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GENE：IL1RAP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL1RAP
FullNmae interleukin 1 receptor accessory protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5995
EnsembleID ENSG00000196083
Uniprot Q9NPH3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL1RAP apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL1RAP GO:0002114,GO:0004908,GO:0005149,GO:0005576,GO:0005886,GO:0005886,GO:0006954,GO:0006955,GO:0015026,GO:0016020,GO:0032736,GO:0032753,GO:0032754,GO:0032755,GO:0038172,GO:0045087,GO:0050135,GO:0051092,GO:0051965,GO:0061809,GO:0065003,GO:0070498,GO:0098978,GO:0099151,GO:0099545,GO:0099560,GO:1905606

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL1RAP hsa:3556 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
IL1RAP hsa:3556 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL1RAP hsa:3556 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL1RAP hsa:3556 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL1R1 IL1RAP 11274345 12620219 12682231 14660645 15866876 16878026 17704786 17942936 18977329 19104081 19161412 23180781 23202296 23681101 23811849 24727385 26192618 9371760 9430229 association,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IRAK4 IL1RAP 11274345 12620219 12682231 14660645 16878026 17704786 18977329 19161412 23681101 23811849 26192618 interaction type N/A ACSN
MYD88 IL1RAP 11274345 12620219 12682231 13679373 14660645 15849357 16878026 17704786 18977329 19161412 23180781 23681101 23811849 26192618 9374458 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IL1RAP IRAK1 11274345 12620219 12682231 12738796 14660645 15044087 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23180781 23681101 23811849 26192618 9371760 9374458 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TMED7 IL1RAP 12721283 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 IL1RAP 12659850 23180781 physical association gst pull down InnateDB
IL1RAP PIK3CG 15044087 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1RAP IL1R1 12530978 15044087 23180781 23331499 9371760 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
TOLLIP IL1RAP 13679373 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1R2 IL1RAP 20802483 23180781 physical association x-ray crystallography InnateDB
IL1RAP IL1R2 20802483 23180781 physical association surface plasmon resonance InnateDB
IL1RAP IL1B 20802483 23180781 physical association surface plasmon resonance InnateDB
IL1RAP IL1RL1 19836339 23180781 physical association isothermal titration calorimetry,nuclear magnetic resonance InnateDB
IL1RAP IL33 19836339 23180781 physical association isothermal titration calorimetry,nuclear magnetic resonance InnateDB
IL33 IL1RAP 18450470 23180781 physical association dynamic light scattering InnateDB
IL1RAP IL1RAP 10854325 12530978 26467481 bind,up-regulates,down-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR IL1RAP 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IL1RAP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 IL1RAP 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 IL1RAP 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 IL1RAP 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000029D9F1 IL1RAP 21282569 25416803 mrna cleavage,inhibition array technology TarBase
URS00000ED600 IL1RAP 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 IL1RAP 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 IL1RAP 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000100748 IL1RAP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001EFBE3 IL1RAP 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS000050CCE0 IL1RAP 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00001CC4BD IL1RAP 22100165 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD IL1RAP 22100165 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 IL1RAP 22100165 22291592 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IL1RAP IL1R1 25361965 interaction type N/A PTMCode2
IL1R1 IL1RAP 25361965 interaction type N/A PTMCode2
IL1RAP IL1B 25361965 interaction type N/A PTMCode2
IL1B IL1RAP 25361965 interaction type N/A PTMCode2
IL1RAP IL1R2 25361965 interaction type N/A PTMCode2
IL1R2 IL1RAP 25361965 interaction type N/A PTMCode2
IL1RAP SIRPA 25361965 interaction type N/A PTMCode2
SIRPA IL1RAP 25361965 interaction type N/A PTMCode2
IL1RAP IRAK1 25361965 interaction type N/A PTMCode2
IRAK1 IL1RAP 25361965 interaction type N/A PTMCode2
IL1RAP TIRAP 25361965 interaction type N/A PTMCode2
TIRAP IL1RAP 25361965 interaction type N/A PTMCode2
IL1RAP MYD88 25361965 interaction type N/A PTMCode2
MYD88 IL1RAP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 IL1RAP 16306937 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA1 IL1RAP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAC1 IL1RAP 11416133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PIK3R1 IL1RAP 10373529 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD2 IL1RAP 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
IL1RAP IRAK1 14525934 25348397 9371760 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IL1RAP MYD88 11880380 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL1RAP IL18R1 14525934 25348397 27898060 8626725 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
IL1RAP TOLLIP 10854325 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
IL1RAP TICAM2 12721283 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
IL1RAP STAT3 14525934 25348397 27898060 9923604 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
IL1RAP SIRPA 12483539 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL1RAP IL1B 14525934 16306937 20802483 22426547 24234451 25348397 9820540 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
IL1RAP IL1A 14525934 25348397 9820540 N/A experimental interaction detection,in vitro ComPPI,HPRD
IL1RAP IL1R1 14525934 20802483 22426547 24234451 25348397 9371760 physical association experimental interaction detection,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
IL1RAP IL1R2 14525934 20802483 24234451 25348397 9862719 physical association experimental interaction detection,surface plasmon resonance,x-ray crystallography,in vivo ComPPI,HPRD,IntAct
IL1RAP MARCHF8 25348397 N/A physical interaction ComPPI
IL1RAP MC4R 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IL1RAP CCNI 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IL1RAP HAVCR2 25348397 N/A physical interaction ComPPI
IL1RAP PCDHA12 25348397 N/A physical interaction ComPPI
IL1RAP PCDHGB4 25348397 N/A physical interaction ComPPI
IL1RAP TRAF3 16306937 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRPF40A IL1RAP 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PRKCI IL1RAP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MYD88 IL1RAP 11880380 13679373 15849357 27898060 9374458 inhibition N/A OmniPath
IL1B IL1RAP 20802483 27898060 9820540 stimulant N/A OmniPath
IL1RAP IL1B 20802483 27898060 9820540 inhibition N/A OmniPath
IL1R1 IL1RAP 10854325 12530978 15044087 15866876 17507369 24735611 27898060 9371760 9430229 inhibition,stimulant N/A OmniPath
IL1RAP IL1R1 10854325 12530978 15044087 15866876 17507369 24735611 27898060 9371760 9430229 inhibition,stimulant N/A OmniPath
IL1RAP IRAK1 15044087 24735611 27898060 9371760 9374458 N/A N/A OmniPath
IL1RAP TOLLIP 10854325 13679373 27898060 inhibition N/A OmniPath

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