI
PLEKHB2 MAP3K1 25348397 N/A physical interaction ComPPI
GLUD1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBE2E1 MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BAP1 MAP3K1 25348397 N/A physical interaction ComPPI
RPL13 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBE2V1 MAP3K1 25348397 N/A physical interaction ComPPI
DNAJA1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DNAJB6 MAP3K1 25348397 N/A physical interaction ComPPI
CARD14 MAP3K1 25348397 N/A physical interaction ComPPI
RPS9 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
BAG2 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FAF2 MAP3K1 25348397 N/A physical interaction ComPPI
ASCC2 MAP3K1 25348397 N/A physical interaction ComPPI
HNRNPM MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DCAF7 MAP3K1 14743216 20940704 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy,tandem affinity purification ComPPI,IntAct
RPL14 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
DYRK1A MAP3K1 20940704 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NPLOC4 MAP3K1 25348397 N/A physical interaction ComPPI
UFD1 MAP3K1 25348397 N/A physical interaction ComPPI
TRIM5 MAP3K1 25348397 N/A physical interaction ComPPI
RUVBL2 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UCHL5 MAP3K1 25348397 N/A physical interaction ComPPI
TIMM50 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CD74 MAP3K1 25348397 N/A physical interaction ComPPI
RNF141 MAP3K1 25348397 N/A physical interaction ComPPI
ZFAND5 MAP3K1 25348397 N/A physical interaction ComPPI
RPL24 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
KAT5 MAP3K1 25348397 N/A physical interaction ComPPI
CRELD1 MAP3K1 25348397 N/A physical interaction ComPPI
ALK MAP3K1 25348397 N/A physical interaction ComPPI
EEF1A2 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RCN2 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SLC25A5 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPS14 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
FASN MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
LGALS3BP MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RNF126 MAP3K1 25348397 N/A physical interaction ComPPI
FKBP6 MAP3K1 25348397 N/A physical interaction ComPPI
BAALC MAP3K1 25348397 N/A physical interaction ComPPI
RPL30 MAP3K1 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
RPS11 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
AIFM1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CCT4 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CRTC1 MAP3K1 25348397 N/A physical interaction ComPPI
MYH10 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RBCK1 MAP3K1 25348397 N/A physical interaction ComPPI
CCT6A MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPS4X MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPL35A MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPS27 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
UBE2W MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ZFAND3 MAP3K1 25348397 N/A physical interaction ComPPI
RNF114 MAP3K1 25348397 N/A physical interaction ComPPI
MINDY3 MAP3K1 25348397 N/A physical interaction ComPPI
RPL3 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RPS16 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
USP28 MAP3K1 25348397 N/A physical interaction ComPPI
MAP3K1 FKBP5 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
MAP3K1 ARHGAP4 25348397 N/A physical interaction ComPPI
MAP3K1 TP53 20923779 25348397 26018553 27898060 N/A physical interaction ComPPI,OmniPath
MAP3K1 CUEDC1 25348397 N/A physical interaction ComPPI
MAP3K1 HBS1L 25348397 N/A physical interaction ComPPI
MAP3K1 TOM1 25348397 N/A physical interaction ComPPI
MAP3K1 UBXN7 25348397 N/A physical interaction ComPPI
MAP3K1 ILRUN 25348397 N/A physical interaction ComPPI
MAP3K1 TAB1 25348397 N/A physical interaction ComPPI
MAP3K1 UBAP1 25348397 N/A physical interaction ComPPI
MAP3K1 NEK10 25348397 N/A physical interaction ComPPI
MAP3K1 IMPACT 25348397 N/A physical interaction ComPPI
MAP3K1 DCUN1D2 25348397 N/A physical interaction ComPPI
MAP3K1 CEP85 25348397 N/A physical interaction ComPPI
MAP3K1 FAM184A 25348397 N/A physical interaction ComPPI
MAP3K1 KRT36 25348397 N/A physical interaction ComPPI
MAP3K1 DENND6B 25348397 N/A physical interaction ComPPI
MAP3K1 CCDC69 25348397 N/A physical interaction ComPPI
MAP3K1 RABEP2 25348397 N/A physical interaction ComPPI
MAP3K1 LLGL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K1 HSPA1L 14743216 24234451 25241761 25348397 physical association physical interaction,tandem affinity purification,proximity ligation assay ComPPI,IntAct
MAP3K1 CCT8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 RPS27L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 EPPK1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 HSPA6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 SLC1A5 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 HADHB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 CCT3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 GEMIN4 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 TUBB2B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 HADHA 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 TUBB6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 TUBB8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 RPLP0P6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 RPL18 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 RPS8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 NOP2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 NCL 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 RPS23 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 RPL35 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 TUBA3C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 USP9X 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 MYLK2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 MYO1D 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
BAG5 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K1 MAP3K1 14743216 24234451 physical association tandem affinity purification IntAct
CALM2 MAP3K1 14743216 24234451 physical association tandem affinity purification IntAct
CHRM5 MAP3K1 24234451 28298427 physical association ubiquitin reconstruction IntAct
HNRNPK MAP3K1 24234451 30021884 physical association cross-linking study IntAct
CHUK MAP3K1 10713178 16286467 18182252 27898060 9689078 9819420 N/A N/A OmniPath
MAP3K1 CHUK 10713178 16286467 18182252 27898060 9689078 9819420 stimulant N/A OmniPath
TRAF2 MAP3K1 10346818 16636664 18635759 25241761 25260751 27898060 stimulant N/A OmniPath
MAP3K1 FADD 15001534 27898060 inhibition N/A OmniPath
MAP2K1 MAP3K1 10969079 12456688 14500727 17110930 18982020 27898060 9804171 9878570 N/A N/A OmniPath
MAP3K1 MAP2K1 10969079 12456688 14500727 17110930 18982020 27898060 9804171 9878570 stimulant N/A OmniPath
MAP3K14 MAP3K1 27898060 9135144 stimulant N/A OmniPath
STK38 MAP3K1 17906693 27898060 inhibition N/A OmniPath
MAP2K4 MAP3K1 10713157 11274345 12228228 12456688 12738796 14500727 14581471 15299005 15866172 16472679 18182252 18855897 21614932 27898060 9712898 9808624 N/A N/A OmniPath
MAP3K1 MAP2K4 10713157 11274345 12228228 12456688 12738796 14500727 14581471 15299005 15866172 16472679 18182252 18855897 21614932 27898060 9712898 9808624 stimulant N/A OmniPath
MAP3K1 MAPK3 12049732 24135036 25241761 27898060 stimulant N/A OmniPath
ABL1 MAP3K1 10866655 20841568 27898060 stimulant N/A OmniPath
MAP3K1 RAF1 10969079 27898060 N/A N/A OmniPath
MAP3K1 SMAD2 10085121 27898060 stimulant N/A OmniPath
MAP3K1 MAP2K6 27898060 9712898 stimulant N/A OmniPath
MAP3K1 MAPK1 10969079 1096908 12049732 14500727 14581471 24135036 27898060 stimulant N/A OmniPath
PAK1 MAP3K1 12228228 27898060 stimulant N/A OmniPath
AXIN1 MAP3K1 10575011 10829020 11408485 11884395 12878610 20128690 24135036 27898060 stimulant N/A OmniPath
RIPK1 MAP3K1 11369754 27898060 stimulant N/A OmniPath
CDC42 MAP3K1 27898060 7601337 9305638 stimulant N/A OmniPath
GSK3B MAP3K1 12584189 27898060 stimulant N/A OmniPath
MAP3K1 MAP2K7 11242034 12947395 14500727 15866172 17110930 18635759 27898060 9312068 stimulant N/A OmniPath
MAP3K1 STAT3 17563747 27898060 stimulant N/A OmniPath
MAP3K1 MAPK8 10465784 12228228 14500727 15299005 21152872 25241761 27898060 9405400 stimulant N/A OmniPath
IKBKB MAP3K1 11057907 16286467 27898060 9819420 N/A N/A OmniPath
MAP3K1 IKBKB 11057907 16285893 16286467 27898060 9008162 9520401 9689078 9819420 stimulant N/A OmniPath
SMAD7 MAP3K1 10085121 27898060 inhibition N/A OmniPath
MAP3K1 EPHA4 27898060 7997270 stimulant N/A OmniPath
MAP4K2 MAP3K1 11784851 27898060 7515885 9712898 stimulant N/A OmniPath
ECSIT MAP3K1 10465784 27898060 stimulant N/A OmniPath
MAPK8IP3 MAP3K1 10523642 27898060 stimulant N/A OmniPath
KRAS MAP3K1 12228228 27898060 7744823 8649450 stimulant N/A OmniPath
MAP4K4 MAP3K1 27898060 8824585 stimulant N/A OmniPath
MAP4K1 MAP3K1 27898060 8824585 stimulant N/A OmniPath
MAP4K3 MAP3K1 27898060 9820741 stimulant N/A OmniPath
MAP3K1 MAFA 23660596 27898060 N/A N/A OmniPath
MAP3K1 CRTC1 18784253 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B03C6 MAP3K1 27087310 direct interaction,inhibition N/A NPInter

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