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GENE：ID4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ID4
FullNmae inhibitor of DNA binding 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5363
EnsembleID ENSG00000172201
Uniprot P47928

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ID4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ID4 apoptosis 24330748 Ectopic expression of Id4 in DU145 cells resulted in increased apoptosis and expression of BAX, PUMA and p21, the transcriptional targets of p53. retulator signature

Go Annotation:

GeneSymbol Go id
ID4 GO:0000082,GO:0000122,GO:0000122,GO:0001649,GO:0002052,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0007405,GO:0008104,GO:0010628,GO:0021766,GO:0021895,GO:0022010,GO:0030154,GO:0032922,GO:0045444,GO:0045599,GO:0045665,GO:0045892,GO:0045944,GO:0046983,GO:0048708,GO:0048712,GO:0048715,GO:0060740,GO:0060741,GO:0061629,GO:0061682,GO:0140110,GO:0140416

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ID4 hsa:3400 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
ID4 hsa:3400 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LYL1 ID4 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLCG1 ID4 17474147 23180781 physical association peptide array InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 ID4 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 ID4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ID4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 ID4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ID4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ID4 9516472 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ID4 9516472 trascriptional regulation,stimulation inferred by curator TFlink
SP3 ID4 9516472 trascriptional regulation,stimulation inferred by curator TFlink
USF1 ID4 9516472 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ID4 21618216 rna interference,inhibition experimental interaction detection,western blot miRSponge
URS0000272039 ID4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS0000237AF9 ID4 20371350 21618216 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,clip TarBase
URS0000007FBA ID4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000B59A2 ID4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00001B341F ID4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000005481D ID4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 ID4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000148B91 ID4 24475217 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000939AF ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB ID4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 ID4 20371350 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 ID4 20371350 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000A057E ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 ID4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 ID4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5659 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 ID4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E ID4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 ID4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 ID4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 ID4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE ID4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000039D790 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004505E4 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 ID4 20371350 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F ID4 20371350 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C ID4 20371350 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 ID4 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075BC91 ID4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 ID4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000105D19 ID4 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MYOD1 ID4 25361965 interaction type N/A PTMCode2
ID4 MYOD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MYOG ID4 25348397 N/A physical interaction ComPPI
CRK ID4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
MYOD1 ID4 11756408 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PIK3R1 ID4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
SRC ID4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NCK1 ID4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 ID4 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
ID3 ID4 14525934 25348397 8759016 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
ID4 HES1 11756408 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ID4 TCF3 25348397 N/A physical interaction ComPPI
ID4 TCF4 11756408 14525934 24234451 25348397 25609649 association physical interaction,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
ID4 METTL2A 25348397 N/A physical interaction ComPPI
ID4 ID2 25348397 N/A physical interaction ComPPI
ID4 MYF6 25348397 N/A physical interaction ComPPI
ID4 PLCG1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NEUROG3 ID4 25348397 N/A physical interaction ComPPI

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