Gene Information gene info

GENE:CAPN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CAPN1
FullNmae calpain 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1476
EnsembleID ENSG00000014216
Uniprot P07384

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CAPN1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CAPN1 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CAPN1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CAPN1 autophagy 35941978 Seven autophagy-related genes (CAPN1, CDKN1B, DNAJB1, GNAI3, MTMR14, RHEB, and SIRT2) were identified as independent predictors of prognosis retulator signature
CAPN1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CAPN1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CAPN1 GO:0001533,GO:0004198,GO:0004198,GO:0004198,GO:0004198,GO:0005509,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005764,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005925,GO:0006508,GO:0006508,GO:0006508,GO:0006508,GO:0008233,GO:0008284,GO:0016020,GO:0016241,GO:0032801,GO:0050790,GO:0060056,GO:0070062,GO:0097264,GO:0110158,GO:1904813,GO:2000310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CAPN1 hsa:823 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
CAPN1 hsa:823 path:hsa04210 Apoptosis - Homo sapiens (human)
CAPN1 hsa:823 path:hsa04217 Necroptosis - Homo sapiens (human)
CAPN1 hsa:823 path:hsa04218 Cellular senescence - Homo sapiens (human)
CAPN1 hsa:823 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CAPN1 hsa:823 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CAPN1 hsa:823 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CAPN1 BID 11404357 11940658 17264306 18469004 19931333 26192618 interaction type N/A ACSN
CAPN1 XIAP 19931333 26192618 28747251 interaction type N/A ACSN
CAPN1 AIFM1 11404357 11940658 17264306 18469004 19931333 26192618 interaction type N/A ACSN
CAPN1 BAX 19931333 21887410 23242420 26192618 interaction type N/A ACSN
CAPN1 PTPN1 12857726 23180781 cleavage reaction protease assay InnateDB
CAPN1 ATG5 16998475 23180781 cleavage reaction protease assay InnateDB
CAPN1 STAT3 21988832 23180781 physical association pull down InnateDB
CAPN1 CAPN1 25969760 26467481 cleavage reaction,up-regulates activity,down-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
ETS1 CAPN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CAPN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CAPN1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CAPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CAPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CAPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CAPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CAPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CAPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CAPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CAPN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 CAPN1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000821E0 CAPN1 22012620 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000016FD1B CAPN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000015B295 CAPN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000122F23 CAPN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA CAPN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA CAPN1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000016C318 CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E6479 CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000017CCCB CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003677B2 CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000049704B CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F1B8C CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002578DA CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000047A8F CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000214763 CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004526F6 CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003AD2AA CAPN1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CAPN1 CDK5R1 25361965 interaction type N/A PTMCode2
CDK5R1 CAPN1 25361965 interaction type N/A PTMCode2
CAPN1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CAPN1 25361965 interaction type N/A PTMCode2
CAPN1 CAST 25361965 interaction type N/A PTMCode2
CAST CAPN1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TBC1D22B CAPN1 25348397 N/A physical interaction ComPPI
LGALS3 CAPN1 25348397 N/A physical interaction ComPPI
DES CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BAG3 CAPN1 25348397 N/A physical interaction ComPPI
VIM CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CASP14 CAPN1 12200134 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TINAGL1 CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PTGDS CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RAD21 CAPN1 21876002 22145905 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MCM2 CAPN1 25348397 N/A physical interaction ComPPI
CDK5R1 CAPN1 10830966 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BCL2L1 CAPN1 12000759 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CBL CAPN1 14525934 25348397 8695851 N/A experimental interaction detection,in vitro ComPPI,HPRD
HIF1A CAPN1 25348397 N/A physical interaction ComPPI
FHL2 CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SLC9A3R1 CAPN1 25348397 N/A physical interaction ComPPI
ZIC1 CAPN1 25348397 N/A physical interaction ComPPI
KTN1 CAPN1 25348397 N/A physical interaction ComPPI
RAP1GDS1 CAPN1 25348397 N/A physical interaction ComPPI
INPP4A CAPN1 14525934 25348397 27898060 9110986 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
NTRK1 CAPN1 25348397 N/A physical interaction ComPPI
NIT1 CAPN1 25348397 N/A physical interaction ComPPI
KNG1 CAPN1 14525934 25348397 27898060 3038169 8253784 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
F2RL1 CAPN1 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB3 CAPN1 14525934 25348397 7592818 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN1 CAPN1 19712109 24234451 25348397 9407132 cleavage reaction,enzymatic reaction,physical association enzyme linked immunosorbent assay,protease assay ComPPI,IntAct
CASP7 CAPN1 25348397 N/A physical interaction ComPPI
TIRAP CAPN1 23023391 24234451 25348397 27898060 cleavage reaction protease assay ComPPI,IntAct,OmniPath
NEFM CAPN1 25348397 N/A physical interaction ComPPI
NFKBIA CAPN1 10521480 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
F2R CAPN1 10978167 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
PRMT5 CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
HNRNPL CAPN1 25348397 N/A physical interaction ComPPI
RPS6KA1 CAPN1 25348397 N/A physical interaction ComPPI
SPTAN1 CAPN1 14525934 25348397 8993318 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EIF6 CAPN1 25348397 N/A physical interaction ComPPI
ACTN2 CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ECT2 CAPN1 25348397 N/A physical interaction ComPPI
BCCIP CAPN1 25348397 N/A physical interaction ComPPI
YWHAQ CAPN1 25348397 N/A physical interaction ComPPI
GRIN2B CAPN1 10846184 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CREG1 CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ARF6 CAPN1 14525934 16737952 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ARRB2 CAPN1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSEN2 CAPN1 10677567 14525934 25348397 27898060 9852298 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
SPTBN1 CAPN1 14525934 25348397 27898060 9989581 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
FANCC CAPN1 25348397 N/A physical interaction ComPPI
SYNCRIP CAPN1 25348397 N/A physical interaction ComPPI
MYBPC3 CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MTREX CAPN1 25348397 N/A physical interaction ComPPI
TLE5 CAPN1 25348397 N/A physical interaction ComPPI
HSPA9 CAPN1 25348397 N/A physical interaction ComPPI
RP9 CAPN1 25348397 N/A physical interaction ComPPI
VCAM1 CAPN1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 CAPN1 25348397 N/A physical interaction ComPPI
SYNE1 CAPN1 25348397 N/A two hybrid ComPPI
ASS1 CAPN1 25348397 N/A physical interaction ComPPI
CAPN2 CAPN1 25348397 N/A physical interaction ComPPI
COL3A1 CAPN1 12358155 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
HNRNPR CAPN1 25348397 N/A physical interaction ComPPI
MVD CAPN1 25348397 N/A physical interaction ComPPI
CAST CAPN1 12684003 14525934 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
FNTA CAPN1 25348397 N/A physical interaction ComPPI
COL1A1 CAPN1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
HNRNPD CAPN1 25348397 N/A physical interaction ComPPI
STAT3 CAPN1 21988832 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
INA CAPN1 25348397 N/A physical interaction ComPPI
EIF4E CAPN1 25348397 N/A physical interaction ComPPI
RCAN1 CAPN1 25348397 N/A enzymatic study ComPPI
CAPNS1 CAPN1 12591934 14525934 19712109 24234451 25348397 26496610 cleavage reaction,association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,protease assay,in vivo ComPPI,HPRD,IntAct
CAPN1 IL1A 14525934 25348397 7499244 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAPN1 SH3BGR 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CAPN1 UFSP2 12358155 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
CAPN1 NFE2L1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CAPN1 GPT 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CAPN1 LAMTOR1 12358155 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
CAPN1 SLIT3 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CAPN1 CTSC 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CAPN1 ECHS1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CAPN1 FANCA 25348397 N/A physical interaction ComPPI
CAPN1 PALB2 25348397 N/A physical interaction ComPPI
CAPN1 FANCG 25348397 N/A physical interaction ComPPI
CAPN1 GAS2 25348397 N/A physical interaction ComPPI
CAPN1 CLEC4G 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CAPN1 SIRT7 25348397 N/A physical interaction ComPPI
CAPN1 FN1 25348397 N/A physical interaction ComPPI
CAPN1 NDUFB7 25348397 N/A physical interaction ComPPI
CAPN1 ACTC1 12358155 14525934 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
CAPN1 BZW2 25348397 N/A physical interaction ComPPI
CAPN1 CNDP2 25348397 N/A physical interaction ComPPI
CAPN1 G6PD 25348397 N/A physical interaction ComPPI
CAPN1 GNS 25348397 N/A physical interaction ComPPI
CAPN1 LDHAL6B 25348397 N/A physical interaction ComPPI
CAPN1 PEPD 25348397 N/A physical interaction ComPPI
CAPN1 PFAS 25348397 N/A physical interaction ComPPI
CAPN1 PPP4R3B 25348397 N/A physical interaction ComPPI
CAPN1 EEF2 25348397 N/A physical interaction ComPPI
CAPN1 GBP2 25348397 N/A physical interaction ComPPI
CAPN1 GINS3 25348397 N/A physical interaction ComPPI
CAPN1 GLA 25348397 N/A physical interaction ComPPI
CAPN1 GLS 25348397 N/A physical interaction ComPPI
CAPN1 TP53 12432277 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CAPN1 NMT1 25348397 N/A physical interaction ComPPI
CAPN1 ATG5 25348397 N/A physical interaction ComPPI
CAPN1 FNTB 25348397 N/A physical interaction ComPPI
CAPN1 CAPNS2 25348397 N/A physical interaction ComPPI
CAPN1 ATP6V1A 25348397 N/A physical interaction ComPPI
CAPN1 GSTO1 25348397 N/A physical interaction ComPPI
CAPN1 MAN2A1 25348397 N/A physical interaction ComPPI
CAPN1 EIF2A 25348397 N/A physical interaction ComPPI
CAPN1 CEP164 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CAPN1 KATNA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAPN1 COG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAPN1 POLA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAPN1 ANKRD17 25348397 N/A physical interaction ComPPI
CAPN1 CARS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAPN1 FBXL12 25348397 N/A physical interaction ComPPI
CAPN1 CD99L2 25348397 N/A physical interaction ComPPI
CAPN1 TRIP12 25348397 N/A physical interaction ComPPI
CAPN1 CD109 25348397 N/A physical interaction ComPPI
CAPN1 CAPN8 25348397 N/A physical interaction ComPPI
CAPN1 NES 25348397 N/A physical interaction ComPPI
CAPN1 EZR 22805611 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CAPN1 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
GNG12 CAPN1 14525934 25348397 27898060 7493986 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
GINS2 CAPN1 25348397 N/A physical interaction ComPPI
CAPN1 BID 12000759 14525934 N/A experimental interaction detection HPRD
TNIP2 CAPN1 24234451 30561431 association virotrap IntAct
PDIA3 CAPN1 24234451 30021884 physical association cross-linking study IntAct
SRC CAPN1 12843408 27898060 N/A N/A OmniPath
CAPN1 SPTAN1 27898060 8993318 N/A N/A OmniPath
CAPN1 BCL2L1 12000759 27898060 inhibition N/A OmniPath
CAPN1 BID 12000759 27898060 stimulant N/A OmniPath
CAPN1 BCL2 12000759 27898060 inhibition N/A OmniPath
CAPN1 GSK3A 25969760 27898060 stimulant N/A OmniPath
CAPN1 TP53 12432277 27898060 N/A N/A OmniPath
CAPN1 MAP2 27898060 8391085 inhibition N/A OmniPath
CAPN1 MAPT 1730702 25969760 27898060 inhibition N/A OmniPath
CAPN1 ATG5 16998475 27898060 inhibition,stimulant N/A OmniPath
CAPN1 GSK3B 25969760 27898060 stimulant N/A OmniPath
CAPN1 OGG1 18294929 27898060 inhibition N/A OmniPath
CAPN1 STAT3 21988832 27898060 N/A N/A OmniPath
CAPN1 CDK5R1 10830966 25969760 27898060 stimulant N/A OmniPath
CAPN1 GRIN2A 10846184 11553682 11677266 27898060 inhibition N/A OmniPath
CAPN1 SPTBN2 11880203 12446661 27898060 inhibition N/A OmniPath
CAPN1 CABIN1 12114545 27898060 inhibition N/A OmniPath
CAPN1 GRIA1 11677266 27898060 inhibition N/A OmniPath
CAPN1 ITGB3 27898060 7592818 inhibition N/A OmniPath
CAST CAPN1 12684003 20679491 25969760 26496610 27898060 inhibition N/A OmniPath
CAPN1 CASP14 12200134 27898060 N/A N/A OmniPath

Visualization