Gene Information gene info

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GENE：DIABLO

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DIABLO
FullNmae diablo IAP-binding mitochondrial protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21528
EnsembleID ENSG00000184047
Uniprot Q9NR28

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DIABLO necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DIABLO immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DIABLO apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DIABLO apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DIABLO GO:0005515,GO:0005739,GO:0005739,GO:0005758,GO:0005829,GO:0006915,GO:0006919,GO:0008625,GO:0008631,GO:0008635,GO:0008635,GO:0009898,GO:0035631,GO:0043065,GO:0051402,GO:0097193

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DIABLO hsa:56616 path:hsa04210 Apoptosis - Homo sapiens (human)
DIABLO hsa:56616 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
XIAP DIABLO 10929711 11140637 11157976 15078891 17435549 22733138 23070005 23180781 26192618 26587781 association,physical association anti tag coimmunoprecipitation ACSN,InnateDB
BIRC5 DIABLO 12660240 12925766 15249581 16571674 17956729 26192618 association N/A ACSN
BIRC6 DIABLO 14765125 15200957 15300255 15507451 15781261 23180781 26192618 interaction type,ubiquitination reaction,physical association anti tag coimmunoprecipitation,ubiquitination reaction ACSN,InnateDB
DIABLO XIAP 11157976 11242052 11257231 11606597 11927604 12121969 12181739 12660240 12865429 15078891 15300255 15749826 17686459 23180781 ubiquitination reaction,physical association affinity chromatography technology,anti tag coimmunoprecipitation,far western blotting,gst pull down,surface plasmon resonance,ubiquitination reaction InnateDB
DIABLO BIRC2 11606597 16282325 23180781 ubiquitination reaction,physical association affinity chromatography technology,ubiquitination reaction InnateDB
DIABLO BIRC3 11606597 23180781 physical association affinity chromatography technology InnateDB
DIABLO BIRC5 16540654 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3 DIABLO 17277885 23180781 physical association anti tag coimmunoprecipitation,two hybrid,gst pull down InnateDB
MAPK10 DIABLO 17686459 23180781 phosphorylation reaction in-gel kinase assay InnateDB
TNFSF14 DIABLO 12571250 23180781 physical association anti tag coimmunoprecipitation InnateDB
LTBR DIABLO 12571250 23180781 physical association anti tag coimmunoprecipitation InnateDB
UBE2D3 DIABLO 12525502 23180781 ubiquitination reaction enzymatic study InnateDB
TOLLIP DIABLO 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF2 DIABLO 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF1 DIABLO 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
DIABLO DIABLO 10929711 11583623 14523016 21295084 26467481 interaction type,bind,up-regulates,down-regulates,down-regulates activity,down-regulates quantity N/A Signor

Source Target Pmid Interactiontype Methods Database
ETS1 DIABLO 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DIABLO 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF DIABLO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DIABLO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DIABLO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DIABLO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DIABLO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DIABLO 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DIABLO 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000076995 DIABLO 21169019 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000003ABC4 DIABLO 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 DIABLO 23622248 25416803 28097098 mrna cleavage,inhibition array technology,clash TarBase
URS0000568FF8 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C85C7 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000059EB31 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075A611 DIABLO 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK8 DIABLO 22135298 phosphorylation N/A PhosphoSite
AKT1 DIABLO 22135298 phosphorylation N/A PhosphoSite
BIRC7 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO BIRC7 25361965 interaction type N/A PTMCode2
LTBR DIABLO 25361965 interaction type N/A PTMCode2
DIABLO LTBR 25361965 interaction type N/A PTMCode2
HTRA2 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO HTRA2 25361965 interaction type N/A PTMCode2
DIABLO BIRC5 25361965 interaction type N/A PTMCode2
BIRC5 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO CASP9 25361965 interaction type N/A PTMCode2
CASP9 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO XIAP 25361965 interaction type N/A PTMCode2
XIAP DIABLO 25361965 interaction type N/A PTMCode2
DIABLO BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO BIRC8 25361965 interaction type N/A PTMCode2
BIRC8 DIABLO 25361965 interaction type N/A PTMCode2
BIRC2 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO BIRC2 25361965 interaction type N/A PTMCode2
BIRC3 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO BIRC3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DYNLL1 DIABLO 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
DYNLL2 DIABLO 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
SEC22A DIABLO 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DHRS1 DIABLO 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBL4A DIABLO 25348397 N/A physical interaction ComPPI
TRAF6 DIABLO 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DERL2 DIABLO 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XIAP DIABLO 10929712 11242052 11257231 11604410 11801603 14525934 16282325 21185211 22465666 23251006 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,pull down,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP9 DIABLO 11242052 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BIRC8 DIABLO 15485395 25348397 26186194 27898060 N/A physical interaction ComPPI,OmniPath
PRKCD DIABLO 22465666 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DLD DIABLO 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EEF1A1 DIABLO 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EEA1 DIABLO 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRAF1 DIABLO 25348397 N/A physical interaction ComPPI
TRAF2 DIABLO 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCE1 DIABLO 25348397 N/A physical interaction ComPPI
USP13 DIABLO 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP1B1 DIABLO 25348397 N/A physical interaction ComPPI
NR4A1 DIABLO 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GABPA DIABLO 25348397 N/A physical interaction ComPPI
MAML2 DIABLO 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2K DIABLO 20537984 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BEX3 DIABLO 14525934 15178455 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DIABLO LTBR 12571250 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DIABLO BIRC2 10929712 12525502 14525934 16282325 19153467 24234451 25348397 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DIABLO BIRC3 10929712 12525502 14525934 16282325 24234451 25348397 association,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
DIABLO BIRC5 12660240 14525934 23251006 24234451 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DIABLO BIRC7 11801603 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DIABLO HTRA2 11604410 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DIABLO BIRC6 14525934 15200957 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DIABLO NAIP 25348397 N/A physical interaction ComPPI
DIABLO TNFSF14 25348397 N/A physical interaction ComPPI
DIABLO TOLLIP 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DIABLO UFM1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DIABLO EEF1A1P5 25348397 N/A physical interaction ComPPI
DIABLO ZNF746 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DIABLO ELAVL1 25348397 N/A physical interaction ComPPI
DIABLO MALT1 25348397 N/A physical interaction ComPPI
DIABLO AREL1 25348397 N/A physical interaction ComPPI
DIABLO SLC25A47 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DIABLO ARNT 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DIABLO GMPPB 25348397 N/A physical interaction ComPPI
DIABLO LIMCH1 25348397 N/A physical interaction ComPPI
DIABLO SSRP1 25348397 N/A physical interaction ComPPI
DIABLO ARL6IP1 24234451 25348397 25416956 26871637 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DIABLO CD40 25348397 N/A physical interaction ComPPI
DIABLO SURF2 25348397 N/A physical interaction ComPPI
DIABLO LIMA1 25348397 N/A physical interaction ComPPI
DIABLO MTMR14 25348397 N/A physical interaction ComPPI
DIABLO DUSP22 25348397 N/A physical interaction ComPPI
DIABLO MTFR1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO KLHL2 25348397 N/A physical interaction ComPPI
DIABLO GFER 25348397 N/A physical interaction ComPPI
DIABLO HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DIABLO HSPD1 20627101 21274005 24234451 25348397 colocalization cosedimentation in solution,cosedimentation through density gradient ComPPI,IntAct
DIABLO SLC66A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO RMDN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO MPC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO HSD17B13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO FADS6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO SFT2D1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO APOC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO MICOS13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO DGAT2L6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO SLC17A9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO FKBP7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DIABLO DIABLO 10972280 14525934 N/A experimental interaction detection HPRD
MKI67 DIABLO 24234451 26949251 association anti tag coimmunoprecipitation IntAct
E2F1 DIABLO 18660514 24234451 physical association chromatin immunoprecipitation assay IntAct
PAWR DIABLO 18660514 24234451 physical association chromatin immunoprecipitation assay IntAct
MAPK10 DIABLO 17686459 27898060 inhibition N/A OmniPath
TRAF2 DIABLO 20562859 21903422 27898060 N/A N/A OmniPath
BIRC6 DIABLO 15200957 15300255 15507451 15781261 20957035 22788920 24302728 27898060 inhibition N/A OmniPath
DIABLO BIRC6 15200957 15300255 15507451 15781261 20957035 22788920 24302728 27898060 inhibition N/A OmniPath
BID DIABLO 11741882 11859412 27898060 N/A N/A OmniPath
DIABLO CASP9 10929711 11242052 27898060 stimulant N/A OmniPath
AKT1 DIABLO 24038446 27898060 N/A N/A OmniPath
BAK1 DIABLO 12232790 12670926 12941691 14585074 27898060 stimulant N/A OmniPath
XIAP DIABLO 10929712 10972280 11140637 11140638 11157976 11242052 11257230 11257231 11602612 11604410 11606597 11801595 11801603 11927604 12121969 12181739 12218061 12511567 12525502 12660240 12865429 14512414 14523016 15078891 15178455 15200957 15280366 15300255 15507451 15541727 15650747 15749826 15781261 16282325 17179183 17686459 17724022 19153467 19506082 19667203 20957035 21185211 22465666 23251006 23818254 25246529 25801170 27898060 inhibition N/A OmniPath
DIABLO XIAP 10929711 10929712 10972280 11140637 11140638 11157976 11242052 11257230 11257231 11583623 11602612 11604410 11606597 11801595 11801603 11927604 12121969 12181739 12218061 12511567 12525502 12660240 12865429 14512414 14523016 15078891 15178455 15200957 15280366 15300255 15507451 15541727 15650747 15749826 15781261 16282325 17179183 17686459 17724022 19153467 19506082 19667203 20957035 21185211 22465666 23251006 23818254 25246529 25801170 27898060 inhibition,stimulant N/A OmniPath
CASP2 DIABLO 11832478 27898060 stimulant N/A OmniPath
BIRC7 DIABLO 11801603 12620238 15485396 16729033 19284370 22902369 26186194 27898060 inhibition N/A OmniPath
BIRC2 DIABLO 10929712 11606597 12218061 12525502 12865429 14960576 16282325 18022362 18022363 19153467 19506082 20957035 25065467 25246529 27898060 N/A N/A OmniPath
DIABLO BIRC2 10929712 11606597 12218061 12525502 12865429 14960576 16282325 18022362 18022363 19153467 19506082 20957035 25065467 25246529 27898060 inhibition,stimulant N/A OmniPath
BIRC3 DIABLO 10929712 11606597 12525502 14960576 18022362 18022363 20957035 25065467 27898060 inhibition N/A OmniPath
DIABLO BIRC3 10929711 10929712 11606597 12525502 14960576 18022362 18022363 20957035 25065467 27898060 inhibition,stimulant N/A OmniPath
BAX DIABLO 11782443 12232790 12670894 14585074 27898060 stimulant N/A OmniPath
BIRC5 DIABLO 10929711 12660240 15541727 16540654 17546047 21536684 23251006 27898060 inhibition N/A OmniPath
DIABLO BIRC5 10929711 12660240 15541727 16540654 17546047 21536684 23251006 27898060 inhibition N/A OmniPath
MAPK8 DIABLO 25310587 27898060 N/A N/A OmniPath
DIABLO TRAF3 17277885 27898060 N/A N/A OmniPath
TOLLIP DIABLO 21903422 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008C14A5 DIABLO 27087310 direct interaction,inhibition N/A NPInter

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