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GENE：LIMK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LIMK1
FullNmae LIM domain kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6613
EnsembleID ENSG00000106683
Uniprot P53667

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LIMK1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LIMK1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LIMK1 GO:0001673,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0005925,GO:0006468,GO:0006468,GO:0007165,GO:0007266,GO:0007399,GO:0016020,GO:0016607,GO:0030027,GO:0030036,GO:0031072,GO:0032233,GO:0038096,GO:0043005,GO:0043005,GO:0043149,GO:0045773,GO:0046872,GO:0048675,GO:0051444,GO:0051496,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LIMK1 hsa:3984 path:hsa04360 Axon guidance - Homo sapiens (human)
LIMK1 hsa:3984 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
LIMK1 hsa:3984 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
LIMK1 hsa:3984 path:hsa05135 Yersinia infection - Homo sapiens (human)
LIMK1 hsa:3984 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ROCK1 LIMK1 10652353 11698448 12194823 12778124 19349987 26192618 27785353 interaction type N/A ACSN
CDC42BPA LIMK1 10461188 10559936 10613909 11018042 11340065 11413130 11950587 17522712 22154077 26192618 interaction type N/A ACSN
PAK1 LIMK1 10461188 10467124 10511705 10559936 10613909 10661401 11018042 11062502 11121431 11340065 11385609 11413130 11907067 11950587 12054568 12885870 14749719 14764585 15157156 15229651 15536084 15713627 16293614 16702231 17522712 22154077 26192618 8625410 9843499 interaction type N/A ACSN
PAK4 LIMK1 10461188 10559936 10613909 11018042 11340065 11413130 11950587 17522712 22154077 26192618 interaction type N/A ACSN
LIMK1 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRPK1 LIMK1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB
LIMK1 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CDKN1C LIMK1 20005715 interaction type N/A PSP
CFL1 LIMK1 20005715 interaction type N/A PSP
PXN LIMK1 20005715 interaction type N/A PSP
YWHAZ LIMK1 20005715 interaction type N/A PSP
YWHAZ LIMK1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 LIMK1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 LIMK1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR LIMK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 LIMK1 17242205 25416803 27292025 mrna cleavage,inhibition array technology,clip TarBase
URS0000134ADC LIMK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F LIMK1 24858712 25416803 27292025 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002075FA LIMK1 23029228 25416803 27292025 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002B3783 LIMK1 23029228 25416803 27292025 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000039E1E1 LIMK1 23029228 25416803 27292025 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000008A99 LIMK1 25003638 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000009A9A2 LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019907A LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000137EDE LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000170D8B LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004AD450 LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000247AC6 LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F9738 LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005DEC41 LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075ABF4 LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041FA2C LIMK1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003883FE LIMK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000037D7E5 LIMK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000298BA3 LIMK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000021D08 LIMK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000039607D LIMK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000DDD35 LIMK1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPKAPK2 LIMK1 22135298 phosphorylation N/A PhosphoSite
PAK4 LIMK1 22135298 phosphorylation N/A PhosphoSite
MAPK14 LIMK1 22135298 phosphorylation N/A PhosphoSite
ROCK1 LIMK1 22135298 phosphorylation N/A PhosphoSite
LIMK1 CFL1 22135298 phosphorylation N/A PhosphoSite
LIMK1 DSTN 22135298 phosphorylation N/A PhosphoSite
PAK6 LIMK1 22135298 phosphorylation N/A PhosphoSite
PAK1 LIMK1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PAK2 LIMK1 14525934 16837009 24234451 25348397 phosphorylation reaction experimental interaction detection,nuclear magnetic resonance,protein kinase assay,in vitro ComPPI,HPRD,IntAct
CFL1 LIMK1 11340065 11418599 11925442 14525934 16456544 17853892 19424295 20133759 24234451 25348397 9655398 phosphorylation reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
UXT LIMK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROCK1 LIMK1 10436159 10559936 10652353 11340065 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HSP90AB1 LIMK1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
MMP14 LIMK1 21219645 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct,OmniPath
BAD LIMK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDIT4L LIMK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLMH LIMK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK1 LIMK1 10559936 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy,protein kinase assay,in vitro,in vivo ComPPI,IntAct
ERBIN LIMK1 25348397 N/A physical interaction ComPPI
RRAS LIMK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK14 LIMK1 16456544 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
PRKACA LIMK1 19424295 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
YWHAZ LIMK1 12323073 12361576 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
HSP90AA1 LIMK1 25348397 N/A physical interaction ComPPI
CDKN1C LIMK1 14525934 14530263 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PXN LIMK1 25348397 N/A in vivo ComPPI
BMPR2 LIMK1 12963706 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RAD54L LIMK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TADA3 LIMK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARRB1 LIMK1 25348397 N/A physical interaction ComPPI
RLIM LIMK1 10431247 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRPK1 LIMK1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
ARRB2 LIMK1 25348397 N/A physical interaction ComPPI
ITGA1 LIMK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MBP LIMK1 25348397 N/A physical interaction ComPPI
HSPA4 LIMK1 25348397 N/A physical interaction ComPPI
MAPKAPK2 LIMK1 16456544 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
PAK4 LIMK1 11413130 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FYN LIMK1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PRKN LIMK1 25348397 N/A physical interaction ComPPI
LIMK1 CFL2 12684437 14525934 25348397 8824278 9655398 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LIMK1 LIMK2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
LIMK1 CDC42BPA 10559936 10652353 11340065 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
LIMK1 LATS1 14525934 15220930 24234451 25348397 colocalization,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vitro,in vivo ComPPI,HPRD,IntAct
LIMK1 SSH3 14525934 15660133 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
LIMK1 ABCA1 14525934 16192283 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
LIMK1 NRG1 14525934 25348397 9685409 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
LIMK1 ELAVL1 25348397 N/A physical interaction ComPPI
LIMK1 H1-1 25348397 N/A physical interaction ComPPI
LIMK1 APP 25348397 N/A physical interaction ComPPI
LIMK1 HSP90AA2P 25348397 N/A physical interaction ComPPI
LIMK1 BRAF 17979178 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
LIMK1 POLR2D 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK1 RTEL1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK1 LAMTOR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK1 MIIP 25348397 N/A physical interaction ComPPI
LIMK1 OSBPL5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK1 SH3PXD2B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK1 KIF23 25348397 N/A physical interaction ComPPI
LIMK1 HUNK 20133759 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK1 SSH1 15660133 24234451 25348397 dephosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,pull down,imaging technique,phosphatase assay ComPPI,IntAct
LIMK1 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
SARNP LIMK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK1 LIMK1 14525934 17192257 8980133 N/A experimental interaction detection HPRD
LIMK1 RNF6 16204183 27898060 N/A N/A OmniPath
MAPKAPK2 LIMK1 16456544 27898060 stimulant N/A OmniPath
ROCK1 LIMK1 10436159 10559936 10652353 11018042 11340065 11784854 15660133 16641196 18332102 20696146 21693580 25486435 25544611 25714010 27898060 stimulant N/A OmniPath
LIMK1 CFL1 10436159 11340065 11418599 11925442 12361576 12963706 15220930 16278681 16456544 17500066 17853892 18079118 18491316 18578522 18669648 18702456 19413330 19424295 19651622 20058876 20068231 27898060 8079118 9655398 inhibition,stimulant N/A OmniPath
CDC42BPA LIMK1 10559936 10652353 11340065 27898060 stimulant N/A OmniPath
ROCK2 LIMK1 10436159 10652353 27898060 stimulant N/A OmniPath
LIMK1 CFL2 12684437 19413330 19651622 20068231 27898060 8079118 8824278 9655398 inhibition,stimulant N/A OmniPath
LIMK1 IL1R1 27898060 9821957 N/A N/A OmniPath
PAK1 LIMK1 10559936 10652353 11340065 11413130 15660133 27898060 stimulant N/A OmniPath
DAPK1 LIMK1 10652353 27898060 N/A N/A OmniPath
LIMK1 PLD2 15979581 27898060 N/A N/A OmniPath
LIMK1 DLG1 12933808 27898060 N/A N/A OmniPath
SSH1 LIMK1 15660133 27898060 N/A N/A OmniPath

Visualization










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