Gene Information gene info

  1. Home

GENE：AKT2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AKT2
FullNmae AKT serine/threonine kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:392
EnsembleID ENSG00000105221
Uniprot P31751

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AKT2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AKT2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
AKT2 GO:0001934,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005769,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005938,GO:0005978,GO:0006006,GO:0006417,GO:0007165,GO:0008284,GO:0008286,GO:0008286,GO:0008643,GO:0010748,GO:0010907,GO:0010918,GO:0016310,GO:0018105,GO:0030334,GO:0030335,GO:0031340,GO:0032000,GO:0032287,GO:0032587,GO:0032869,GO:0032991,GO:0035556,GO:0036211,GO:0043066,GO:0043231,GO:0045444,GO:0045725,GO:0046326,GO:0046872,GO:0051726,GO:0060644,GO:0065002,GO:0071486,GO:0072659,GO:0090314,GO:0097473,GO:0106310,GO:0140677,GO:2000147

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AKT2 hsa:208 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
AKT2 hsa:208 path:hsa01522 Endocrine resistance - Homo sapiens (human)
AKT2 hsa:208 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
AKT2 hsa:208 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04140 Autophagy - animal - Homo sapiens (human)
AKT2 hsa:208 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04210 Apoptosis - Homo sapiens (human)
AKT2 hsa:208 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
AKT2 hsa:208 path:hsa04218 Cellular senescence - Homo sapiens (human)
AKT2 hsa:208 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
AKT2 hsa:208 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
AKT2 hsa:208 path:hsa04510 Focal adhesion - Homo sapiens (human)
AKT2 hsa:208 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
AKT2 hsa:208 path:hsa04611 Platelet activation - Homo sapiens (human)
AKT2 hsa:208 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
AKT2 hsa:208 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
AKT2 hsa:208 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
AKT2 hsa:208 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
AKT2 hsa:208 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
AKT2 hsa:208 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
AKT2 hsa:208 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
AKT2 hsa:208 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
AKT2 hsa:208 path:hsa04929 GnRH secretion - Homo sapiens (human)
AKT2 hsa:208 path:hsa04931 Insulin resistance - Homo sapiens (human)
AKT2 hsa:208 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
AKT2 hsa:208 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
AKT2 hsa:208 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
AKT2 hsa:208 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
AKT2 hsa:208 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
AKT2 hsa:208 path:hsa05010 Alzheimer disease - Homo sapiens (human)
AKT2 hsa:208 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
AKT2 hsa:208 path:hsa05131 Shigellosis - Homo sapiens (human)
AKT2 hsa:208 path:hsa05132 Salmonella infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05135 Yersinia infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05142 Chagas disease - Homo sapiens (human)
AKT2 hsa:208 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
AKT2 hsa:208 path:hsa05152 Tuberculosis - Homo sapiens (human)
AKT2 hsa:208 path:hsa05160 Hepatitis C - Homo sapiens (human)
AKT2 hsa:208 path:hsa05161 Hepatitis B - Homo sapiens (human)
AKT2 hsa:208 path:hsa05162 Measles - Homo sapiens (human)
AKT2 hsa:208 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05164 Influenza A - Homo sapiens (human)
AKT2 hsa:208 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
AKT2 hsa:208 path:hsa05200 Pathways in cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
AKT2 hsa:208 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
AKT2 hsa:208 path:hsa05210 Colorectal cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)
AKT2 hsa:208 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05213 Endometrial cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05214 Glioma - Homo sapiens (human)
AKT2 hsa:208 path:hsa05215 Prostate cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05218 Melanoma - Homo sapiens (human)
AKT2 hsa:208 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
AKT2 hsa:208 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
AKT2 hsa:208 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05224 Breast cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
AKT2 hsa:208 path:hsa05226 Gastric cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
AKT2 hsa:208 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
AKT2 hsa:208 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
AKT2 hsa:208 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TWIST1 AKT2 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21502402 21733352 2191300 21919891 22406545 22945800 26192618 7768934 9278421 interaction type N/A ACSN
AKT2 XIAP 14645242 23180781 phosphorylation reaction protein kinase assay InnateDB
AKT2 GSK3B 12434148 23180781 physical association x-ray crystallography InnateDB
AKT2 SIK2 17805301 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MYO5A AKT2 17515613 23180781 phosphorylation reaction in-gel kinase assay InnateDB
AKT2 CHUK 12048203 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
AKT2 PDK1 23180781 9512493 phosphorylation reaction protein kinase assay InnateDB
AKT2 ESR1 11507039 23180781 phosphorylation reaction protein kinase assay InnateDB
AKT2 MAPK8 12697749 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT2 MAP3K5 12697749 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
AKT2 FSHR 15070827 23180781 physical association anti tag coimmunoprecipitation InnateDB
APPL1 AKT2 10490823 15070827 17030088 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TCL1A AKT2 11707444 15169787 23180781 physical association anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,nuclear magnetic resonance,x ray scattering InnateDB
AKT2 CMC4 15169787 23180781 physical association nuclear magnetic resonance InnateDB
PHLPP1 AKT2 17386267 23180781 physical association anti tag coimmunoprecipitation InnateDB
PHLPP2 AKT2 17386267 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT2 PLEKHO1 17942896 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SH3RF1 AKT2 17535800 23180781 phosphorylation reaction in-gel kinase assay InnateDB
AKT2 MTCP1 15169787 23180781 physical association fluorescence polarization spectroscopy InnateDB
AKT2 CDKN1A 16982699 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT2 MAPKAPK2 16793766 23180781 phosphorylation reaction in-gel kinase assay InnateDB
AKT2 PRKCZ 18353613 23180781 physical association anti tag coimmunoprecipitation InnateDB
CTNNB1 AKT2 17287208 23180781 phosphorylation reaction in-gel kinase assay InnateDB
CLIP3 AKT2 19139280 23180781 physical association anti tag coimmunoprecipitation InnateDB
KHSRP AKT2 17177604 23180781 phosphorylation reaction in-gel kinase assay InnateDB
ZFP36L1 AKT2 15538381 17030608 23180781 phosphorylation reaction in-gel kinase assay,protein kinase assay InnateDB
CASP3 AKT2 17544405 23180781 cleavage reaction enzymatic study,protease assay InnateDB
PTEN AKT2 10970827 23331499 inhibition N/A SignaLink,SignaLink
PDPK1 AKT2 15191648 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AKT1S1 AKT2 20005715 interaction type N/A PSP,SignaLink
APPL1 AKT2 10490823 20005715 21071413 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
AR AKT2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 AKT2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 AKT2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 AKT2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 AKT2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C AKT2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF AKT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AKT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AKT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AKT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AKT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 AKT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 AKT2 20514445 trascriptional regulation,stimulation inferred by curator TFlink
PROX1 AKT2 22982861 trascriptional regulation,stimulation inferred by curator TFlink
RELA AKT2 20514445 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 AKT2 21876555 22982861 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 AKT2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000032015F AKT2 20409325 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D AKT2 20048743 rna interference,inhibition experimental interaction detection,western blot miRSponge
URS000019D79B AKT2 22552290 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000032015F AKT2 20371350 20409325 25416803 27418134 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00004DA9DB AKT2 21354697 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr TarBase
URS000019D79B AKT2 22552290 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D AKT2 20048743 25416803 mrna cleavage,inhibition experimental interaction detection,western blot TarBase
URS000002103A AKT2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D AKT2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE AKT2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 AKT2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D AKT2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000076995 AKT2 24076586 25416803 25428377 26512921 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000272A3D AKT2 25416803 25428377 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001E3523 AKT2 20371350 24465609 25416803 26102366 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS000029979D AKT2 25288334 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000324096 AKT2 25288334 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000346991 AKT2 24337067 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00001A7F58 AKT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003E6479 AKT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000016C318 AKT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075A9CF AKT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003FA24D AKT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 AKT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001D69F6 AKT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 AKT2 25416803 27878305 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000008A99 AKT2 25416803 28404925 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PDPK1 AKT2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
AKT2 MAP3K5 22135298 phosphorylation N/A PhosphoSite
AKT2 HTRA2 22135298 phosphorylation N/A PhosphoSite
AKT2 EZR 22135298 phosphorylation N/A PhosphoSite
AKT2 CBY1 22135298 phosphorylation N/A PhosphoSite
AKT2 XIAP 22135298 phosphorylation N/A PhosphoSite
AKT2 FLNC 22135298 phosphorylation N/A PhosphoSite
AKT2 ESR1 22135298 phosphorylation N/A PhosphoSite
AKT2 RACGAP1 22135298 phosphorylation N/A PhosphoSite
AKT2 H3C1 22135298 phosphorylation N/A PhosphoSite
AKT2 WIPF1 22135298 phosphorylation N/A PhosphoSite
AKT2 EDC3 22135298 phosphorylation N/A PhosphoSite
AKT2 KHSRP 22135298 phosphorylation N/A PhosphoSite
AKT2 PIP5K1C 22135298 phosphorylation N/A PhosphoSite
AKT2 CHUK 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
AKT2 CTNNB1 22135298 phosphorylation N/A PhosphoSite
AKT2 ANKRD2 22135298 phosphorylation N/A PhosphoSite
AKT2 C2CD5 22135298 phosphorylation N/A PhosphoSite
AKT2 SH3RF1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
AKT2 PDK1 22135298 phosphorylation N/A PhosphoSite
AKT2 PPIF 22135298 phosphorylation N/A PhosphoSite
AKT2 GAPDH 22135298 phosphorylation N/A PhosphoSite
APPL1 AKT2 25361965 interaction type N/A PTMCode2
AKT2 APPL1 25361965 interaction type N/A PTMCode2
GSK3B AKT2 25361965 interaction type N/A PTMCode2
AKT2 GSK3B 25361965 interaction type N/A PTMCode2
AKT1S1 AKT2 25361965 interaction type N/A PTMCode2
AKT2 AKT1S1 25361965 interaction type N/A PTMCode2
TCL1B AKT2 25361965 interaction type N/A PTMCode2
AKT2 TCL1B 25361965 interaction type N/A PTMCode2
CASP3 AKT2 25361965 interaction type N/A PTMCode2
AKT2 CASP3 25361965 interaction type N/A PTMCode2
CHUK AKT2 25361965 interaction type N/A PTMCode2
TCL1A AKT2 25361965 interaction type N/A PTMCode2
AKT2 TCL1A 25361965 interaction type N/A PTMCode2
AKT1 AKT2 25361965 interaction type N/A PTMCode2
AKT2 AKT1 25361965 interaction type N/A PTMCode2
SLC2A4 AKT2 25361965 interaction type N/A PTMCode2
AKT2 SLC2A4 25361965 interaction type N/A PTMCode2
SH3RF1 AKT2 25361965 interaction type N/A PTMCode2
AKT2 PDPK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TCL1A AKT2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SORBS3 AKT2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VIM AKT2 20856200 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDKN1A AKT2 25348397 N/A physical interaction ComPPI
TRIB3 AKT2 25348397 N/A in vitro,in vivo ComPPI
XIAP AKT2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SNAI1 AKT2 25348397 N/A physical interaction ComPPI
HSP90AB1 AKT2 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
APPL1 AKT2 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
PICK1 AKT2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RACGAP1 AKT2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SETDB1 AKT2 17577629 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP3 AKT2 17544405 24234451 25348397 cleavage reaction enzymatic study ComPPI,IntAct
PRKDC AKT2 25348397 N/A physical interaction ComPPI
TPM2 AKT2 25348397 N/A physical interaction ComPPI
GSK3B AKT2 12434148 24234451 25348397 N/A x-ray crystallography,physical interaction,in vitro ComPPI,IntAct
SLC2A4 AKT2 25348397 N/A in vitro ComPPI
PIK3CB AKT2 25348397 N/A physical interaction ComPPI
UBB AKT2 25348397 N/A physical interaction ComPPI
APOA1 AKT2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AA1 AKT2 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
PDPK1 AKT2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAP3K5 AKT2 25348397 N/A physical interaction ComPPI
EIF4EBP1 AKT2 25348397 N/A physical interaction ComPPI
PRKCZ AKT2 25348397 N/A physical interaction ComPPI
PPP2CA AKT2 25348397 N/A physical interaction ComPPI
SORBS2 AKT2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR2F2 AKT2 25348397 N/A physical interaction ComPPI
TSC2 AKT2 25348397 N/A in vivo ComPPI
GRK5 AKT2 25348397 N/A physical interaction ComPPI
CSK AKT2 25348397 N/A physical interaction ComPPI
RPE AKT2 25348397 N/A physical interaction ComPPI
ARRB2 AKT2 19122674 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SPRR2A AKT2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EGFR AKT2 25348397 N/A physical interaction ComPPI
VHL AKT2 25348397 N/A physical interaction ComPPI
FOXO4 AKT2 25348397 N/A in vivo ComPPI
CHUK AKT2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
UCHL1 AKT2 25348397 N/A physical interaction ComPPI
GGA1 AKT2 25348397 N/A physical interaction ComPPI
TFAP2C AKT2 24234451 24835590 25348397 physical association two hybrid ComPPI,IntAct
H3C1 AKT2 25348397 N/A physical interaction ComPPI
RAB3D AKT2 25348397 N/A in vitro ComPPI
CDC37 AKT2 12176997 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
SH3RF1 AKT2 17535800 24234451 25348397 phosphorylation reaction two hybrid,physical interaction,protein kinase assay,in vitro ComPPI,IntAct
FSHR AKT2 25348397 N/A physical interaction,in vivo ComPPI
ESR1 AKT2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
CCL14 AKT2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCNA2 AKT2 24234451 24670654 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AKT1 AKT2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SKI AKT2 25348397 N/A physical interaction ComPPI
AP4M1 AKT2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2O AKT2 25348397 N/A physical interaction ComPPI
ABCG8 AKT2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PLEKHO1 AKT2 25348397 N/A physical interaction ComPPI
POLR1B AKT2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDK3 AKT2 25348397 N/A physical interaction ComPPI
GNB1 AKT2 25348397 N/A physical interaction ComPPI
AKT2 MTCP1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
AKT2 TCL1B 25348397 N/A physical interaction,in vitro,in vivo ComPPI
AKT2 AKT1S1 25348397 N/A in vitro,in vivo ComPPI
AKT2 TTC3 25348397 N/A physical interaction ComPPI
AKT2 APP 25348397 N/A physical interaction ComPPI
AKT2 HSP90AA2P 25348397 N/A physical interaction ComPPI
AKT2 PNPLA3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
AKT2 SNX27 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
AKT2 APOB 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKT2 NAMPT 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKT2 TMED2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKT2 POFUT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKT2 STEAP4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKT2 CLIP3 25348397 N/A physical interaction ComPPI
AKT2 PSMD9 25348397 N/A physical interaction ComPPI
AKT2 PIK3CD 25348397 N/A physical interaction ComPPI
AKT2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
AKT2 USP9Y 25348397 N/A physical interaction ComPPI
AKT2 FAT3 25348397 N/A physical interaction ComPPI
AKT2 NSMCE4A 25348397 N/A physical interaction ComPPI
AKT2 EGLN1 25348397 N/A physical interaction ComPPI
AKT2 WDR26 25348397 N/A physical interaction ComPPI
AKT2 FKBP5 25348397 N/A physical interaction ComPPI
AKT2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
AKT2 CTNNB1 17287208 27898060 stimulant N/A OmniPath
AKT2 PTPN1 11579209 27898060 inhibition N/A OmniPath
AKT2 CBY1 25909186 27898060 N/A N/A OmniPath
AKT2 NOS3 24379783 27898060 stimulant N/A OmniPath
PTEN AKT2 10970827 27898060 inhibition N/A OmniPath
AKT2 CDKN1A 16982699 21933447 27898060 inhibition,stimulant N/A OmniPath
CDKN1A AKT2 16982699 27898060 N/A N/A OmniPath
MAPKAPK2 AKT2 16793766 27898060 N/A N/A OmniPath
CHUK AKT2 12048203 19609947 27898060 N/A N/A OmniPath
AKT2 CHUK 12048203 19609947 27898060 stimulant N/A OmniPath
AKT2 CREB1 27898060 9829964 stimulant N/A OmniPath
AKT2 AKT1S1 12524439 14973226 17277771 17386266 18669648 19413330 19651622 20068231 27898060 inhibition N/A OmniPath
AKT2 GAPDH 18183946 21979951 27898060 N/A N/A OmniPath
AKT2 FOXO4 11313479 16272144 19664994 21620960 27898060 inhibition N/A OmniPath
AKT2 TCL1A 10983986 11707444 15169787 27898060 N/A N/A OmniPath
TCL1A AKT2 10983986 11707444 15169787 27898060 stimulant N/A OmniPath
AKT2 FOXO3 19188143 27898060 inhibition N/A OmniPath
AKT2 CDKN1B 12244303 27898060 inhibition N/A OmniPath
CASP3 AKT2 17544405 27898060 N/A N/A OmniPath
AKT2 CASP9 15004527 27898060 9812896 inhibition,stimulant N/A OmniPath
AKT2 MDM2 11504915 27898060 stimulant N/A OmniPath
AKT2 PPARGC1A 17554339 27898060 inhibition N/A OmniPath
AKT2 BRAF 10869359 27898060 inhibition N/A OmniPath
AKT2 FOXO1 10377430 27898060 inhibition N/A OmniPath
AKT2 NFKB1 17604717 27898060 stimulant N/A OmniPath
ESR1 AKT2 11139588 11432835 11507039 27898060 9528769 N/A N/A OmniPath
AKT2 ESR1 10428798 10949034 11108261 11139588 11432835 11507039 15528270 15778291 16113102 16168121 16741565 17158758 18367407 18984578 19104930 19887647 19940156 20043841 20418363 21602804 22826433 23390529 23861392 27898060 7838153 8308015 9337862 9528769 stimulant N/A OmniPath
AKT2 BAD 10949026 27898060 inhibition,stimulant N/A OmniPath
PDPK1 AKT2 10822383 11359783 12048203 12434148 15456405 15743829 15890450 20059950 27898060 9374542 9512493 stimulant N/A OmniPath
AKT2 SH3RF1 14504284 17535800 27898060 inhibition N/A OmniPath
SH3RF1 AKT2 14504284 17535800 27898060 N/A N/A OmniPath
AKT2 XIAP 14645242 17537996 23749209 26314849 27898060 stimulant N/A OmniPath
XIAP AKT2 14645242 27898060 N/A N/A OmniPath
AKT2 H3C1 19363025 25813038 27898060 N/A N/A OmniPath
AKT2 GSK3A 16023596 27898060 inhibition N/A OmniPath
AKT2 MAP3K5 11154276 12697749 27898060 inhibition N/A OmniPath
AKT2 STK4 23431053 27898060 inhibition N/A OmniPath
PDK1 AKT2 27898060 9512493 stimulant N/A OmniPath
AKT2 RACGAP1 24019536 27898060 N/A N/A OmniPath
PRKCZ AKT2 18353613 27898060 N/A N/A OmniPath
AKT2 EZR 15531580 27898060 stimulant N/A OmniPath
AKT2 STK3 20231902 27898060 inhibition N/A OmniPath
TWIST1 AKT2 17332325 27898060 stimulant N/A OmniPath
AKT2 RAF1 10576742 27898060 inhibition N/A OmniPath
PHLPP1 AKT2 15808505 17386267 19261608 27898060 inhibition N/A OmniPath
AKT2 PHLPP1 15808505 17386267 19261608 27898060 N/A N/A OmniPath
TNF AKT2 11287630 27898060 stimulant N/A OmniPath
AKT2 ZFP36L1 15538381 17030608 27898060 N/A N/A OmniPath
AKT2 TSC2 12150915 12167664 12172553 19188143 27898060 inhibition N/A OmniPath
AKT2 EP300 16926151 17964260 27898060 stimulant N/A OmniPath
PPP2CA AKT2 18160256 27898060 inhibition N/A OmniPath
AKT2 MTOR 12782654 27898060 stimulant N/A OmniPath
AKT2 GSK3B 12434148 16293724 23552696 27898060 inhibition N/A OmniPath
GSK3B AKT2 12434148 16293724 27898060 N/A N/A OmniPath
AKT2 HSPB1 19593530 27898060 inhibition N/A OmniPath
MAPK8 AKT2 12697749 27898060 N/A N/A OmniPath
AKT2 HTRA2 17311912 27898060 inhibition N/A OmniPath
AKT2 CLIP3 19139280 27898060 N/A N/A OmniPath
CLIP3 AKT2 19139280 27898060 N/A N/A OmniPath
FSHR AKT2 15070827 27898060 N/A N/A OmniPath
AKT2 KHSRP 17177604 27898060 N/A N/A OmniPath
AKT2 APPL1 10490823 15070827 17030088 27898060 N/A N/A OmniPath
APPL1 AKT2 10490823 15070827 17030088 27898060 N/A N/A OmniPath
PLEKHO1 AKT2 17942896 27898060 N/A N/A OmniPath
AKT2 FLNC 15461588 27898060 N/A N/A OmniPath
AKT2 MYO5A 17515613 27898060 N/A N/A OmniPath
AKT2 MTCP1 11707444 15169787 27898060 N/A N/A OmniPath
MTCP1 AKT2 10983986 11707444 15169787 27898060 stimulant N/A OmniPath
AKT2 SIK2 17805301 27898060 N/A N/A OmniPath
AKT2 CMC4 15169787 27898060 N/A N/A OmniPath
AKT2 PHLPP2 17386267 27898060 N/A N/A OmniPath
PHLPP2 AKT2 17386267 19261608 27898060 inhibition N/A OmniPath
GNG12 AKT2 16293724 27898060 stimulant N/A OmniPath
NUDT3 AKT2 10983986 27898060 stimulant N/A OmniPath
AKT2 GATA6 25969542 27898060 N/A N/A OmniPath
AKT2 POU5F1 23041284 27898060 stimulant N/A OmniPath
PPP2CB AKT2 27898060 8650155 inhibition N/A OmniPath
TCL1B AKT2 10983986 11707444 27898060 stimulant N/A OmniPath
AKT2 PIP5K1C 26149501 27898060 N/A N/A OmniPath
AKT2 ANKRD2 21737686 27898060 N/A N/A OmniPath
AKT2 EDC3 20051463 27898060 N/A N/A OmniPath
AKT2 C2CD5 21907143 27898060 N/A N/A OmniPath

Visualization










  Return