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GENE：CDKN2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDKN2B
FullNmae cyclin dependent kinase inhibitor 2B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1788
EnsembleID ENSG00000147883
Uniprot P42772

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDKN2B mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN2B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN2B apoptosis 34150056 In cells treated with sevoflurane, overexpression of CDKN2B-AS1 could inhibit caspase-3 and caspase-9 activities and the degree of apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
CDKN2B GO:0000079,GO:0000079,GO:0001889,GO:0004861,GO:0004861,GO:0004861,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0007049,GO:0008285,GO:0008285,GO:0014070,GO:0019901,GO:0019901,GO:0030219,GO:0030511,GO:0030858,GO:0031668,GO:0031670,GO:0034097,GO:0042326,GO:0048536,GO:0050680,GO:0060253,GO:0070316,GO:0071560,GO:0090398,GO:2000045,GO:2000134

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDKN2B hsa:1030 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa04110 Cell cycle - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa04218 Cellular senescence - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa04934 Cushing syndrome - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
CDKN2B hsa:1030 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDKN2B ELP1 16169070 23180781 physical association two hybrid InnateDB
SMAD4 CDKN2B 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN2B FOXO3 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
KLF5 CDKN2B 19419955 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
CDKN2B PBX1 21746878 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN2B KLF4 21746878 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR CDKN2B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SP1 CDKN2B 10649433 7592908 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SP3 CDKN2B 10649433 7592908 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 CDKN2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CDKN2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CDKN2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CDKN2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BCL6 CDKN2B 22723377 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 CDKN2B 19545050 trascriptional regulation,stimulation inferred by curator TFlink
EP300 CDKN2B 19419955 22000024 trascriptional regulation,stimulation inferred by curator TFlink
EZH2 CDKN2B 21697275 trascriptional regulation,stimulation inferred by curator TFlink
FOXO3 CDKN2B 19419955 trascriptional regulation,stimulation inferred by curator TFlink
KLF5 CDKN2B 19419955 trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 CDKN2B 19419955 trascriptional regulation,stimulation inferred by curator TFlink
SMAD7 CDKN2B 15555279 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CDKN2B 10649433 7592908 trascriptional regulation,stimulation inferred by curator TFlink
STAT5A CDKN2B 22723377 trascriptional regulation,stimulation inferred by curator TFlink
ZBTB17 CDKN2B 22000024 trascriptional regulation,stimulation inferred by curator TFlink
MYC CDKN2B N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 CDKN2B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001EFEC1 CDKN2B 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000ED600 CDKN2B 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000122ED0 CDKN2B 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000023F008 CDKN2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004A6E26 CDKN2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039D790 CDKN2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 CDKN2B 25416803 28214350 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ARPC3 CDKN2B 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PIAS2 CDKN2B 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
CDK6 CDKN2B 23602568 24234451 25348397 25416956 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid array,tandem affinity purification,bimolecular fluorescence complementation,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CNKSR3 CDKN2B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDIT4L CDKN2B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PICK1 CDKN2B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF1 CDKN2B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ISL1 CDKN2B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MDM2 CDKN2B 17373842 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SPG21 CDKN2B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TGFB1I1 CDKN2B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ZBTB17 CDKN2B 11283613 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RUSC1 CDKN2B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CEP126 CDKN2B 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CDK8 CDKN2B 12007796 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDKN2B MAGEA11 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2B CDK4 14525934 16169070 16189514 19447967 21900206 23455922 23602568 24234451 25348397 25910212 26496610 7478582 9111314 9163429 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,tandem affinity purification,bimolecular fluorescence complementation,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid ComPPI,HPRD,IntAct
CDKN2B ELP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2B CCDC90B 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2B APP 25348397 N/A physical interaction ComPPI
CDKN2B PYCR3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2B NIF3L1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2B CCDC33 25348397 N/A physical interaction ComPPI
CDKN2B CCNC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2B ATP6V1H 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2B INCA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2B CDK17 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RTL8C CDKN2B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF20 CDKN2B 25348397 N/A physical interaction ComPPI
CDKN2B CDK4 16169070 16189514 19447967 21900206 23455922 23602568 26186194 26496610 27898060 7478582 9042862 9111314 9163429 inhibition N/A OmniPath

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