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GENE：PITX2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PITX2
FullNmae paired like homeodomain 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9005
EnsembleID ENSG00000164093
Uniprot Q99697

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PITX2 apoptosis 39169141 The role of Pitx2 in regulating apoptosis was demonstrated in experiments using rat endothelial cell lines, and it was found to be regulated by the Wnt/β-catenin pathway. retulator signature

Go Annotation:

GeneSymbol Go id
PITX2 GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0003253,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0006357,GO:0006357,GO:0007368,GO:0009653,GO:0035315,GO:0035993,GO:0042476,GO:0043010,GO:0045944,GO:0048536,GO:0060126,GO:0060127,GO:0060971,GO:0061072,GO:0061325,GO:0061629,GO:0070986,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PITX2 hsa:5308 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LEF1 PITX2 15728254 23180781 physical association pull down InnateDB
CTNNB1 PITX2 12464179 15728254 21071413 23180781 23331499 stimulation,physical association pull down InnateDB,SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
AR PITX2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 PITX2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PITX2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 PITX2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PITX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PITX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PITX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PITX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PITX2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F2 PITX2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002A71AD PITX2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003FA24D PITX2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 PITX2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB PITX2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 PITX2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD PITX2 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PITX2 ARFRP1 25361965 interaction type N/A PTMCode2
ARFRP1 PITX2 25361965 interaction type N/A PTMCode2
PITX2 CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 PITX2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK PITX2 19174163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPA8 PITX2 25348397 N/A anti tag coimmunoprecipitation ComPPI
HSP90AB1 PITX2 25348397 N/A anti tag coimmunoprecipitation ComPPI
PRKACB PITX2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
FOXC2 PITX2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD3 PITX2 25348397 N/A physical interaction ComPPI
HERC5 PITX2 25348397 N/A physical interaction ComPPI
YBX1 PITX2 19174163 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
RFC2 PITX2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
MYC PITX2 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
HNRNPU PITX2 19174163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ZNHIT3 PITX2 25348397 N/A physical interaction ComPPI
MEF2A PITX2 25348397 N/A two hybrid ComPPI
PDLIM1 PITX2 12464179 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CTNNB1 PITX2 12464179 14525934 15728254 19174163 24234451 25241761 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CDC37 PITX2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
TRIM25 PITX2 25348397 N/A physical interaction ComPPI
PITX2 PROP1 14525934 25348397 27898060 9685346 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PITX2 KAT5 12464179 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PITX2 HDAC1 12464179 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PITX2 LEF1 14525934 15728254 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PITX2 AHCYL2 25348397 N/A physical interaction ComPPI
PITX2 AHCYL1 25348397 N/A physical interaction ComPPI
PITX2 LRRC46 25348397 N/A physical interaction ComPPI
PITX2 IER2 25348397 N/A physical interaction ComPPI
PITX2 RBPJ 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PITX2 FOXC1 25348397 N/A anti tag coimmunoprecipitation ComPPI
PITX2 NCL 19174163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PITX2 GPR158 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
WDR5 PITX2 25348397 N/A physical interaction ComPPI
PITX2 PITX2 11763998 14525934 15466416 24234451 N/A experimental interaction detection,pull down HPRD,IntAct
CTNNB1 PITX2 12464179 15728254 25241761 27898060 stimulant N/A OmniPath
LEF1 PITX2 15728254 19850024 27898060 stimulant N/A OmniPath

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