GENE:LIMK1
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | LIMK1 |
FullNmae | LIM domain kinase 1 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:6613 |
EnsembleID | ENSG00000106683 |
Uniprot | P53667 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
LIMK1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
LIMK1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
LIMK1 | GO:0001673,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0005925,GO:0006468,GO:0006468,GO:0007165,GO:0007266,GO:0007399,GO:0016020,GO:0016607,GO:0030027,GO:0030036,GO:0031072,GO:0032233,GO:0038096,GO:0043005,GO:0043005,GO:0043149,GO:0045773,GO:0046872,GO:0048675,GO:0051444,GO:0051496,GO:0106310 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
LIMK1 | hsa:3984 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
LIMK1 | hsa:3984 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
LIMK1 | hsa:3984 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
LIMK1 | hsa:3984 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
LIMK1 | hsa:3984 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ROCK1 | LIMK1 | 10652353 11698448 12194823 12778124 19349987 26192618 27785353 | interaction type | N/A | ACSN |
CDC42BPA | LIMK1 | 10461188 10559936 10613909 11018042 11340065 11413130 11950587 17522712 22154077 26192618 | interaction type | N/A | ACSN |
PAK1 | LIMK1 | 10461188 10467124 10511705 10559936 10613909 10661401 11018042 11062502 11121431 11340065 11385609 11413130 11907067 11950587 12054568 12885870 14749719 14764585 15157156 15229651 15536084 15713627 16293614 16702231 17522712 22154077 26192618 8625410 9843499 | interaction type | N/A | ACSN |
PAK4 | LIMK1 | 10461188 10559936 10613909 11018042 11340065 11413130 11950587 17522712 22154077 26192618 | interaction type | N/A | ACSN |
LIMK1 | EGR1 | 19032775 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
SRPK1 | LIMK1 | 23180781 23602568 | phosphorylation reaction | protein kinase assay | InnateDB |
LIMK1 | ELAVL1 | 19322201 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ETS1 | LIMK1 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
PRDM14 | LIMK1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
SMARCA4 | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXP1 | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TRIM28 | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
VDR | LIMK1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00000600E6 | LIMK1 | 17242205 25416803 27292025 | mrna cleavage,inhibition | array technology,clip | TarBase |
URS0000134ADC | LIMK1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS0000042E1F | LIMK1 | 24858712 25416803 27292025 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
URS00002075FA | LIMK1 | 23029228 25416803 27292025 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
URS00002B3783 | LIMK1 | 23029228 25416803 27292025 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
URS000039E1E1 | LIMK1 | 23029228 25416803 27292025 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
URS0000008A99 | LIMK1 | 25003638 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
URS000009A9A2 | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000019907A | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS0000137EDE | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS0000170D8B | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00004AD450 | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS0000247AC6 | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00000BF7F9 | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00005F9738 | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000015A0D9 | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00005DEC41 | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000075ABF4 | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000041FA2C | LIMK1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00003883FE | LIMK1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000037D7E5 | LIMK1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000298BA3 | LIMK1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000021D08 | LIMK1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000039607D | LIMK1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS00000DDD35 | LIMK1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
MAPKAPK2 | LIMK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
PAK4 | LIMK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
MAPK14 | LIMK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
ROCK1 | LIMK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
LIMK1 | CFL1 | 22135298 | phosphorylation | N/A | PhosphoSite |
LIMK1 | DSTN | 22135298 | phosphorylation | N/A | PhosphoSite |
PAK6 | LIMK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
PAK1 | LIMK1 | 22135298 | phosphorylation | N/A | PhosphoSite |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
PAK2 | LIMK1 | 14525934 16837009 24234451 25348397 | phosphorylation reaction | experimental interaction detection,nuclear magnetic resonance,protein kinase assay,in vitro | ComPPI,HPRD,IntAct |
CFL1 | LIMK1 | 11340065 11418599 11925442 14525934 16456544 17853892 19424295 20133759 24234451 25348397 9655398 | phosphorylation reaction,physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo | ComPPI,HPRD,IntAct |
UXT | LIMK1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
ROCK1 | LIMK1 | 10436159 10559936 10652353 11340065 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
HSP90AB1 | LIMK1 | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
MMP14 | LIMK1 | 21219645 24234451 25348397 27898060 | colocalization,physical association | anti bait coimmunoprecipitation,fluorescence microscopy | ComPPI,IntAct,OmniPath |
BAD | LIMK1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
DDIT4L | LIMK1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BLMH | LIMK1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PAK1 | LIMK1 | 10559936 24234451 25348397 | phosphorylation reaction,colocalization,physical association | anti bait coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy,protein kinase assay,in vitro,in vivo | ComPPI,IntAct |
ERBIN | LIMK1 | 25348397 | N/A | physical interaction | ComPPI |
RRAS | LIMK1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MAPK14 | LIMK1 | 16456544 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
PRKACA | LIMK1 | 19424295 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
YWHAZ | LIMK1 | 12323073 12361576 14525934 24234451 25348397 | physical association | two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
HSP90AA1 | LIMK1 | 25348397 | N/A | physical interaction | ComPPI |
CDKN1C | LIMK1 | 14525934 14530263 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
PXN | LIMK1 | 25348397 | N/A | in vivo | ComPPI |
BMPR2 | LIMK1 | 12963706 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
RAD54L | LIMK1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
TADA3 | LIMK1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
ARRB1 | LIMK1 | 25348397 | N/A | physical interaction | ComPPI |
RLIM | LIMK1 | 10431247 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
SRPK1 | LIMK1 | 23602568 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
ARRB2 | LIMK1 | 25348397 | N/A | physical interaction | ComPPI |
ITGA1 | LIMK1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MBP | LIMK1 | 25348397 | N/A | physical interaction | ComPPI |
HSPA4 | LIMK1 | 25348397 | N/A | physical interaction | ComPPI |
MAPKAPK2 | LIMK1 | 16456544 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
PAK4 | LIMK1 | 11413130 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
FYN | LIMK1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
PRKN | LIMK1 | 25348397 | N/A | physical interaction | ComPPI |
LIMK1 | CFL2 | 12684437 14525934 25348397 8824278 9655398 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
LIMK1 | LIMK2 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
LIMK1 | CDC42BPA | 10559936 10652353 11340065 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
LIMK1 | LATS1 | 14525934 15220930 24234451 25348397 | colocalization,physical association | coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vitro,in vivo | ComPPI,HPRD,IntAct |
LIMK1 | SSH3 | 14525934 15660133 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
LIMK1 | ABCA1 | 14525934 16192283 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
LIMK1 | NRG1 | 14525934 25348397 9685409 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
LIMK1 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
LIMK1 | H1-1 | 25348397 | N/A | physical interaction | ComPPI |
LIMK1 | APP | 25348397 | N/A | physical interaction | ComPPI |
LIMK1 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
LIMK1 | BRAF | 17979178 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
LIMK1 | POLR2D | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
LIMK1 | RTEL1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
LIMK1 | LAMTOR1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
LIMK1 | MIIP | 25348397 | N/A | physical interaction | ComPPI |
LIMK1 | OSBPL5 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
LIMK1 | SH3PXD2B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
LIMK1 | KIF23 | 25348397 | N/A | physical interaction | ComPPI |
LIMK1 | HUNK | 20133759 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
LIMK1 | SSH1 | 15660133 24234451 25348397 | dephosphorylation reaction,colocalization,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,pull down,imaging technique,phosphatase assay | ComPPI,IntAct |
LIMK1 | MFHAS1 | 24234451 25348397 29513927 | N/A | protein array | ComPPI,IntAct |
SARNP | LIMK1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
LIMK1 | LIMK1 | 14525934 17192257 8980133 | N/A | experimental interaction detection | HPRD |
LIMK1 | RNF6 | 16204183 27898060 | N/A | N/A | OmniPath |
MAPKAPK2 | LIMK1 | 16456544 27898060 | stimulant | N/A | OmniPath |
ROCK1 | LIMK1 | 10436159 10559936 10652353 11018042 11340065 11784854 15660133 16641196 18332102 20696146 21693580 25486435 25544611 25714010 27898060 | stimulant | N/A | OmniPath |
LIMK1 | CFL1 | 10436159 11340065 11418599 11925442 12361576 12963706 15220930 16278681 16456544 17500066 17853892 18079118 18491316 18578522 18669648 18702456 19413330 19424295 19651622 20058876 20068231 27898060 8079118 9655398 | inhibition,stimulant | N/A | OmniPath |
CDC42BPA | LIMK1 | 10559936 10652353 11340065 27898060 | stimulant | N/A | OmniPath |
ROCK2 | LIMK1 | 10436159 10652353 27898060 | stimulant | N/A | OmniPath |
LIMK1 | CFL2 | 12684437 19413330 19651622 20068231 27898060 8079118 8824278 9655398 | inhibition,stimulant | N/A | OmniPath |
LIMK1 | IL1R1 | 27898060 9821957 | N/A | N/A | OmniPath |
PAK1 | LIMK1 | 10559936 10652353 11340065 11413130 15660133 27898060 | stimulant | N/A | OmniPath |
DAPK1 | LIMK1 | 10652353 27898060 | N/A | N/A | OmniPath |
LIMK1 | PLD2 | 15979581 27898060 | N/A | N/A | OmniPath |
LIMK1 | DLG1 | 12933808 27898060 | N/A | N/A | OmniPath |
SSH1 | LIMK1 | 15660133 27898060 | N/A | N/A | OmniPath |